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Home > Encyclopedia > Manganese gluconate

Manganese gluconate

pharmaceutical raw materials
Manganese gluconate structure

Manganese gluconate 

structure
  • CAS No:

    6485-39-8

  • Formula:

    C12H22MnO14

  • Chemical Name:

    Manganese gluconate

  • Synonyms:

    Manganese,bis(D-gluconato-κO1,κO2)-,(T-4)-;Gluconic acid,manganese salt (2:1);Manganese,bis(D-gluconato-O1,O2)-,(T-4)-;D-Gluconic acid,manganese complex;(T-4)-Bis(D-gluconato-κO1,κO2)manganese;Manganese gluconate;84368-35-4

  • Categories:

    Food Additives  >  Nutrition Supplements

Description

White or pale pink, slightly hygroscopic, crystalline powder.


Manganese gluconate is a manganese salt of gluconic acid with the chemical formula C12H22MnO14 x 2H2O. It is typically obtained by reacting manganese carbonate with gluconic acid in aqueous medium and then crystallizing the product to form a slightly pink powder. Manganese gluconate is a direct ingredient in food substances as a nutrient supplement. In pharmaceutical preparations it is used as a [DB06757] supplement.

Manganese gluconate Basic Attributes

445.23

445.039001

229-350-4

7G09WJ8QIR

2918160000

Characteristics

283

131ºC

375.2ºC

soluable in hot water

Combustible, fire emits spicy manganese-containing spicy stimulating smoke

Safety Information

Warehouse low temperature, ventilated, dry

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Substance added directly to human food affirmed as generally recognized as safe (GRAS).|Manganese gluconate in nutrients and/or dietary supplements is generally recognized as safe when used in accordance with good manufacturing or feeding practices.|Trace minerals added to animal feeds. These substances added to animal feeds as nutritional dietary supplements are generally recognized as safe when added at levels consistent with good feeding practice. Element: Manganese; Source compound: manganese gluconate. (All substances listed may be in anhydrous or hydrated form.)

|Warning|H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]|P264, P280, P305+P351+P338, and P337+P313|Aggregated GHS information provided by 95 companies from 2 notifications to the ECHA C&L Inventory.|Danger|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P260, P264, P270, P280, P301+P312, P305+P351+P338, P310, P314, P330, and P501

SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.

Permissible Exposure Limit: Table Z-1 Ceiling value: 5 mg/cu m. /Manganese cmpd (as Mn)/

Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 1 mg/cu m. /Manganese compounds and fume (as Mn)/|Recommended Exposure Limit: 15 Min Short-Term Exposure Limit: 3 mg/cu m. /Manganese compounds and fume (as Mn)/

Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Manganese gluconate is included on this list.|... Substances for which a Federal Register notice has been published that included consideration of the serious health effects, including cancer, form ambient air exposure to the substance. Manganese (50 FR 32627; Aug. 13, 1985) is included on this list. /Manganese/

Drug Information

Manganese gluconate is currently only available in combination products. It is indicated for the prophylactic or nutritional supplementation of [DB06757].|FDA Label

Manganese gluconate is a salt which dissociates in body fluids to form manganese and gluconic acid. Its pharmacological effects are due to the normal role of [DB06757] in the body.

Acts as a [DB06757] supplement. See [DB06757] for information on its role in the body.

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . /Manganese and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or in severe respiratory distress. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors for hypotension with a normal fluid volume. Watch for signs of fluid overload ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Manganese and related compounds/

boron gluconate

Manganese gluconate Use and Manufacturing

Methods of Manufacturing

Derived from the reaction of gluconic acid and manganese hydroxide.

Uses

Manganese can activate a large number of enzymes, participate in the body~"s metabolic activities, promote human growth and normal osteogenesis, and can cause growth retardation and reproductive function resistance when it is lacking. It is a good food fortifier.

Grades: pharmaceutical; FCC /Food Chemicals Codex/ /Dihydrate/

Cosmetics -> Skin conditioning

Computed Properties

Molecular Weight:445.23
Hydrogen Bond Donor Count:10
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:8
Exact Mass:445.038998
Monoisotopic Mass:445.038998
Topological Polar Surface Area:283
Heavy Atom Count:27
Complexity:165
Defined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes

Material

Drug Function and Efficacy

Manganese gluconate supplies manganese, a cofactor for superoxide dismutase, providing antioxidant protection. It supports skin metabolism and connective tissue formation.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Registered Holders

  • INNER MONGOLIA BAIYI Pharmaceutical Co., Ltd.

    China China
    Active
  • TOMITA PHARMACEUTICAL CO.,LTD.

    United States United States
    Inactive
  • DRAXIMAGE INC

    United States United States
    Inactive

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