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OXYPEUCEDANIN

OXYPEUCEDANIN structure

CAS No:
737-52-0
Formula:
C16H14O5
Chemical Name:
OXYPEUCEDANIN
Synonyms:
OXYPEUCEDANIN;oxypeucadanin;4-(3,3-Dimethylglycidyloxy)-7H-furo[3,2-g][1]benzopyran-7-one;4-(3,3-Dimethyloxiran-2-ylmethoxy)-7H-furo[3,2-g][1]benzopyran-7-one;4-[(3,3-Dimethyloxiranyl)methoxy]-7H-furo[3,2-g][1]benzopyran-7-one;Oxypencedanin;4-[(3,3-dimethyloxiran-2-yl)methoxy]furo[3,2-g]chromen-7-one;Oxypeucedanin, 98%, from Angelica biserrata (Shan & C. Q. Yuan) C. Q. Yuan & Shan
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Oxypeucedanin is a furocoumarin derivative isolated from Angelica dahurica. Oxypeucedanin is a selective open-channel blocker, inhibits the hKv1.5 current with an IC50 value of 76 nM. Oxypeucedanin prolongs cardiac action potential duration (APD), is a potential antiarrhythmic agent for atrial fibrillation[1]. Oxypeucedanin induces cell apoptosis through inhibition of cancer cell migration[2].

Solid

(R)-Oxypeucedanin is a member of psoralens.

White powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Angelica dahurica and Fa Luo Hai.

OXYPEUCEDANIN Basic Attributes

Molecular Weight：

286.28

Exact Mass：

286.084137

Color/Form：

White

HScode：

29329990

Characteristics

PSA：

61.2

XLogP3：

2.6

Appearance：

Solid

Density：

1.320±0.06 g/cm3(Predicted)

Melting Point：

141-142 °C

Boiling Point：

469.5±45.0 °C(Predicted)

Flash Point：

237.8±28.7 °C

Refractive Index：

1.634

Critical Temperature & Pressure：

under inert gas (nitrogen or Argon) at 2-8°C

Safety Information

wgk germany：

WGK 1

Precautionary statement(s)：

P261, P272, P280, P302+P352, P321, P333+P313, P363, P501

Hazard Statements：

H317

GHS Classification：

|Warning|H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]|P261, P272, P280, P302+P352, P321, P333+P313, P363, and P501|Aggregated GHS information provided by 12 companies from 1 notifications to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

4-(2,3-dihydroxy-3-methylbutoxy)-7H-furo(3,2-g)(1)benzopyran-7-one

OXYPEUCEDANIN Use and Manufacturing

Oxypeucedanin is a derivative of Psoralen (P839800) which are phytoalexins; they are used by plants in a defensive response to attacks by fungi and insects. They have also shown photosensitizing and phototoxic effects in animals and humans and have been used in photochemotherapy for management of vitiligo, psoriasis, and mycosis fungoides. Used as photochemical probe in biological systems.

Computed Properties

Molecular Weight:286.28
XLogP3:2.6
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:286.08412354
Monoisotopic Mass:286.08412354
Topological Polar Surface Area:61.2
Heavy Atom Count:21
Complexity:471
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Oxypeucedanin

CAS No.: 737-52-0

Content: 99.00%

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