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Home > Encyclopedia > Ethane, 1-bromo-2-fluoro-

Ethane, 1-bromo-2-fluoro-

Ethane, 1-bromo-2-fluoro- structure

Ethane, 1-bromo-2-fluoro- 

structure
  • CAS No:

    762-49-2

  • Formula:

    C2H4BrF

  • Chemical Name:

    Ethane, 1-bromo-2-fluoro-

  • Synonyms:

    Ethane,1-bromo-2-fluoro-;1-Bromo-2-fluoroethane;1-Fluoro-2-bromoethane;2-Fluoroethyl bromide;2-Bromofluoroethane;NSC 172603

  • Categories:

    Organic Chemistry  >  Organic Fluorine Compound

Description

CLEAR COLOURLESS LIQUID

Ethane, 1-bromo-2-fluoro- Basic Attributes

126.96

126.96

212-100-3

9B15FC1III

172603

DTXSID6073233

Characteristics

0

1.21

pale yellow liquid

1.7044 g/cm3 @ Temp: 25 °C

70-72 °C

71-72 °C @ Press: 760 Torr

-1°C

1.395

soluble in alcohol, ether

Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area.

Safety Information

II

3.1

1992

11-28-36/37/38-59

16-26-33-36/37/39-59-45-36/37-28

KH6610000

Xi,N,T+,F

Irritant

Stable under normal temperatures and pressures.

P210, P233, P240, P241, P242, P243, P261, P262, P264, P270, P271, P280, P301+P310, P302+P350, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P370+P378, P403+P233, P403+P235, P405, P501, P502

H225

Dangerous ... on contact with acid or acid fumes, they emit highly toxic fumes. /Fluorides/

Zakhari S, Aviado DM; Cardiovascular Toxicology of Aerosol Propellants, Refrigerants and Related Solvents; Target Organ Toxicology Series: Cardiovascular Toxicology, XII+ 388 pages; Raven Press: New York, NY 281-326 (1982). Review of the toxicology of aerosol propellants, refrigerants and related solvents on the cardiovascular system of humans.

|Danger|H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P261, P262, P264, P270, P271, P280, P301+P310, P302+P350, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P370+P378, P403+P233, P403+P235, P405, P501, and P502|Aggregated GHS information provided by 45 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Many of the fluorocarbons are good solvents of skin oil, so protective ointment should be used. /Fluorocarbons/|NEOPRENE GLOVES, PROTECTIVE CLOTHING, & EYE PROTECTION MINIMIZE RISK OF TOPICAL CONTACT. DEGREASING EFFECT ON SKIN CAN BE TREATED WITH LANOLIN OINTMENT. /FLUOROCARBONS/|FORCED AIR VENTILATION @ LEVEL OF VAPOR CONCN TOGETHER WITH USE OF INDIVIDUAL BREATHING DEVICES WITH INDEPENDENT AIR SUPPLY WILL MINIMIZE RISK OF INHALATION. LIFELINES SHOULD BE WORN WHEN ENTERING TANKS OR OTHER CONFINED SPACES. /FLUOROCARBONS/

SUFFICIENT EXHAUST & GENERAL VENTILATION SHOULD BE PROVIDED TO KEEP VAPOR CONCN BELOW RECOMMENDED LEVELS. /FLUOROCARBONS/|INHALATION OF FLUOROCARBON VAPORS SHOULD BE AVOIDED. /FLUOROCARBONS/|Forced air ventilation at the level of vapor concentration together with the use of individual breathing devices with independent air supply will minimize the risk of inhalation. Lifelines should be worn when entering tanks or other confined spaces. /Fluorocarbons/|Enclosure of process materials and isolation of reaction vessels and proper design and operation of filling heads for packaging and shipping /are administrative controls that may be instituted to limit occupational exposure to fluorocarbons during manufacture, packaging, and use/. /Fluorocarbons/|For more Preventive Measures (Complete) data for 1-BROMO-2-FLUOROETHANE (7 total), please visit the HSDB record page.

Toxicity

IF INHALATION OCCURS, EPINEPHRINE OR OTHER SYMPATHOMIMETIC AMINES & ADRENERGIC ACTIVATORS SHOULD NOT BE ADMIN SINCE THEY WILL FURTHER SENSITIZE HEART TO DEVELOPMENT OF ARRHYTHMIAS. /FLUOROCARBONS/

In persons with impaired pulmonary function, especially those with obstructive airway diseases, the breathing of Refrigerant 114 might cause exacerbation of symptoms due to its irritant properties. ... In persons with impaired cardiovascular function, especially those with history of cardiac arrhythmias, the inhalation of Refrigerant 114 might cause exacerbation of disorders of the conduction mechanism due to sensitizing effects on the myocardium. /Freon 114/|IT IS POSSIBLE THAT PT WITH CARDIAC OR RESP DISORDERS MAY PROVE ESP SUSCEPTIBLE. /FLUOROCARBONS/

... PHOTODISSOCIATION OF FLUOROCARBONS IN STRATOSPHERE PRODUCES SIGNIFICANT AMT OF CHLORINE ATOMS /SRP: FLUORINE ATOMS AND BROMINE ATOMS/ & LEADS TO DESTRUCTION OF ATMOSPHERIC OZONE. REDUCTION IN OZONE ALLOWS MORE UV LIGHT TO REACH EARTH'S SURFACE ... /FLUOROCARBONS/

... IN THE MANUFACTURE, USE, SERVICING, & DISPOSAL OF REFRIGERATION UNITS, FOOD PROCESSING, SOLVENT APPLICATIONS, PLASTIC FOAM BLOWING, & FIRE EXTINGUISHING. /FLUOROCARBONS/

Drug Information

... MAIN FACTOR AFFECTING FATE OF FLUOROCARBONS IS BODY FAT, WHERE THEY ARE CONCENTRATED & SLOWLY RELEASED INTO BLOOD @ CONCN THAT SHOULD NOT CAUSE ANY RISK OF CARDIAC SENSITIZATION. /FLUOROCARBONS/|THERE IS A SIGNIFICANT ACCUMULATION OF FLUOROCARBONS IN BRAIN, LIVER & LUNG COMPARED TO BLOOD LEVELS, SIGNIFYING A TISSUE DISTRIBUTION OF FLUOROCARBONS SIMILAR TO THAT OF CHLOROFORM. /FLUOROCARBONS/|Abosrption of fluorocarbons is much lower after oral ingestion (35-48 times) than after inhalation. ... The lung generally has the highest fluorocarbon concentrations on autopsy. /Fluorocarbons/|Although fluorocarbons cause cardiac sensitization in certain animal species, rapid elimination prevents the development of cardiotoxic concentrations from aerosol bronchodilator use except at exceedingly high doses (12 to 24 doses in 2 minutes). /Fluorocarbons/|FLUOROCARBON COMPOUNDS ARE LIPID-SOLUBLE AND THUS ARE GENERALLY WELL ABSORBED THROUGH LUNG. ABSORPTION AFTER INGESTION IS 35 TO 48 TIMES LOWER THAN AFTER INHALATION. ... FLUOROCARBONS ARE ELIMINATED BY WAY OF LUNG. /FLUOROCARBON COMPOUNDS/

If the diagnosis of solvent abuse is suspected it can be confirmed by biochemical examination of the blood or urine. Emergency treatment is supportive and includes decontamination, oxygen, and any specific therapy required in a particular case such as antiarrhythmics or anticonvulsants. A few patients may require intermittent positive-pressure ventilation, dialysis, or treatment for hepatic failure. /Solvent abuse/|... In persons who are intoxicated with fluorocarbons, steps can be taken to lessen the risk of arrhythmias. ... Before evaluation at the hospital, patients should be advised to avoid strenuous exercise. In the hospital, patients can be placed in a quiet, nonthreatening environment and sedated if necessary. If hypoxic, oxygen should be administered and metabolic abnormalities corrected. Sympathomimetic drugs should be avoided. Ventricular arrhythmias are best treated with beta-blocking agents. /Fluorocarbons/|Patients with fluorohydrocarbon poisoning should not be given epinephrine (Adrenalin) or similar drugs because of the tendency of fluorohydrocarbon to induce cardiac arrhythmia, including ventricular fibrillation. /Fluorohydrocarbons/|Victims of Freon inhalation require management for hypoxic, CNS anesthetic, and cardiac symptoms. Patients must be removed from the exposure environment, and high-flow supplemental oxygen should be utilized. The respiratory system should be evaluated for injury, aspiration, or pulmonary edema and treated appropriately. CNS findings should be treated supportively. A calm environment with no physical exertion is imperative to avoid increasing endogenous adrenegic levels. Exogenous adrenergic drugs must not be used to avoid inducing sensitized myocardial dysrhythmias. Atropine is ineffective in treating bradyarrhythmias. For ventricular dysrhythmias, diphenylhydantoin and countershock may be effective. Cryogenic dermal injuries should be treated by water bath rewarming at 40 to 42 °C until vasodilatory flush has returned. Elevation of the limb and standard frostbite management with late surgical debridement should be utilized. Ocular exposure requires irrigation and slit-lamp evaluation for injury. /Freons/|... IF INHALATION OCCURS, EPINEPHRINE OR OTHER SYMPATHOMIMETIC AMINES & ADRENERGIC ACTIVATORS SHOULD NOT BE ADMIN SINCE THEY WILL FURTHER SENSITIZE HEART TO DEVELOPMENT OF ARRHYTHMIAS. /FLUOROCARBONS/

EXCESSIVE SKIN CONTACT WITH LIQ FLUOROCARBONS SHOULD BE MINIMIZED TO PREVENT DEFATTING OF SKIN ... /FLUOROCARBONS/|... THE COMBINATION OF FLUOROCARBON WITH A SYMPATHOMIMETIC BRONCHODILATOR IS POTENTIALLY DANGEROUS FOR THE TREATMENT OF BRONCHIAL ASTHMA. FOR THE SAME REASON, SYMPATHOMIMETIC DRUGS ARE CONTRAINDICATED IN CARDIAC RESUSCITATION OF PATIENTS SUFFERING FROM FLUOROCARBON POISONING. /FLUOROCARBON POISONING/|FLUOROCARBON VAPORS ARE 4 TO 5 TIMES HEAVIER THAN AIR. THUS HIGH CONCN TEND TO ACCUMULATE IN LOW-LYING AREAS, RESULTING IN HAZARD OF INHALATION OF CONCENTRATED VAPORS, WHICH MAY BE FATAL. /FLUOROCARBONS/|UNDER CERTAIN CONDITIONS, FLUOROCARBON VAPORS MAY DECOMPOSE ON CONTACT WITH FLAMES OR HOT SURFACES, CREATING POTENTIAL HAZARD OF INHALATION OF TOXIC DECOMPOSITION PRODUCTS. /FLUOROCARBONS/|For more Human Toxicity Excerpts (Complete) data for 1-BROMO-2-FLUOROETHANE (8 total), please visit the HSDB record page.

1-bromo-2-fluoroethane

Ethane, 1-bromo-2-fluoro- Use and Manufacturing

Methods of Manufacturing

Reaction /of 2-fluoroethanol/ with phosphorus tribromide gives 1-bromo-2-fluoroethane.

Uses

Used as pharmaceutical intermediates for the synthesis of fleroxacin and other drugs

THE BROMINE-CONTAINING FLUOROCARBONS OPERATE BY CHEMICAL INTERRUPTION OF THE COMBUSTION CHAIN, AND ARE USED IN TOTAL FLOODING SYSTEMS FOR COMPUTER ROOMS AND TELEPHONE FACILITIES, AS WELL AS AIRCRAFT AND PORTABLE FIRE EXTINGUISHERS, INCLUDING USE ON THE AIR FORCE P-13 RAPID INTERVENTION CRASH TRUCKS. HALON EMERGES FROM THE FIRE EXTINGUISHER NOZZLE AS A MIXTURE OF 85 PERCENT LIQUID AND 15 PERCENT VAPOR AND IS DISCHARGED OVER LONG DISTANCES. IT COMPLETELY VAPORIZES UPON CONTACT WITH FIRE. /BROMINATED FLUOROCARBONS/

GAS CHROMATOGRAPHIC METHOD FOR DETERMINING FLUOROCARBONS IN AIR IS DESCRIBED. CONCN IN AIR ARE DETERMINED DIRECTLY. /FLUOROCARBONS/|A GAS CHROMATOGRAPHIC PROCEDURE FOR DETERMINING ATMOSPHERIC LEVELS OF FLUOROCARBONS IS DESCRIBED. COLUMN IS TEMP PROGRAMMED TO SEPARATE HALOGENATED COMPONENTS WHILE MAINTAINING SHORT RETENTION TIMES FOR EACH COMPONENT. FREON 113 INCL. /FLUOROCARBONS/|GAS CHROMATOGRAPHIC METHOD FOR MEASURING HALOCARBONS IN AMBIENT AIR SAMPLES IS PRESENTED. /HALOCARBONS/|FLUOROCARBONS IN AIR OF WORKING AREA & IN EXHALED AIR CAN BE ANALYZED BY IR SPECTROMETRY. /FLUOROCARBONS/|GAS CHROMATOGRAPHIC METHOD IS PRESENTED FOR FREONS. /FREONS/

GAS CHROMATOGRAPHIC METHOD FOR DETERMINING FLUOROCARBONS IS DESCRIBED. CONCN IN BODY FLUIDS ARE DETERMINED BY MEANS OF HEAD SPACE ANALYSIS. /FLUOROCARBONS/|FLUOROCARBON DETERMINATION IN BLOOD: GAS CHROMATOGRAPHY WITH ELECTRON CAPTURE DETECTION. /FLUOROCARBONS/

Computed Properties

Molecular Weight:126.96
XLogP3:1.3
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:125.94804
Monoisotopic Mass:125.94804
Heavy Atom Count:4
Complexity:10
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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