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Retinol palmitate

Retinol palmitate structure

CAS No:
79-81-2
Formula:
C36H60O2
Chemical Name:
Retinol palmitate
Synonyms:
Retinol,hexadecanoate;Retinol,palmitate,all-trans-;Retinol palmitate;Arovit;Dispatabs Tabs;Myvak;Myvax;Testavol S;Retinyl palmitate;all-trans-Vitamin A palmitate;Vitamin A palmitate;Axerophthol palmitate;Aquasol A;Aquapalm;all-trans-Retinol palmitate;all-trans-Retinyl palmitate;trans-Retinyl palmitate;trans-Retinol palmitate;Palmitic acid,ester with retinol;Vitazyme A;Arovit (Roche);Lutavit A 500 Plus;Optovit A;VAP 250CK-CWD;VAP 250MS-CWD;250S/N;250S/N-B;Riken A Palmitate 1000E;Retiblan;108066-99-5;7488-89-3;37340-08-2;674786-07-3
Categories:
Cosmetic Ingredient > Skin Conditioning

Description

Retinyl palmitate is an ester of Retinol and is the major form of vitamin A found in the epidermis. Retinyl palmitate has been widely used in pharmaceutical and cosmetic formulations.

Solid

All-trans-retinyl palmitate is an all-trans-retinyl ester obtained by formal condensation of the carboxy group of palmitic (hexadecanoic acid) with the hydroxy group of all-trans-retinol. It is used in cosmetic products to treat various skin disorders such as acne, skin aging, wrinkles, dark spots, and also protect against psoriasis. It has a role as an Escherichia coli metabolite, a human xenobiotic metabolite and an antioxidant. It is a retinyl palmitate and an all-trans-retinyl ester. It derives from an all-trans-retinol.|Retinyl Palmitate is a naturally-occurring phenyl analogue of retinol (vitamin A) with potential antineoplastic and chemopreventive activities. As the most common form of vitamin A taken for dietary supplementation, retinyl palmitate binds to and activates retinoid receptors, thereby inducing cell differentiation and decreasing cell proliferation. This agent also inhibits carcinogen-induced neoplastic transformation, induces apoptosis in some cancer cell types, and exhibits immunomodulatory properties. (NCI04)

Retinol palmitate Basic Attributes

Molecular Weight：

524.86

Exact Mass：

524.86

EC Number：

201-228-5

UNII：

1D1K0N0VVC

NSC Number：

758478

DSSTox ID：

DTXSID1021241

NCI Thesaurus Code：

C1217

HScode：

2936210000

Characteristics

PSA：

26.3

XLogP3：

13.6

Appearance：

oil

Density：

0.9±0.1 g/cm3

Melting Point：

28-29 °C

Boiling Point：

607.5°C at 760 mmHg

Flash Point：

194℃

Refractive Index：

1.508

Water Solubility：

Soluble in chloroform, ether, and vegetable oils. Insoluble in water.

Storage Conditions：

2-8°C

Toxicity：

LD50 (10 day) in mice, rats (mg/kg): 6060, 7910 orally (Kamm)

Safety Information

Transport codes：

UN1170 - class 3 - PG 2 - Ethanol, solution

wgk germany：

hazard class code：

63-53-61-11

safety instructions：

53-23-36/37/39-45-36/37-16-60

RTECS Number：

VH6860000

Marks：

T,Xn,F

Precautionary statement(s)：

P210-P280-P305 + P351 + P338-P337 + P313-P403 + P235

Hazard Statements：

H225-H319

GHS Classification：

|Danger|H315 (24.82%): Causes skin irritation [Warning Skin corrosion/irritation]|P201, P202, P264, P273, P280, P281, P302+P352, P308+P313, P321, P332+P313, P362, P405, and P501|Aggregated GHS information provided by 597 companies from 27 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved. (See all compounds classified as Anticarcinogenic Agents.)|Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. (See all compounds classified as Antioxidants.)

MeSH Entry Terms：

Chocola A

Retinol palmitate Use and Manufacturing

Uses

all-trans-Retinyl Palmitate is an ester derivative of Retinol (R252000). all-trans-Retinyl Palmitate is used as a vitamin supplement in the treatment of Vitamin A deficiency. all-trans-Retinyl Palmitate is used as an antioxidant and a source of vitamin A added to low fat milk and other dairy products.all-trans-Retinyl Palmitate is also a constituent of some topically applied skin care products

Manufacturing Info：

Retinol, hexadecanoate: ACTIVE

Use Classification：

Human drugs -> Rare disease (orphan)|Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Lipids -> Prenol Lipids [PR] -> Isoprenoids [PR01] -> Retinoids [PR0109]|Cosmetics -> Skin conditioning

Computed Properties

Molecular Weight:524.9
XLogP3:13.6
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:21
Exact Mass:524.45933115
Monoisotopic Mass:524.45933115
Topological Polar Surface Area:26.3
Heavy Atom Count:38
Complexity:803
Defined Bond Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It is an essential component for promoting growth, maintaining the visual function of the retina, and maintaining the stability of normal cell membranes. If it is deficient, the body will stop growing, night blindness, dry eyes, and corneal softening will occur.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Compound Vitamin (4) Injection
Ingredients	2ml: Contains: Vitamin A palmitate 2500IU, Vitamin D2200IU, Vitamin E15mg, Vitamin K12mg.
Indication	This product contains vitamin K1 and should not be used in combination with coumarin anticoagulants.
Specifications	2ml
Manufacturer	Xi'an Fenghua Pharmaceutical Co., Ltd.

Vitamin A Palmitate
Specifications	API
Manufacturer	Shanxi PUDE Pharmaceutical Co., Ltd.

Fat-soluble vitamins for injection (I)
Ingredients	This product is a soluble vitamin compound preparation. Each bottle contains 2,300 units of the main drug vitamin A palmitate (equivalent to vitamin A), 10 μg of vitamin D2, 6.4 mg of vitamin E, and 10.2 mg of vitamin K. The excipients of this product are Tween 80, mannitol and water for injection.
Indication	This product contains vitamin K1, which may interact with anticoagulants such as coumarins and heparin and should not be used together.
Specifications	Compound preparations
Manufacturer	Ma'anshan Fengyuan Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

dsm-firmenich Switzerland AG

Switzerland
Active
Haisco Pharmaceutical(Meishan) Co., Ltd.

China
Active
Jiuquan Dadeli Pharmaceutical Co., Ltd.

China
Active

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Guide of Retinol palmitate

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
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Retinol palmitate

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