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Metocurine

Metocurine structure

CAS No:
5152-30-7
Formula:
C40H48N2O6
Chemical Name:
Metocurine
Synonyms:
13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido[3′,2′:14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium,2,3,13a,14,15,16,25,25a-octahydro-9,18,19,29-tetramethoxy-1,1,14,14-tetramethyl-,(13aR,25aS)-;Chondrocurarine,O,O′-dimethyl-;Tubocuraranium,6,6′,7′,12′-tetramethoxy-2,2,2′,2′-tetramethyl-;(13aR,25aS)-2,3,13a,14,15,16,25,25a-Octahydro-9,18,19,29-tetramethoxy-1,1,14,14-tetramethyl-13H-4,6:21,24-dietheno-8,12-metheno-1H-pyrido[3′,2′:14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium;Dimethylchondrocurarine;Metocurine;O,O-Dimethylchondrocurarine;13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido[3′,2′:14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium,2,3,13a,14,15,16,25,25a-octahydro-9,18,19,29-tetramethoxy-1,1,14,14-tetramethyl-,[13aR-(13aR*,25aS*)]-;1397-58-6;17573-08-9;23192-76-9;29605-20-7;34168-57-5
Categories:
Organic Chemistry > Amides

Description

Solid

Metocurine is a member of isoquinolines.|Dimethyltubocurarinium (INN) or metocurine (USAN), also known as dimethyltubocurarine, is a non-depolarizing muscle relaxant. Patients on chronic anticonvulsant drugs are relatively resistant to metocurine.

Metocurine Basic Attributes

Molecular Weight：

652.832

Exact Mass：

652.351

UNII：

V0M92G2U26

Characteristics

PSA：

55.4

XLogP3：

6.7

Appearance：

Solid

Density：

1.1209 (rough estimate)

Water Solubility：

6.42e-06 g/L

Drug Information

Drug Indication：

Metocurine is a muscle relaxant.

MeSH：

Drugs that interrupt transmission at the skeletal neuromuscular junction without causing depolarization of the motor end plate. They prevent acetylcholine from triggering muscle contraction and are used as muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvants. (See all compounds classified as Neuromuscular Nondepolarizing Agents.)

Mechanism of Action：

Metocurine antagonizes the neurotransmitter action of acetylcholine by binding competitively with cholinergic receptor sites on the motor end-plate. This antagonism is inhibited, and neuromuscular block reversed, by acetylcholinesterase inhibitors such as neostigmine, edrophonium, and pyridostigmine.

MeSH Entry Terms：

dimethyl dl-curine dimethochloride

Computed Properties

Molecular Weight:652.8
XLogP3:6.7
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:652.35123726
Monoisotopic Mass:652.35123726
Topological Polar Surface Area:55.4
Heavy Atom Count:48
Formal Charge:2
Complexity:1060
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes