Escin
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Escin
structure -
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CAS No:
6805-41-0
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Chemical Name:
Escin
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Synonyms:
Escin;Escigenin,3-(4-O-β-D-glucopyranosyl-2-O-β-D-xylopyranosyl-β-D-glucopyranuronoside),3-hydroxy-2-methylbutyrate,acetate;Oleanane,escin deriv.;3,5-Epoxypicene,escin deriv.;Aescin;Ba 2672;β-Escinic acid;Aescusan;Aescine;Escusan;Eskuzan;Venocin;Flebostasin Retard;37-02-5;1394-90-7;25255-37-2;47918-34-3;55125-87-6
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CAS No:
Description
Escin, a natural mixture of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent[1].
Pentacyclic triterpene saponins, biosynthesized from protoaescigenin and barringtogenol, occurring in the seeds of AESCULUS. It inhibits edema formation and decreases vascular fragility.
Characteristics
776.08000
-2.64220
white powder
1.46 g/cm3
200-210 °C (decomp) @ Solvent: Ethanol
1140.6ºC at 760 mmHg
311.8ºC
1.627
soluble in methanol.
Safety Information
UN 3077 9 / PGIII
2
R22
S22; S24/25
KF6296000
Xn
P301 + P312 + P330
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P273, P280, P301+P312, P304+P312, P304+P340, P305+P351+P338, P312, P330, P337+P313, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 126 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume. (See all compounds classified as Cardiovascular Agents.)
Aescin
Computed Properties
Molecular Weight:1131.3
XLogP3:0.7
Hydrogen Bond Donor Count:13
Hydrogen Bond Acceptor Count:24
Rotatable Bond Count:16
Exact Mass:1130.55090361
Monoisotopic Mass:1130.55090361
Topological Polar Surface Area:388
Heavy Atom Count:79
Complexity:2300
Undefined Atom Stereocenter Count:27
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
The site of action is the blood vessel wall, which reduces the flow of extravasated body fluid into the surrounding tissues, inhibits exudation, promotes reabsorption of edema, changes capillary permeability, enhances capillary resistance, inhibits the inflammatory process and improves microcirculation.
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Learn More Other Chemicals
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Escin Ia
123748-68-5
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Escin Ib
26339-90-2
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ESCIN IIB
158800-83-0
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escin IIa Formula
158732-55-9
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Horse chestnut, Aesculushippocastanum, ext. Formula
8053-39-2
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Birch, Betulaalba, ext. Formula
84012-15-7
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Hazel, Corylusavellana, ext. Structure
84012-21-5
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Papaya, ext. Structure
84012-30-6
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84012-40-8
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84082-34-8