Teprenone
-
Teprenone
structure -
-
CAS No:
6809-52-5
-
Formula:
C23H38O
-
Chemical Name:
Teprenone
-
Synonyms:
5,9,13,17-Nonadecatetraen-2-one,6,10,14,18-tetramethyl-;6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetraen-2-one;Teprenone;Selbex;Geranylgeranylacetone;E 36U31;E 0671;GGA
- Categories:
-
CAS No:
Characteristics
17.1
7.89140
clear
0.9081 g/cm3 @ Temp: 20.5 °C
155-160 °C @ Press: 0.01 Torr
168.0±9.8 °C
nD20 1.4947
DMSO: >5mg/mL
-20°C
Safety Information
NONH for all modes of transport
3
R36/37/38:Irritating to eyes, respiratory system and skin .
S26-S36/37/39
RA5391300
Xi
Teprenone Use and Manufacturing
A mixture of 3-rac-ketoester 11, (0.07 g, 0.174 mmol) MeOH (0.3 mL), and 5N aqueous KOH (0.15 mL) was heated at 80-85° C. for 2 h, reaction was followed by TLC. In a flask add 100mL Geranyl linalool (0.3 mol) , 68 gram of acetyl Meldrum's acid (0.36mol )and 6.2 g of aluminum isopropoxide (0. 03mol) dissolved in 600mL of p-Xylene. To theflask was immersed in a preheated oil bath to 150 ° C and stirred for 8 hours.The reaction mixture was cooled to room temperature concentrate on a rotary evaporator, Washed with 50 mL of 5percent bymass percentage concentration of NaHCO
An anti-ulcerative. Geranylgeranylacetone can induce expression of HSP70, HSPB8, and HSPB1. Induction of HSP70 expression is protective against the development of various diseases, such as inflammatory bowel disease, hypoxic/ischemic brain injury and spinal and bulbar muscular atrophy (cytoprotective and anti-inflammatory effects). Reports indicate that GGA protects against NSAID-induced gastric and intestinal lesions by induction of HSP70 expression. Other studies have shown that GGA induces expression of HSPB8 and HSPB1 and reduces the formation of amyloid oligomers as well as insoluble aggregates in HSPB5 R120G TG mice.
Computed Properties
Molecular Weight:330.5
XLogP3:7.4
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:12
Exact Mass:330.292265831
Monoisotopic Mass:330.292265831
Topological Polar Surface Area:17.1
Heavy Atom Count:24
Complexity:482
Defined Bond Stereocenter Count:3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Extract from the above information
Registered Holders
-
Rionlon(Tianjin) Pharmaceutical Co., Ltd.
Active
China
-
Sichuan Gowell Pharmaceutical Co., Ltd.
Active
China
-
EIsai China Inc.
Active
China
Recommended Suppliers of Teprenone
-
![China]()
CN
2 YRS
Business licensedTrader Supplier of api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals,CATALYST AND AUXILIARY,FLAVORS AND FRAGRANCES,Chemical Pesticides,ADDITIVE -
![China]()
CN
1 YR
Business licensedTrader Supplier of pregabalin,Tirzepatide,Retatrutide,Food Additives,semaglutide,Cosmetics material,Food additive,Chemical intermediate,Active pharmaceutical ingredientsInquiryUnit Price: $1 /KG FOBCAS No.: 6809-52-5Grade: USP / EP / BP / JP GradeContent: 99.9%
Learn More Other Chemicals
-
Elastins, cartilage, hydrolyzates
100085-10-7
-
Peptones
73049-73-7
-
Micro-Green
10024-66-5
-
Strontium dichloride hexahydrate Formula
10025-70-4
-
2,5-Pyridinedicarboxylic acid Formula
100-26-5
-
N-Acetyl-α-D-glucosamine Formula
10036-64-3
-
Ceramides Structure
100403-19-8
-
1-Methylnicotinamide chloride Structure
1005-24-9
-
What is Noreugenin
1013-69-0
-
What is D-Glucopyranose, 2-(acetylamino)-2-deoxy-, 6-(dihydrogen phosphate), disodium salt
102029-88-9