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Levonorgestrel

Levonorgestrel structure

CAS No:
797-63-7
Formula:
C21H28O2
Chemical Name:
Levonorgestrel
Synonyms:
18,19-Dinorpregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-,(17α)-;18,19-Dinor-17α-pregn-4-en-20-yn-3-one,13-ethyl-17-hydroxy-;(17α)-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one;13-Ethyl-17α-ethynylgon-4-en-17β-ol-3-one;13β-Ethyl-17α-ethynyl-17β-hydroxygon-4-en-3-one;19-Nortestosterone,17-ethynyl-18-methyl-;17β-Hydroxy-18-methyl-19-nor-17α-pregn-4-en-20-yn-3-one;18-Methyl-17α-ethynyl-19-nortestosterone;17α-Ethynyl-17-hydroxy-18-methylestr-4-en-3-one;17α-Ethynyl-18-methyl-19-nortestosterone;13-Ethyl-17α-ethynyl-17-hydroxygon-4-en-3-one;13-Ethyl-17-hydroxy-18,19-dinor-17α-pregn-4-en-20-yn-3-one;17α-Ethynyl-18-homo-19-nortestosterone;13-Ethyl-17-ethynyl-17β-hydroxy-4-gonen-3-one;17α-Ethynyl-13β-ethyl-3-oxo-4-estren-17β-ol;Levonorgestrel;17α-Ethynyl-13-ethyl-19-nortestosterone;Norplant;Follistrel;D-(-)-Norgestrel;Norplant 2;18-Methylnorethindrone;Microluton;(-)-Norgestrel;D-Norgestrel;Norplant II;Levonova;Jadelle;Norlevo;Mirena;Norgestrelem;Wy 5104;Microlut;Norgeston;Dexnorgestrel;Microval;Postinor 2;Lng-IUS;d-(17α)-17-Hydroxy-13-ethyl-18,19-dinorpregn-4-en-20-yn-3-one;Femilis;Femilis Slim;Sino-implant (II);Plan B One-Step;Skyla;Jaydess;121714-72-5;797-62-6;4222-79-1;1050679-25-8
Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System

Description

Levonorgestrel is a synthetic progestogen used as an active ingredient in some hormonal contraceptives.Target: Progesterone ReceptorA synthetic progestational hormone with actions similar to those of progesterone and about twice as potent as its racemic or (+-)-isomer (norgestrel). It is used for contraception, control of menstrual disorders, and treatment of endometriosis. It is usually supplied in a racemic mixture (Norgestrel, 6533-00-2). Only the levonorgestrel isomer is active. Levo

Levonorgestrel Basic Attributes

Molecular Weight：

312.45

Exact Mass：

312.45

EC Number：

212-349-8

HScode：

2937290090

Characteristics

PSA：

37.3

XLogP3：

3.8

Appearance：

Solid

Density：

1.1±0.1 g/cm3

Melting Point：

235-237 °C

Boiling Point：

459.1±45.0 °C at 760 mmHg

Flash Point：

195.4±21.3 °C

Refractive Index：

1.571

Water Solubility：

10mg/L(temperature not stated)

Storage Conditions：

2-8°C

Vapor Pressure：

1.0X10-9 mm Hg at 25 deg C (est)

Specific rotation：

D20 -32.4° (c = 0.496 in CHCl3)

Odor：

Odorless

PKA：

17.91,-1.5

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

20/21/22-40-60

safety instructions：

22-36

RTECS Number：

JF8225000

Marks：

Xn,T

Precautionary statement(s)：

P201-P261-P280-P308 + P313

Hazard Statements：

H312 + H332-H351-H360

Levonorgestrel Use and Manufacturing

progestin

Computed Properties

Molecular Weight:312.4
XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:312.208930132
Monoisotopic Mass:312.208930132
Topological Polar Surface Area:37.3
Heavy Atom Count:23
Complexity:609
Defined Atom Stereocenter Count:6
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Tetrahydrofuran

Drug Function and Efficacy

Significantly inhibit ovulation and prevent fertilized eggs from implanting, and increase the consistency of cervical mucus and the resistance of sperm penetration, thus playing a quick-acting contraceptive role

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Levonorgestrel tablets
Ingredients	Each tablet of this product contains 0.75 mg of the main ingredient levonorgestrel. The auxiliary materials are starch, lactose, sucrose, dextrin, magnesium stearate, and sodium carboxymethyl starch.
Indication	If used with other drugs (especially phenobarbital, phenytoin sodium, rifampicin, carbamazepine, macrolide antibiotics, imidazole antifungal drugs, cimetidine and antiviral drugs, etc.), drug interactions may occur. Please consult your doctor or pharmacist for details.
Specifications	0.75 mg

Levonorgestrel
Manufacturer	Jiangsu Lianhuan Pharmaceutical Co., Ltd.

Levonorgestrel tablets
Ingredients	Each tablet of this product contains 1.5 mg of the main ingredient levonorgestrel. The auxiliary ingredients are lactose, starch, sucrose, sodium carboxymethyl starch, talc, and magnesium stearate.
Indication	If used with other drugs (especially phenobarbital, phenytoin sodium, rifampicin, carbamazepine, macrolide antibiotics, imidazole antifungal drugs, cimetidine and antiviral drugs, etc.), drug interactions may occur. Please consult your doctor or pharmacist for details.
Specifications	1.5mg
Manufacturer	NORTHEAST Pharmaceutical Group Shenyang NO.1 Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

Bayer Ag

Finland
Active
Exeltis(Shanghai) International Pharmaceutical Co., Ltd.

China
Active
Hunan Kyf Pharmaceutical. Co., Ltd.

China
Active

See More Registered Holders

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