[(Chloromethyl)sulfonyl]benzene

General procedure: 0.25 g (2 mmol) of thioanisole as a substrate, 10 mL of acetonitrile and 2 mL of water were placed in a 50 mL three-necked flask.The internal temperature of the flask was 23 ° C.0.79 g (4.8 mmol) of sodium hypochlorite pentahydrate crystals was added thereto at a time and stirred.The internal temperature of the flask rose to 28 ° C. and gradually decreased.GC analysis was carried out 3 hours after the start of the reaction, and 22percent of methyl phenyl sulfoxide, 65percent of methyl phenyl sulfone was formed.As a by-product, 6percent of chloromethyl phenyl sulfoxide, 7percent of chloromethyl phenyl sulfone, A total of 0.8percent of higher order chlorides were observed.0.79 g (4.8 mmol) of sodium hypochlorite pentahydrate crystals was added and stirring was continued for 1 hour.Thioanisole, Methyl phenyl sulfoxide was completely disappeared and 87percent of methyl phenyl sulfone was formed.As impurities, 11percent chloromethyl phenyl sulfone, 0.5percent dichloromethyl phenyl sulfone, Production of trichloromethyl phenyl sulfone 1.3percent was observed.General procedure: 0.25 g (2 mmol) of thioanisole as a substrate, 10 mL of acetonitrile and 2 mL of water were placed in a 50 mL three-necked flask.The internal temperature of the flask was 23 ° C.0.79 g (4.8 mmol) of sodium hypochlorite pentahydrate crystals was added thereto at a time and stirred.The internal temperature of the flask rose to 28 ° C. and gradually decreased.GC analysis was carried out 3 hours after the start of the reaction, and 22percent of methyl phenyl sulfoxide, 65percent of methyl phenyl sulfone was formed.As a by-product, 6percent of chloromethyl phenyl sulfoxide, 7percent of chloromethyl phenyl sulfone, A total of 0.8percent of higher order chlorides were observed.0.79 g (4.8 mmol) of sodium hypochlorite pentahydrate crystals was added and stirring was continued for 1 hour.Thioanisole, Methyl phenyl sulfoxide was completely disappeared and 87percent of methyl phenyl sulfone was formed.As impurities, 11percent chloromethyl phenyl sulfone, 0.5percent dichloromethyl phenyl sulfone, Production of trichloromethyl phenyl sulfone 1.3percent was observed.

Molecular Weight:190.65
XLogP3:1.2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:189.9855283
Monoisotopic Mass:189.9855283
Topological Polar Surface Area:42.5
Heavy Atom Count:11
Complexity:199
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes