2-Pyrrolidinone, 1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-, hydrochloride, hydrate (1:1:1)
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2-Pyrrolidinone, 1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-, hydrochloride, hydrate (1:1:1)
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CAS No:
7081-53-0
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Formula:
C24H30N2O2.ClH.H2O
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Chemical Name:
2-Pyrrolidinone, 1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-, hydrochloride, hydrate (1:1:1)
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Synonyms:
2-Pyrrolidinone,1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-,hydrochloride,hydrate (1:1:1);2-Pyrrolidinone,1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-,monohydrochloride,monohydrate;2-Pyrrolidinone,1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-,monohydrochloride,monohydrate;AHR 619;Doxapram hydrochloride hydrate;1-Ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone hydrochloride hydrate;Doxapram hydrochloride monohydrate;1-Ethyl-4-[2-(morpholin-4-yl)ethyl]-3,3-diphenylpyrrolidin-2-one hydrate hydrochloride
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CAS No:
Description
Doxapram hydrochloride hydrate inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively.Target: Potassium ChannelDoxapram is a respiratory stimulant. Doxapram (15-150 microM) also evoked 3H overflow in a concentration dependent manner, and doxapram-evoked release was inhibited by the Ca2+ channel blocker nifedipine (5 microM). Analysis of released tritiated compounds suggested that doxapram preferentially stimulated the release
2-Pyrrolidinone, 1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-, hydrochloride, hydrate (1:1:1) Basic Attributes
432.99
432.217957
615-173-3
2934990002
Characteristics
33.8
3.78680
217-219 °C
soluble in water, in alcohol and in methylene chloride.
LD50 orally in rats: 261 mg/kg (Goldenthal)
Safety Information
Ⅲ
UN 2811 6.1 / PGIII
6.1
STABLE IN LIGHT & IN AIR /HYDROCHLORIDE/
Missing Phrase - N15.00950417
H301
|Warning|H302 (98.15%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 54 companies from 2 notifications to the ECHA C&L Inventory.
2-Pyrrolidinone, 1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-, hydrochloride, hydrate (1:1:1) Use and Manufacturing
antibacterial
Computed Properties
Molecular Weight:433.0
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:432.2179706
Monoisotopic Mass:432.2179706
Topological Polar Surface Area:33.8
Heavy Atom Count:30
Complexity:487
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes
Drug Function and Efficacy
This product is a respiratory stimulant. In small doses, it reflexively excites the respiratory center through the carotid body chemoreceptors. In large doses, it directly excites the medullary respiratory center, increasing the tidal volume and increasing the respiratory rate to a limited extent. Large doses excite the spinal cord and brainstem, but seem to have no effect on the cerebral cortex. When patients with obstructive pulmonary disease have acute ventilation insufficiency, the use of this drug can improve tidal volume, blood carbon dioxide partial pressure, and oxygen saturation.
Registered Holders
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MIDAS Pharma GmbH
Active
Germany
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Zhejiang Horvar Pharmaceutical Co., Ltd.
Active
China
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Xi'an Li Bang Pharmaceutical Co., Ltd.
Active
China
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