6-CHLORO-7-METHYLPURINE
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6-CHLORO-7-METHYLPURINE
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CAS No:
5440-17-5
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Formula:
C6H5ClN4
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Chemical Name:
6-CHLORO-7-METHYLPURINE
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Synonyms:
NSC 15192;7-METHYL-6-CHLOROPURINE;6-CHLORO-7-METHYLPURINE;6-Chloro-7-methyl-7H-purine
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CAS No:
Characteristics
43.6
1
light green solid
1.6±0.1 g/cm3
175-185ºC
321.7°C at 760 mmHg
148.4±28.7 °C
1.743
-20ºC Freezer
Safety Information
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, P501
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
6-CHLORO-7-METHYLPURINE Use and Manufacturing
To a 1L 3-necked round-bottom flask purged and maintained with an inert atmosphere of nitrogen was placed 6-chloro-9H-purine (15.4 g, 0.1 mol, 1 equiv) and tetrahydrofuran (155 mL) at 0 °C followed by the addition of MeMgCl (36.6 mL, 1.0M THF solution, 1.1 equiv) dropwise with stirring. The mixture was stirred at 0 °C for 30 min. To this was added iodomethane (42.6 g, 3 equiv) dropwise with stirring. The resulting solution was stirred at 50 °C in an oil bath for 5 h, quenched by the addition of 50 mL of aqueous NH
6-CHLORO-7-METHYLPURINE is a useful synthetic intermediate.