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Dihydralazine sulfate

Dihydralazine sulfate structure

CAS No:
7327-87-9
Formula:
C8H10N6.H2O4S
Chemical Name:
Dihydralazine sulfate
Synonyms:
Phthalazine,1,4-dihydrazinyl-,sulfate (1:1);Phthalazine,1,4-dihydrazino-,sulfate (1:1);1,4-Phthalazinedione,2,3-dihydro-,dihydrazone,sulfate (1:1);Depressan;1,4-Dihydrazinophthalazine sulfate;Dihydrazinophthalazine sulfate;Dihydralazine sulfate;Dihyzin
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Dihydralazine sulfate is an antihypertensive agent.

1,4-Dihydrazinophthalazine. An antihypertensive agent with actions and uses similar to those of HYDRALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p354)

Dihydralazine sulfate Basic Attributes

Molecular Weight：

288.28

Exact Mass：

288.064087

EC Number：

230-808-0

UNII：

1C2B1W91NK

DSSTox ID：

DTXSID10223501

Characteristics

PSA：

185

XLogP3：

2.17560

Boiling Point：

648.3°C at 760 mmHg

Flash Point：

345.9ºC

Water Solubility：

DMSO: soluble 1mg/mL

Storage Conditions：

-20°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

Precautionary statement(s)：

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 5 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

MeSH Entry Terms：

Depressan

Dihydralazine sulfate Use and Manufacturing

Ophthazin is an antihypertensive agent of the hydrazine class used during pregnancies in dialysis patients with familial mediterranean fever and cystinosis under hemodialysis.

Computed Properties

Molecular Weight:288.29
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:2
Exact Mass:288.06407406
Monoisotopic Mass:288.06407406
Topological Polar Surface Area:185
Heavy Atom Count:19
Complexity:248
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Vasodilators relax arteriolar smooth muscle and reduce peripheral resistance

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Compound Reserpine Tablets
Ingredients	This product is a compound preparation, and its components are: each tablet contains 0.032 mg of reserpine, 3.1 mg of hydrochlorothiazide, 1.0 mg of vitamin B6, 1.0 mg of calcium pantothenate, 30 mg of magnesium trisilicate, 30 mg of potassium chloride, 1.0 mg of vitamin B1, 4.2 mg of dihydralazine sulfate, and 2.1 mg of promethazine hydrochloride.
Indication	Patients taking reserpine should be careful because the addition of digitalis may cause sudden cardiac arrest or arrhythmia.
Specifications	Compound
Manufacturer	Hefei Limin Pharmaceutical Co., Ltd.

Compound Reserpine Tablets
Ingredients	This product is a compound preparation, and its components are: each tablet contains 0.032 mg of reserpine, 3.1 mg of hydrochlorothiazide, 1.0 mg of vitamin B6, 1.0 mg of calcium pantothenate, 30 mg of magnesium trisilicate, 30 mg of potassium chloride, 1.0 mg of vitamin B1, 4.2 mg of dihydralazine sulfate, and 2.1 mg of promethazine hydrochloride.
Indication	Patients taking reserpine should be careful because the addition of digitalis may cause sudden cardiac arrest or arrhythmia.
Specifications	Compound
Manufacturer	China Resources Double-Crane Pharmaceutical Co., Ltd.

Compound Lophatherum gracile tablets Ⅰ
Ingredients	Luobu Ma leaves, wild chrysanthemum, Stephania tetrandra, magnesium trisilicate, hydralazine sulfate, hydrochlorothiazide, promethazine hydrochloride, chlordiazepoxide, vitamin B1g, vitamin B6, calcium pantothenate.
Indication	-Atropine: can partially counteract the antihypertensive effect of Apocynum venetum leaves. -Diphenhydramine: can block the antihypertensive effect of Apocynum venetum leaves by more than 50%. Other antihypertensive drugs: Apocynum venetum can be used in combination with external Chinese medicine patches such as Li's Medicinal Patch, Jiangya Shen Patch, and Xuanya Patch to enhance the antihypertensive effect. For other drug interactions, please consult your doctor or pharmacist.
Specifications	Compound
Manufacturer	Henan Tiandi Pharmacy Co., Ltd.

See More Related Drugs

Registered Holders

Nantong Chanyoo Pharmatech Co., Ltd.

China
Active
China Resources Double-Crane Pharmaceutical Co., Ltd.

China
Active
Changzhou Wuxin Pharmaceutical Co., Ltd.

China
Active

See More Registered Holders