Chlorpyrifos-methyl

Chlorpyrifos-methyl is a general use organophosphate insecticide registered in 1985. It is used for the control of stored grain pests, weevils, moths, borers, beetles and mealworms, red fl our beetle, grain moth, for seed treatment. It is effective against rice stem borer, aphids, cutworms, plant and leaf hoppers, mole crickets, moths and stored grain pests. It is poorly soluble in water, moderately soluble in hexane and alcohols, and readily soluble in other organic solvents, such as acet

Preparation of pentachloropyridine 60 mL of 4 to 6 mesh activated carbon is immersed in 150 mL of an aqueous solution containing 1.5 g of cobalt chloride, and heated to distilled water to dryness to obtain a catalyst. Then, the catalyst was pretreated with chlorine gas, and the temperature was raised to 330°C in a nickel reaction tube. The vaporized pyridine, chlorine gas and nitrogen gas were thoroughly mixed, and the catalyst layer was reacted to obtain pentachloropyridine with a purity of 99.5%. Preparation of 2, 3, 5, 6-tetrachloropyridine 199g of acetonitrile and 35g of pentachloropyridine were heated and refluxed to completely dissolve. Then add 9.6g of zinc powder, and slowly add a solution of 15g of ammonium chloride and 40mL of water to the above mixture slowly. After the appropriate reaction time, add dilute hydrochloric acid and distill at 77-78°C to obtain tetrachloromethane Pyridine. Preparation of 3, 5, 6-trichloro-2-pyridinol A mixture of 217g of tetrachloropyridine, 868g of water and 128g of KOH was stirred and reacted at 95-100°C, and filtered while hot, so that the temperature of the filtrate was 85°C, and the filtrate was concentrated Sulfuric acid, which makes the pH value reach 3.5, is cooled to 50°C, and the filter cake is washed with hot water and dried. For the synthesis of 3, 5, 6-trichloro-2-pyridinol, please refer to the preparation method of chlorpyrifos. For the preparation of O, O-dimethylthiophosphoryl chloride, please refer to the preparation method of fenthion. For the synthesis of methyl chlorpyrifos, input 3, 5, 6-trichloro-2-pyridinol, sodium hydroxide and water, heat to make the solid matter completely disappear, and then add sodium chloride, sodium hydroxide, boric acid and benzyl group after cooling Triethylammonium chloride, 1-methylimidazole and dichloromethane, stir at room temperature, dropwise add O, O-dimethylthiophosphoryl chloride, drop after completion, heat up and reflux for 1 to 1.5 hours, cool and let stand Layer, washed with water, decompressed and prepared by desolvation.

Insecticide; acaricide.

Molecular Weight:322.5
XLogP3:4.3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:320.894984
Monoisotopic Mass:320.894984
Topological Polar Surface Area:72.7
Heavy Atom Count:16
Complexity:278
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes