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1,9-Dichlorononane

1,9-Dichlorononane structure

CAS No:
821-99-8
Formula:
C9H18Cl2
Chemical Name:
1,9-Dichlorononane
Synonyms:
Nonane,1,9-dichloro-;1,9-Dichlorononane;NSC 9477
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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Description

CLEAR YELLOW LIQUID

1,9-Dichlorononane Basic Attributes

Molecular Weight：

197.143

Exact Mass：

197.15

EC Number：

212-484-2

NSC Number：

9477

Characteristics

PSA：

XLogP3：

4.9

Density：

1.091 g/mL at 25ºC(lit.)

Boiling Point：

260 °C

Flash Point：

98ºC

Refractive Index：

n20/D 1.4599(lit.)

Water Solubility：

Insoluble in water.

Safety Information

wgk germany：

hazard class code：

R36/37/38

safety instructions：

26-37/39

Marks：

Xi: Irritant;

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (95.12%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 41 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

1,9-Dichlorononane Use and Manufacturing

Methods of Manufacturing

In a 500 ml eggplant type bottle, 1, 9-nonanediol (5.0 g, 31.2 mmol) was added.Dichloromethane (100 ml) and DMF (3 drops).Thionyl chloride (11.7 g, 98.3 mmol) was dissolved in dichloromethane (155 ml).In an ice bath, the solution of thionyl chloride is added dropwise into the eggplant type bottle.The reaction was overnight.The reaction mixture was washed with saturated sodium bicarbonate solution and then washed with saturated sodium chloride solution.The organic phase is dried over anhydrous sodium sulfate.Evaporation gave 4.0 g of 1, 9-dichlorononane (light yellow oil, yield 65percent).In a 500 ml eggplant type bottle, 1, 9-nonanediol (5.0 g, 31.2 mmol) was added.Dichloromethane (100 ml) and DMF (3 drops).Thionyl chloride (11.7 g, 98.3 mmol) was dissolved in dichloromethane (155 ml).In an ice bath, the solution of thionyl chloride is added dropwise into the eggplant type bottle.The reaction was overnight.The reaction mixture was washed with saturated sodium bicarbonate solution and then washed with saturated sodium chloride solution.The organic phase is dried over anhydrous sodium sulfate.Evaporation gave 4.0 g of 1, 9-dichlorononane (light yellow oil, yield 65percent).

Manufacturing Info：

Nonane, 1,9-dichloro-: INACTIVE

Computed Properties

Molecular Weight:197.14
XLogP3:4.9
Rotatable Bond Count:8
Exact Mass:196.0785560
Monoisotopic Mass:196.0785560
Heavy Atom Count:11
Complexity:56.6
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 1,9-Dichlorononane

Hangzhou Zentra Bio-Chemical Co., Ltd. Contact Supplier

CN
2 YRS

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Trader Supplier of pharmaceutical intermediates,excipients,plant extracts,food additives,CDMO,fine cheimcals,Octadecanedioic acid,Eicosanedioic Acid

1,9-DICHLORONONANE 821-99-8

CAS No.: 821-99-8

Grade: Pharmaceutical Grade

Content: 99%

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