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Roxithromycin

Roxithromycin structure

CAS No:
80214-83-1
Formula:
C41H76N2O15
Chemical Name:
Roxithromycin
Synonyms:
Erythromycin,9-[O-[(2-methoxyethoxy)methyl]oxime],(9E)-;Oxacyclotetradecane,erythromycin deriv.;RU 28965;Roxithromycin;Rulid;Roxithromycin A;Surlid;Rotramin;Assoral;Claramid;Overal;Forilin;Rossitrol;RU 965;Brilid;Roxeptin;Roxid;Roxxibid;Roxibest-A;Roxid-M;Roxacin;Xthrocin;Roxl 150;Roxo;Rulide;Biaxsig;Roxar;Roximycin;102483-87-4;1460313-72-7
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Roxithromycin is a semi-synthetic macrolide antibiotic.Target: AntibacterialRoxithromycin is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Roxithromycin is derived from erythromycin, containing the same 14-membered lactone ring. Roxithromycin prevents bacteria from growing, by interfering with their protein synthesis. Roxithromycin binds to the subunit 50S of the bacterial ribosome, and thus inhibits the translocation of

Semisynthetic derivative of erythromycin. It is concentrated by human phagocytes and is bioactive intracellularly. While the drug is active against a wide spectrum of pathogens, it is particularly effective in the treatment of respiratory and genital tract infections.

Roxithromycin Basic Attributes

Molecular Weight：

837.05

Exact Mass：

837.05

EC Number：

1308068-626-2

DSSTox ID：

DTXSID8041117

ATC Code：

J - Antiinfectives for systemic use

HScode：

2941500000

Characteristics

PSA：

217

XLogP3：

2.20960

Appearance：

white crystalline powder

Density：

1.3±0.1 g/cm3

Melting Point：

122-126 °C

Boiling Point：

864.7°C at 760 mmHg

Flash Point：

>110°(230°F)

Refractive Index：

1.535

Water Solubility：

soluble in water to 18µg/ml;chloroform: soluble 10mg/mL

Storage Conditions：

2-8°C

Specific rotation：

D25 -77.5 ±2° (c = 0.45 in chloroform)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

safety instructions：

26-24/25

RTECS Number：

KF4990000

Marks：

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 65 companies from 1 notifications to the ECHA C&L Inventory.|Danger|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P260, P263, P264, P270, P273, P281, P301+P312, P307+P311, P308+P313, P314, P321, P330, P391, P405, and P501

Drug Information

MeSH：

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

MeSH Entry Terms：

Biaxsig

Roxithromycin Use and Manufacturing

Methods of Manufacturing

Taking erythromycin as raw material, it reacts with hydroxylamine hydrochloride in triethylamine and methanol to form oxime, and then reacts with methoxyethoxymethyl chloride in acetone to obtain roxithromycin.

Uses

Semisynthetic erythromycin derivative. Antibacterial

Computed Properties

Molecular Weight:837.0
XLogP3:3.1
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:17
Rotatable Bond Count:13
Exact Mass:836.52456972
Monoisotopic Mass:836.52456972
Topological Polar Surface Area:217
Heavy Atom Count:58
Complexity:1310
Undefined Atom Stereocenter Count:18
Undefined Bond Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Erythromycin

Triethylamine

Hydroxylamine hydrochloride

Ethanol

Dimethylformamide

Price Analysis

Make your Roxithromycin purchase based on the price and market insights! ECHEMI provides professional market insights with prices for you to make a better choice. Learn more on Roxithromycin prices .

Drug Function and Efficacy

This product is a semi-synthetic 14-membered macrolide antibiotic. Its antibacterial spectrum and antibacterial effect are basically similar to those of erythromycin. Its effect on Gram-positive bacteria is slightly worse than that of erythromycin, but its effect on Legionella pneumophila is stronger than that of erythromycin. Its antimicrobial effect on Chlamydia pneumoniae, Mycoplasma pneumoniae, and Ureaplasma urealyticum is similar to or slightly stronger than that of erythromycin.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Roxithromycin Capsules
Ingredients	The main ingredient of this product is roxithromycin, and its chemical name is 9-[O-[(2-methoxyethoxy)-methyl]oxime]erythromycin.
Indication	1. It is not compatible with ergotamine, dihydroergotamine, bromocriptine, terfenadine, ketoconazole and cisapride. 2. It has little effect on the metabolism of aminophylline and has little effect on carbamazepine, warfarin, ranitidine and other antacids.
Specifications	75mg
Manufacturer	Hainan Sanye Pharmaceutical Factory Co., Ltd.

Roxithromycin Granules
Ingredients	Chemical name: 9-{O-[(2-methoxyethoxy)-methyl]-oxime}erythromycin.
Indication	Not yet clear.
Specifications	75mg

Roxithromycin Capsules
Ingredients	The main ingredient of this product is: Roxithromycin. Its chemical name is: 9-{O-[(2-methoxyethoxy)-methyl]-oxime}erythromycin. Molecular formula: C41H76N2O15 Molecular weight: 837.03
Indication	1. It should not be used in combination with ergotamine, dihydroergotamine, bromocriptine, terfenadine, ketoconazole and cisapride. 2. It has little effect on the metabolism of aminophylline and has little effect on carbamazepine, warfarin, ranitidine and other antacids.
Specifications	0.15 g (150,000 units)
Manufacturer	Suzhou Chung- HWA Chemical & Pharmaceutical Industrial Co., Ltd.

See More Related Drugs

Registered Holders

CENTURY PHARMACEUTICALS LTD

United States
Active
Huangshi Shixing Pharmaceutical Co.,Ltd.

Japan
Active
Zhejiang Guangke Pharmaceutical Co., Ltd.

China
Active

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