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Simethicone

Simethicone structure

CAS No:
8050-81-5
Chemical Name:
Simethicone
Synonyms:
Simethicone;Antifoam A;DC Antifoam A;Mylicon;Sentry Simethicone GS;Simiticone;Aligest Plus;KS 66;KS 66 (silicone);Dow Corning Antifoam A;Dow Antifoam A;SonoRx;Espumisan;Silfoam SE 2;Q 7-2587;Barcroft SIM-DC 100;Xiameter AFE 0100;Xiameter AFE 0100 AF Emul FG;Xiameter AFE 0100 Antifoam Emulsion Food Grade;Gas-X;1646-73-7;9006-05-7;39349-90-1
Categories:
Cosmetic Ingredient > Hair Conditioning

Description

Viscous, greyish-white, opalescent liquid. The PhEur 6.0 and USP 32 describe simethicone as a mixture of fully methylated linear siloxane polymers containing repeating units of the formula [–(CH3)2SiO–]n, stabilized with trimethylsiloxy endblocking units of the formula [(CH3)3 SiO–], and silicon dioxide. It contains not less than 90.5% and not more than 99.0% of the polydimethylsiloxane [–(CH3)2SiO–]n, and not less than 4.0% and not more than 7.0% of silicon dioxide. The PhEur 6.0 additionally

Simethicone Basic Attributes

Molecular Weight：

238.46100

Exact Mass：

238.05100

EC Number：

617-098-1

HScode：

3910000000

Characteristics

PSA：

52.60000

XLogP3：

1.56770

Density：

0.980 g/cm³

Boiling Point：

96.5ºC at 760 mmHg

Flash Point：

6.3ºC

Refractive Index：

n20/D 1.406

Water Solubility：

Practically insoluble in water, very slightly soluble or practically insoluble in anhydrous ethanol, practically insoluble in methanol, partly miscible with ethyl acetate, with methylene chloride, with methyl ethyl ketone and with toluene.

Storage Conditions：

Simethicone is generally regarded as a stable material when stored in the original unopened container. A shelf-life of 18 months from the date of manufacture is typical. However, some simethicone products have a tendency for the silicon dioxide to settle slightly and containers of simethicone should therefore be shaken thoroughly to ensure uniformity of contents before sampling or use. Simethicone should be stored in a cool, dry, location away from oxidizing materials.
Simethicone can be s

Vapor Pressure：

5 mm Hg ( 20 °C)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R36/37; R20

safety instructions：

S26; S36; S23

RTECS Number：

TQ2690000

Marks：

Xn; Xi

Stability/Shelf Life：

Retain their stability when exposed to extreme changes in temperature /Siloxane oils/

Precautionary statement(s)：

P264, P273, P280, P305+P351+P338, P337+P313, P501

Hazard Statements：

H319

Simethicone Use and Manufacturing

Simethicone is an oral anti-foaming agent used to reduce bloating, discomfort and pain caused by excess gas in the stomach or intestinal tract. Simethicone is a mixture of polydimethylsiloxane and hydrated silica gel.

Drug Function and Efficacy

Antifoaming agents used to treat various symptoms caused by excess gas in the gastrointestinal tract

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Simethicone emulsion
Specifications	40mg/ml

Simethicone emulsion
Ingredients	The main ingredients are: Simethicone, the chemical name is: a-(trimethylsilyl)-w-methyl poly[oxy(dimethylsilylene)] and silicon dioxide complex. The chemical structure is the molecular formula: (CH3)3Si[-O-Si(CH3)2]nCH3SiO2
Indication	No interactions between simethicone and other drugs have been found so far.
Specifications	40 mg/mL

Simethicone emulsion
Specifications	40mg/ml

See More Related Drugs

Registered Holders

RIOCARE INDIA PRIVATE LTD

United States
Active
DuPont (Shenzhen) Investment Co., Ltd.

China
Active
Yuanda Medical Nutrition Science (Wuhan) Co., Ltd.

China
Active

See More Registered Holders

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High Quality Simethicone CAS NO.8050-81-5

CAS No.: 8050-81-5

Grade: Industrial Grade

Content: 99%

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POLYDIMETHYLSILOXANE 8050-81-5

CAS No.: 8050-81-5

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Content: 99%

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Guide of Simethicone

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Learn More Other Chemicals

Simethicone

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