Simethicone
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Simethicone
structure -
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CAS No:
8050-81-5
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Chemical Name:
Simethicone
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Synonyms:
Simethicone;Antifoam A;DC Antifoam A;Mylicon;Sentry Simethicone GS;Simiticone;Aligest Plus;KS 66;KS 66 (silicone);Dow Corning Antifoam A;Dow Antifoam A;SonoRx;Espumisan;Silfoam SE 2;Q 7-2587;Barcroft SIM-DC 100;Xiameter AFE 0100;Xiameter AFE 0100 AF Emul FG;Xiameter AFE 0100 Antifoam Emulsion Food Grade;Gas-X;1646-73-7;9006-05-7;39349-90-1
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CAS No:
Description
Viscous, greyish-white, opalescent liquid. The PhEur 6.0 and USP 32 describe simethicone as a mixture of fully methylated linear siloxane polymers containing repeating units of the formula [–(CH3)2SiO–]n, stabilized with trimethylsiloxy endblocking units of the formula [(CH3)3 SiO–], and silicon dioxide. It contains not less than 90.5% and not more than 99.0% of the polydimethylsiloxane [–(CH3)2SiO–]n, and not less than 4.0% and not more than 7.0% of silicon dioxide. The PhEur 6.0 additionally
Characteristics
52.60000
1.56770
0.980 g/cm3
96.5ºC at 760 mmHg
6.3ºC
n20/D 1.406
Practically insoluble in water, very slightly soluble or practically insoluble in anhydrous ethanol, practically insoluble in methanol, partly miscible with ethyl acetate, with methylene chloride, with methyl ethyl ketone and with toluene.
Simethicone is generally regarded as a stable material when stored
in the original unopened container. A shelf-life of 18 months from
the date of manufacture is typical. However, some simethicone
products have a tendency for the silicon dioxide to settle slightly and
containers of simethicone should therefore be shaken thoroughly to
ensure uniformity of contents before sampling or use. Simethicone
should be stored in a cool, dry, location away from oxidizing
materials.
Simethicone can be s
5 mm Hg ( 20 °C)
Safety Information
NONH for all modes of transport
3
R36/37; R20
S26; S36; S23
TQ2690000
Xn; Xi
Retain their stability when exposed to extreme changes in temperature /Siloxane oils/
P264, P273, P280, P305+P351+P338, P337+P313, P501
H319
Simethicone Use and Manufacturing
Simethicone is an oral anti-foaming agent used to reduce bloating, discomfort and pain caused by excess gas in the stomach or intestinal tract. Simethicone is a mixture of polydimethylsiloxane and hydrated silica gel.
Drug Function and Efficacy
Antifoaming agents used to treat various symptoms caused by excess gas in the gastrointestinal tract
Registered Holders
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RIOCARE INDIA PRIVATE LTD
Active![United States]()
United States
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DuPont (Shenzhen) Investment Co., Ltd.
Active![China]()
China
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Yuanda Medical Nutrition Science (Wuhan) Co., Ltd.
Active![China]()
China
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