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Dihydroergotoxine mesylate

Dihydroergotoxine mesylate structure

CAS No:
8067-24-1
Formula:
CH4O3S.Unspecified
Chemical Name:
Dihydroergotoxine mesylate
Synonyms:
Ergotoxine,dihydro-,methanesulfonate (1:1);Hydergine;Ergotoxine,dihydro-,monomethanesulfonate (salt);Indolo[4,3-fg]quinoline,ergotoxine deriv.;8H-Oxazolo[3,2-a]pyrrolo[2,1-c]pyrazine,ergotoxine deriv.;Dihydroergotoxine methanesulfonate;CCK 179;Hydergin;Dihydroergotoxin methanesulfonate;Dihydroergotoxine mesylate;Dihydroergotoxin mesylate;Circanol;Ischelium;Redergin;Co-dergocrine mesylate;Codergocrine methanesulfonate;Ergoloid mesylates;Coristin;Codergine mesylate;Co-dercrine mesylate;Novofluen;Dacoren;Ergohydrin;Ergoplus;Trigot;Sponsin;Dulcion;Ergodesit;Perenan;Progeril;Decril;Deapril ST;Hydergyne;Orphol;Dihydroergotoxine mesilate;Alkergot;Deapril;Gerimal;8031-73-0;11006-63-6;12645-43-1;42615-51-0;52655-92-2
Categories:
Analytical Chemistry > Standard

Description

Dihydroergotoxine mesylate is a complex of closely related alkaloid salts; Binds with high affinity to the GABAA receptor Cl- channel, producing an allosteric interaction with the benzodiazepine site.IC50 value:Target: Dihydroergotoxine mesylate also interacts with central dopaminergic, serotonergic and adrenergic (α1) receptors. Dihydroergotoxine mesylate displays antiproliferative activity in vitro (IC50 = 18 - 38 μM in prostate cancer cells) and exhibits cognition-enhancing, anticonvu

Dihydroergotoxine mesylate Basic Attributes

Molecular Weight：

423.53

Exact Mass：

233.066363

HScode：

3003490000

Characteristics

PSA：

131.11000

XLogP3：

2.53850

Density：

1.34g/cm3

Boiling Point：

899.5ºC at 760 mmHg

Flash Point：

497.8ºC

Refractive Index：

1.66

Storage Conditions：

Store at RT

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

1544

hazard class code：

safety instructions：

53-36/37/39-45

RTECS Number：

KE8800000

Marks：

Dihydroergotoxine mesylate Use and Manufacturing

Cognition adjuvant.

Drug Function and Efficacy

It changes the signal transmission of the central nervous system, has an stimulatory effect on dopamine receptors and 5-hydroxytryptamine receptors, has a blocking effect on α-adrenergic receptors, improves damaged brain metabolic function, shortens cerebral circulation time, improves symptoms of intellectual decline, stabilizes cerebral vascular tension, and prevents migraines.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Dihydroergoline Mesylate Injection
Ingredients	Dihydroergoceptin mesylate is composed of equal proportions of dihydroergocornine mesylate, dihydroergocryptine mesylate (there are two isomers, dihydro-α-ergocryptine mesylate and dihydro-β-ergocryptine mesylate, in a ratio of 2:1) and dihydroergoline mesylate.
Indication	This product can enhance the effects of antihypertensive drugs and nitro drugs. When used in combination with cytochrome P450 inhibitors such as macrolide antibiotics (such as erythromycin, clindamycin, triacetyloleandomycin, spiramycin, josamycin), azole antifungal agents (such as ketoconazole, itraconazole), protease inhibitors (such as ritonavir, indinavir) or cimetidine, the drug concentration of this product can be increased, thereby causing peripheral vasoconstriction, so it should be avoided.
Specifications	1ml: 0.3mg
Manufacturer	Hunan Wzt Pharmaceutical Co., Ltd.

Dihydroergotamine mesylate injection
Ingredients	Dihydroergoceptin mesylate is composed of equal proportions of dihydroergocornine mesylate, dihydroergocryptine mesylate (there are two isomers, dihydro-α-ergocryptine mesylate and dihydro-β-ergocryptine mesylate, in a ratio of 2:1) and dihydroergoline mesylate.
Indication	This product can enhance the effects of antihypertensive drugs and nitro drugs. When used in combination with cytochrome P450 inhibitors such as macrolide antibiotics (such as erythromycin, clindamycin, triacetyloleandomycin, spiramycin, josamycin), azole antifungal agents (such as ketoconazole, itraconazole), protease inhibitors (such as ritonavir, indinavir) or cimetidine, the drug concentration of this product can be increased, thereby causing peripheral vasoconstriction, so it should be avoided.
Specifications	1ml:0.3mg
Manufacturer	Hainan Bikai Pharmaceutical Co., Ltd.

Dihydroergoline Mesylate Injection
Ingredients	Dihydroergoline mesylate is a total base composed of dihydroergoline mesylate, dihydroergoline mesylate (alpha type and beta type), and dihydroergoline mesylate, each accounting for about 1/3.
Indication	1. When used in combination with cyclosporine, the pharmacokinetics of cyclosporine will be changed. 2. When dopamine is used in combination with dihydroergotamine, it can induce peripheral vasospasm, especially vasoconstriction of distal limbs.
Specifications	1ml:0.3mg
Manufacturer	Hubei Jinyao Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

CURIA Italy SRL

United States
Active
Curia (Beijing) Pharmaceutical Information Consulting Co., Ltd.

China
Active
Guangzhou Greensyn Pharma Co., Ltd.

China
Active

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CAS No.: 8067-24-1

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Manufacturer Supply High Quality 99% ERGOLOID MESYLATES CAS 8067-24-1 from Yihang Company

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Guide of Dihydroergotoxine mesylate

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
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