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Calcium levofolinate

Calcium levofolinate structure

CAS No:
80433-71-2
Formula:
C20H23N7O7.Ca
Chemical Name:
Calcium levofolinate
Synonyms:
L-Glutamic acid,N-[4-[[[(6S)-2-amino-5-formyl-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-,calcium salt (1:1);L-Glutamic acid,N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-,calcium salt (1:1),(S)-;L-Glutamic acid,N-[4-[[[(6S)-2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl]methyl]amino]benzoyl]-,calcium salt (1:1);(S)-Leucovorin calcium salt (1:1);Calcium (6S)-folinate;Levoleucovorin calcium;Isovorin;Calcium levofolinate;5-Formyl-(6S)-tetrahydrofolate calcium salt;L-Folinic acid calcium salt;CL 307782;Elvorine;70954-47-1
Categories:
Active Pharmaceutical Ingredients > Vitamins and Minerals Medicines

Description

Levoleucovorin calcium is the calcium salt of Levoleucovorin, which is the enantiomerically active form of folinic acid.IC50 value: Target: Levoleucovorin is used to treat or prevent toxic effects of methotrexate in people who have received methotrexate to treat bone cancer. Levoleucovorin is also used in combination chemotherapy with fluorouracil (5-FU) to treat colorectal cancer that has spread to other parts of the body. This medicine only treats the symptoms of colorectal cancer and

Calcium levofolinate Basic Attributes

Molecular Weight：

511.5

Exact Mass：

511.112823

EC Number：

1806241-263-5

Characteristics

PSA：

221

Melting Point：

240-2500C (dec)

Water Solubility：

DMSO « 1 (mg/mL)

Specific rotation：

D20 -15.1° (c = 1.82)

Safety Information

Stability/Shelf Life：

Bulk: Calcium leucovorin was stable in bulk form after 4 weeks storage at 60 ° C (HPLC). Solution: Leucovorin in 0.1 N NaOH (pH 13) and in deionized water (pH6) was stable at room temperature under laboratory illumination for at least 24 hours (HPLC).

Calcium levofolinate Use and Manufacturing

intermediate from Folic Acid metabolism

Drug Function and Efficacy

Folinic acid is a mixture of diastereoisomers of the 5-formyl derivative of tetrahydrofolate (THF), and its biologically active substance is the levorotatory isomer called levofolinic acid. L-folinic acid (L-5-formyltetrahydrofolate) is rapidly metabolized to L-5-methyltetrahydrofolate, and can be metabolized to 5,10-methylenetetrahydrofolate through other pathways, which can stabilize the binding of deoxyfluorouracil nucleotides to thymidylate synthase, thereby enhancing the inhibitory effect on the enzyme. Folinic acid can offset the therapeutic effect and toxicity of hydrochloric acid antagonists (such as methotrexate) that inhibit dihydrofolate reductase, and can enhance the efficacy and toxicity of fluoropyrimidines (such as 5-fluorouracil) in tumor treatment.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Calcium folinate for injection
Ingredients	The main ingredient of this product is calcium folinate, and its chemical name is (-)-N-[4[[[(6S)-2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pterydinyl]methyl]amino]benzoyl]-L-glutamic acid calcium salt pentahydrate. Its auxiliary material is mannitol.
Indication	(1) Drugs that cannot be used in combination Drug name Clinical symptoms, treatment methods Mechanism, risk factors Tegafur may cause early severe hematological toxicity and gastrointestinal reactions such as diarrhea and oral endocarditis, so they cannot be used at the same time. They cannot be used at the same time for at least 7 days. It hinders the catabolism of fluorouracil, and the blood fluorouracil level is significantly increased. (2) Precautions for combined use Drug name Clinical symptoms, treatment methods Mechanism, risk factors Phenytoin sometimes causes language disorders, movement disorders, impaired consciousness and other symptoms of phenytoin poisoning. The mechanism is unknown. Fluorouracil can increase the blood concentration of phenytoin Potassium Benzylpropionate Coumarin Potassium Fluorouracil sometimes enhances the action of potassium Benzylpropionate Coumarin The mechanism is unknown Other chemotherapy and radiotherapy sometimes enhance hematological toxicity and gastrointestinal reactions Adverse reactions
Specifications	0.15g (based on folinic acid)
Manufacturer	Guangdong Lingnan Pharmaceutical Co., Ltd.

Calcium folinate for injection
Specifications	50mg (as folinic acid)
Manufacturer	Chongqing Huapont Pharmaceutical Co., Ltd.

Calcium folinate for injection
Ingredients	The main ingredient of this product is calcium folinate, and its chemical name is (-)-N-[4[[[(6S)-2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pterydinyl]methyl]amino]benzoyl]-L-glutamic acid calcium salt pentahydrate. Its auxiliary material is mannitol.
Indication	(1) Drugs that cannot be used in combination Drug name Clinical symptoms, treatment methods Mechanism, risk factors Tegafur may cause early severe hematological toxicity and gastrointestinal reactions such as diarrhea and oral endocarditis, so they cannot be used at the same time. They cannot be used at the same time for at least 7 days. It hinders the catabolism of fluorouracil, and the blood fluorouracil level is significantly increased. (2) Precautions for combined use Drug name Clinical symptoms, treatment methods Mechanism, risk factors Phenytoin sometimes causes language disorders, movement disorders, impaired consciousness and other symptoms of phenytoin poisoning. The mechanism is unknown. Fluorouracil can increase the blood concentration of phenytoin Potassium Benzylpropionate Coumarin Potassium Fluorouracil sometimes enhances the action of potassium Benzylpropionate Coumarin The mechanism is unknown Other chemotherapy and radiotherapy sometimes enhance hematological toxicity and gastrointestinal reactions Adverse reactions
Specifications	25mg (as folinic acid)
Manufacturer	Guangdong Lingnan Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

MERCK AND CIE KMG

United States
Active
GMT Fine Chemicals SA

Switzerland
Active
Chongqing Shengkai Pharmaceutical Co., Ltd.

China
Active

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