Fentiapril
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Fentiapril
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CAS No:
80830-42-8
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Formula:
C13H15NO4S2
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Chemical Name:
Fentiapril
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Synonyms:
4-Thiazolidinecarboxylic acid,2-(2-hydroxyphenyl)-3-(3-mercapto-1-oxopropyl)-,(2R,4R)-;4-Thiazolidinecarboxylic acid,2-(2-hydroxyphenyl)-3-(3-mercapto-1-oxopropyl)-,(2R-cis)-;(2R,4R)-2-(2-Hydroxyphenyl)-3-(3-mercapto-1-oxopropyl)-4-thiazolidinecarboxylic acid;SA 446;Fentiapril;Rentiapril
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CAS No:
Description
Rentiapril is an orally active angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity[1][2].
Rentiapril is a potent angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Rentiapril competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Rentiapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.
Characteristics
104
1.67720
1.451g/cm3
146-148 °C @ Solvent: Ethyl acetate
553.7ºC at 760 mmHg
288.7ºC
1.66
Drug Information
A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility. (See all compounds classified as Angiotensin-Converting Enzyme Inhibitors.)|Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)
2-(2'-hydroxyphenyl)-3-(3-mercaptopropanoyl)-4-thiazolidine carboxylic acid
Computed Properties
Molecular Weight:313.4
XLogP3:1.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:313.04425031
Monoisotopic Mass:313.04425031
Topological Polar Surface Area:104
Heavy Atom Count:20
Complexity:379
Defined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes