 Home > Encyclopedia > Concanamycin A

Concanamycin A

Concanamycin A structure

CAS No:
80890-47-7
Formula:
C46H75NO14
Chemical Name:
Concanamycin A
Synonyms:
Oxacyclooctadeca-3,5,13,15-tetraen-2-one,18-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-4-[[4-O-(aminocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]tetrahydro-2-hydroxy-5-methyl-6-(1E)-1-propen-1-yl-2H-pyran-2-yl]-2-hydroxy-1-methylbutyl]-9-ethyl-8,10-dihydroxy-3,17-dimethoxy-5,7,11,13-tetramethyl-,(3Z,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-;Concanamycin A;Oxacyclooctadeca-3,5,13,15-tetraen-2-one,18-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-4-[[4-O-(aminocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]tetrahydro-2-hydroxy-5-methyl-6-(1E)-1-propenyl-2H-pyran-2-yl]-2-hydroxy-1-methylbutyl]-9-ethyl-8,10-dihydroxy-3,17-dimethoxy-5,7,11,13-tetramethyl-,(3Z,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-;Oxacyclooctadecane,concanamycin A deriv.;(3Z,5E,7R,8R,9S,10S,11R,13E,15E,17S,18R)-18-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-4-[[4-O-(Aminocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]tetrahydro-2-hydroxy-5-methyl-6-(1E)-1-propen-1-yl-2H-pyran-2-yl]-2-hydroxy-1-methylbutyl]-9-ethyl-8,10-dihydroxy-3,17-dimethoxy-5,7,11,13-tetramethyloxacyclooctadeca-3,5,13,15-tetraen-2-one;[7R-[3Z,5E,7R*,8R*,9S*,10S*,11R*,13E,15E,17S*,18R*[1S*,2R*,3S*[2R*,4R*,5S*,6R*(E)]]]-18-[3-[4-[[4-O-(Aminocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]tetrahydro-2-hydroxy-5-methyl-6-(1-propenyl)-2H-pyran-2-yl]-2-hydroxy-1-methylbutyl]-9-ethyl-8,10-dihydroxy-3,17-dimethoxy-5,7,11,13-tetramethyloxacyclooctadeca-3,5,13,15-tetraen-2-one;66771-59-3
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Concanamycin A (Antibiotic X 4357B; Concanamycin; X 4357B) is a macrolide antibiotic and a specific vacuolar type H+-ATPase (V-ATPase) inhibitor[1].

Concanamycin A Basic Attributes

Molecular Weight：

866.09

Exact Mass：

866.09

EC Number：

2017-001-1

Characteristics

PSA：

225.92000

XLogP3：

3.88

Density：

1.2±0.1 g/cm3

Melting Point：

179-180 °C @ Solvent: Dichloromethane, Ethanol

Boiling Point：

966.4±65.0 °C at 760 mmHg

Flash Point：

538.3±34.3 °C

Refractive Index：

1.555

Storage Conditions：

−20°C

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

UN 3462 6.1/PG 2

wgk germany：

hazard class code：

26/27/28-36

safety instructions：

26-36/37/39-45

RTECS Number：

CB9732000

Marks：

T+

Precautionary statement(s)：

P260-P264-P280-P284-P301 + P310-P302 + P350

Hazard Statements：

H300 + H310 + H330-H319

GHS Classification：

|Danger|H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]|P260, P262, P264, P270, P271, P280, P284, P301+P310, P302+P350, P304+P340, P305+P351+P338, P310, P320, P321, P322, P330, P337+P313, P361, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 39 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)|Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)

MeSH Entry Terms：

concanamycin A

Concanamycin A Use and Manufacturing

Concanamycin A is the major analogue of the concanamycin complex produced by Streptomyces sp.. It hasbeen shown to act as a potent and specific vacuolar-ATPase inhibitor. Concanamycin A inhibits the acidification of organelles and blocks cell surface expression of viral envelope glycoproteins without affecting their synthesis. It also interferes with intracellular protein trafficking and inhibits perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity. Concanamycins are structurally related to the bafilomycins.

Computed Properties

Molecular Weight:866.1
XLogP3:6
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:14
Rotatable Bond Count:12
Exact Mass:865.51875607
Monoisotopic Mass:865.51875607
Topological Polar Surface Area:226
Heavy Atom Count:61
Complexity:1580
Undefined Atom Stereocenter Count:18
Undefined Bond Stereocenter Count:5
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Concanamycin A

Shaanxi Cuikang Pharmaceutical Technolog Contact Supplier

CN
4 YRS

Business licensed Certified factory

Manufactory Supplier of Cosmetics raw materials,Pesticide intermediate,Photoelectric material,pharmaceutical intermediates,Raw materials for food and health products,Polymer materials,Fine Chemicals,Synthetic customization

concanamycin A from streptomyces species

CAS No.: 80890-47-7

Grade: Industrial Grade

Content: 98%

Inquiry
Henan Lihao Chem Plant Limited Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of PVC resin,pvc paste resin,melamine

Concanamycin A 99% white powder kanbei

CAS No.: 80890-47-7

Grade: Industrial Grade

Content: 99%

Inquiry