2-P-TOLYL-4,5,6,7-TETRAHYDRO-OXAZOLO[5,4-C]PYRIDINE

Compound 36A (3.9 g, 17.4 mmol) was dissolved in 60 mL of acetic acid.0.4 g of palladium on carbon catalyst was added.After the reaction liquid is replaced with three hydrogens in a hydrogen reaction vessel, The reaction was carried out at 50 psi for 48 h at room temperature. Filter to remove the catalyst, The solvent was dried under reduced pressure and purified by dichloromethane:methanol = 5:1 to afford compound 36B(1.48 g, 64percent yield).To a solution of 6-(phenylmethyl)-5, 6, 7, 8-tetrahydro-1 , 6-naphthyridine (Intermediate 24) (36 g, 0.16 mol) in acetic acid (500 ml.) was added 10percent Pd/C (6 g) and the mixture was hydrogenated under 1 atmosphere of hydrogen for 2 hours at 50 to 603-bromo-5, 6, 7, 8-tetrahydro-1, 6- naphthyridine (0.5 g, 2.347 mmol) in EtOH (30 mL) with 10percent Pd/C (40 mg) was hydrogenated at 55 psi for 3.5 h. MS (ESI) m/z: 135.0 (M+H)

Molecular Weight:134.18
XLogP3:0.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:134.084398327
Monoisotopic Mass:134.084398327
Topological Polar Surface Area:24.9
Heavy Atom Count:10
Complexity:114
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes