4-(4'-Bromophenyl)piperidine

To a solution of 4-(4-bromophenyl)-1, 2, 3, 6-tetrahydropyridine 17 (0.90 g, 3.78mmol) in dry MeOH (20 mL) and Et3N (2 ml) was added RhIC catalyst (0.060 g, J. Bishop & Co. Platinum). The resulting reaction mixture was stirred at room temperature in a hydrogen atmosphere (100 psi) for 24 h. The mixture was filtered through a cake of CELITETM (Sigma Aldrich, St. Louis, MO), and the filtrate was concentrated to give the title compound as a white solid (0.91 g. 98percent). ‘H NMR (400 MHz, MeOD) 3; 1.55-159 (2H, m). 1.61-1.70 (2H, m), 2.55-2.56 (IH, m), 264-2.7C (2H. m), 3.09-3.06 (2H, m). 7.13 (2H. J = 8.0. d), 7.31 (2H, J = 8.0. d). ‘3CNMR(100 MHz, MeOD) 3: 32, 7, 41.4, 45.6. 119.4. 126.4, 128, 2, 128.5, 131.2, 145.3, m/z (ESI. MF1) 241.

Molecular Weight:240.14
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:239.03096
Monoisotopic Mass:239.03096
Topological Polar Surface Area:12
Heavy Atom Count:13
Complexity:146
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes