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α-Dihydroartemisinin

α-Dihydroartemisinin structure

CAS No:
81496-81-3
Formula:
C15H24O5
Chemical Name:
α-Dihydroartemisinin
Synonyms:
3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-ol,decahydro-3,6,9-trimethyl-,(3R,5aS,6R,8aS,9R,10R,12R,12aR)-;3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-ol,decahydro-3,6,9-trimethyl-,[3R-(3α,5aβ,6β,8aβ,9α,10β,12β,12aR*)]-;(3R,5aS,6R,8aS,9R,10R,12R,12aR)-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-ol;α-Dihydroartemisinin;DHQHS 1;1236363-40-8;1268483-98-2
Categories:
Active Pharmaceutical Ingredients > Antiparasitic Drugs

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Description

White needle like crystal

Dihydroartemisinin (DHA) is an artemisinin derivative.|.alpha.-dihydroartemisinin is an Antimalarial.

α-Dihydroartemisinin Basic Attributes

Molecular Weight：

284.35

Exact Mass：

284.35

EC Number：

1308068-626-2

UNII：

X0UIV26ABX

DSSTox ID：

DTXSID5045962

ATC Code：

P01BF05|P - Antiparasitic products, insecticides and repellents

Characteristics

PSA：

57.15000

XLogP3：

2.60

Density：

1.3±0.1 g/cm3

Boiling Point：

375.6±42.0 °C at 760 mmHg

Flash Point：

181.0±27.9 °C

Refractive Index：

1.543

Storage Conditions：

2-8°C

Vapor Pressure：

3.52E-07mmHg at 25°C

Safety Information

GHS Classification：

|Warning|H242 (100%): Heating may cause a fire [Danger Self-reactive substances and mixtures; Organic peroxides]|P210, P220, P234, P273, P280, P370+P378, P391, P403+P235, P411, P420, and P501|Aggregated GHS information provided by 2 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Drug Indication：

Eurartesim is indicated for the treatment of uncomplicated Plasmodium falciparum malaria in adults, children and infants 6 months and over and weighing 5 kg or more.Consideration should be given to official guidance on the appropriate use of antimalarial agents.|Treatment of uncomplicated malaria caused by Plasmodium falciparum

MeSH：

Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585) (See all compounds classified as Antimalarials.)

MeSH Entry Terms：

3alpha-hydroxydeoxydihydroartemisinin

α-Dihydroartemisinin Use and Manufacturing

Uses

antimalarial, antiinflammatory

Use Classification：

Human drugs -> Eurartesim -> EMA Drug Category|Antiprotozoals -> Human pharmacotherapeutic group|Human drugs -> Rare disease (orphan)|Human Drugs -> EU pediatric investigation plans

Computed Properties

Molecular Weight:284.35
XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Exact Mass:284.16237386
Monoisotopic Mass:284.16237386
Topological Polar Surface Area:57.2
Heavy Atom Count:20
Complexity:415
Defined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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