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Home > Encyclopedia > 2-Ethoxyaniline

2-Ethoxyaniline

2-Ethoxyaniline structure

2-Ethoxyaniline 

structure
  • CAS No:

    94-70-2

  • Formula:

    C8H11NO

  • Chemical Name:

    2-Ethoxyaniline

  • Synonyms:

    Benzenamine,2-ethoxy-;o-Phenetidine;2-Ethoxybenzenamine;2-Aminophenetole;2-Ethoxyaniline;o-Ethoxyaniline;2-Ethoxyphenylamine;NSC 9818;o-Ethoxylaniline;2-Aminophenyl ethyl ether

  • Categories:

    Organic Chemistry  >  Ethers and Derivatives

Description

deep red liquid


Reddish brown oily liquid. (NTP, 1992)


Reddish brown oily liquid. (NTP, 1992)|Used in the manufacture of acetophenetidin.

2-Ethoxyaniline Basic Attributes

137.18

137.18

637069

202-356-4

I76155S2AA

9818

2311

DTXSID5025863

29222200

Characteristics

35.2

1.62

Deep red Liquid

1.0508 g/cm3 @ Temp: 20 °C

<-21 °C

232.5 °C

177 °F

1.545

H2O: 0.5-1.0 g/100 mL at 24.5 ºC

Store at +15°C to +25°C.

1 mm Hg ( 67 °C)

Oral-Mouse LDL0: 600 mg/kg

Open flame is flammable; emit toxic aniline gas when heated

This compound is very sensitive to exposure to light and air. (NTP, 1992). Slightly soluble in water.

Amines, Aromatic

O-PHENETIDINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Safety Information

III

6.1

UN 2311 6.1/PG 3

2

23/24/25-33

28-36/37-45-28A

SI6465300

T,Xi

The warehouse is ventilated, low temperature and dry; stored and transported separately from food materials

Irritant

P261-P280-P301 + P310-P311

H301-H311-H331-H373

This chemical is probably combustible. (NTP, 1992)

|Danger|H301: Toxic if swallowed [Danger Acute toxicity, oral]|P260, P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P311, P312, P314, P321, P322, P330, P361, P363, P403+P233, P405, and P501|H301 (98.86%): Toxic if swallowed [Danger Acute toxicity, oral]|Aggregated GHS information provided by 88 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should protect this chemical from exposure to light. Keep the container tightly closed under an inert atmosphere, and store under refrigerated temperatures. STORE AWAY FROM SOURCES OF IGNITION. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Toxicity

moderately toxic

Drug Information

SYMPTOMS: Exposure to this compound may cause cyanosis, hypothermia, headache, drowsiness, vomiting, irritation of the alimentary tract and nephritis. ACUTE/CHRONIC HAZARDS: This compound and its vapors may cause irritation of the eyes, skin and mucous membranes. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Aminophenetole

2-Ethoxyaniline Use and Manufacturing

Methods of Manufacturing

The reaction of nitrochlorobenzene with ethanol and caustic soda produces o-nitrophenyl ether ([610-67-3]), which is then reduced to o-ethoxyaniline.

Uses

manufacture of dyes.

Benzenamine, 2-ethoxy-: ACTIVE

Computed Properties

Molecular Weight:137.18
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:137.084063974
Monoisotopic Mass:137.084063974
Topological Polar Surface Area:35.2
Heavy Atom Count:10
Complexity:95.3
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Downstream Products

Recommended Suppliers of 2-Ethoxyaniline

  • China CN

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    CAS No.: 94-70-2
    Grade: Industrial Grade
    Content: 99%
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