Lactide
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Lactide
structure -
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CAS No:
95-96-5
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Formula:
C6H8O4
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Chemical Name:
Lactide
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Synonyms:
1,4-Dioxane-2,5-dione,3,6-dimethyl-;p-Dioxane-2,5-dione,3,6-dimethyl-;Lactide;Lactic acid,bimol. cyclic ester;3,6-Dimethyl-1,4-dioxane-2,5-dione;3,6-Diketo-2,5-dimethyl-1,4-dioxane;3,6-Dimethyl-p-dioxane-2,5-dione;2,5-Dioxo-3,6-dimethyl-1,4-dioxane;Propanoic acid,2-hydroxy-,bimol. cyclic ester;3,6-Dimethyl-2,5-dioxo-1,4-dioxane;2,5-Dimethyl-3,6-dioxo-1,4-dioxane;Dilactide;DL-Lactide;Lactoyl lactic acid;Purasorb DL;NSC 403080;rac-Lactide;Novalact;dl-Dilactide;DL-Dilactide;Dimethylglycolide;D,L-Lactide;Olygos DMR;Ingeo M 700;615-95-2;51019-72-8;87760-46-1;116559-43-4;137566-94-0;153381-12-5;219616-64-5;340821-71-8;612845-77-9;1310566-98-3;1351306-95-0;1415890-67-3;2129300-88-3;2324093-62-9
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CAS No:
Characteristics
52.6
0.6
White crystalline powder
1.2±0.1 g/cm3
129 °C
138ºC(8 torr)
150.6±18.8 °C
1.429
Refrigerator (+4ºC)
Safety Information
NONH for all modes of transport
2
R36/37/38
S26-S37/39
JH1100000
Xi:Irritant;
P305 + P351 + P338
H319
|Warning|H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]|P264, P280, P305+P351+P338, and P337+P313|Aggregated GHS information provided by 52 companies from 4 notifications to the ECHA C&L Inventory.
Lactide Use and Manufacturing
DL-Lactide is used to produce 2-hydroxy-propionic acid 1-(1-phenyl-ethoxycarbonyl)-ethyl ester. It acts as an important raw material and an intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyes. It is involved in enzymatic alcoholysis to produce both alkyl (R)-lactates and alkyl (S,S)-lactyllactates.DL-Lactide is often used as a protective layer in wound coatings, or as anchors, screws or mesh in surgery, since it degrades in about six months to the innocuous lactic acid. Enzymatic alcoholysis of this racemic lactide catalyzed by commercial Novozym® 435 produces both alkyl (R)-lactates and alkyl (S,S)-lactyllactates in good yield and high enantiopurity.
1,4-Dioxane-2,5-dione, 3,6-dimethyl-: ACTIVE
Computed Properties
Molecular Weight:144.12
XLogP3:0.6
Hydrogen Bond Acceptor Count:4
Exact Mass:144.04225873
Monoisotopic Mass:144.04225873
Topological Polar Surface Area:52.6
Heavy Atom Count:10
Complexity:155
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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