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Tetraethylthiuram disulfide

Tetraethylthiuram disulfide structure

CAS No:
97-77-8
Formula:
C10H20N2S4
Chemical Name:
Tetraethylthiuram disulfide
Synonyms:
Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2),N,N,N′,N′-tetraethyl-;Disulfide,bis(diethylthiocarbamoyl);Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2),tetraethyl-;N,N,N′,N′-Tetraethylthioperoxydicarbonic diamide ([(H2N)C(S)]2S2);Abstensil;Abstinyl;Alcophobin;Antabuse;Antadix;Antaethyl;Antalcol;Antietanol;Antietil;Antikol;Aversan;Bis(N,N-diethylthiocarbamoyl) disulfide;Bis(diethylthiocarbamoyl) disulfide;Contralin;Cronetal;Disulfiram;Esperal;Etabus;Ethyl Thiram;Ethyl Thiurad;Ethyl Tuex;Exhorran;Noxal;Refusal;Stopetyl;TETD;Tetradine;Tetraethylthiuram disulfide;Tetraetil;Thiuram E;Thiuranide;TTD;Antabus;N,N,N′,N′-Tetraethylthiuram disulfide;Tetraethylthiram disulfide;Tetraethylthiuram;Teturam;Ekagom TEDS;Ekagom TETDS;Dicupral;Averzan;Abstinil;Antetan;Antetil;Krotenal;Tetradin;Espenal;Antivitium;TTs;Hoca;Tetraethylthioperoxydicarbonic diamide;Anticol;Nocceler TET;Tetraethylthiuram sulfide;Accel TET;Ekagom DTET;Ethyl Tuads;Sanceler TET;Teturamin;Sanceler TET-G;NSC 25953;Soxinol TET;Accel TET-R;Nocceler TET-G;Exhoran;Akrochem TETD;Nocceler TED;Tetraethyldithiuram disulfide;Etiltox;N,N,N′,N′-Tetraethyldithiuram disulfide;Curekind TETD;Accelerator TET;N,N-Diethyl[(diethylcarbamothioyl)disulfanyl]carbothioamide;TETDS;Rhenogran TETD;TETD 80;Curebead PB 75;155-01-1;11078-22-1
Categories:
Active Pharmaceutical Ingredients > Specialty Drugs

Description

Disulfiram is a specific inhibitor of?aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol.

Tetraethylthiuram disulfide Basic Attributes

Molecular Weight：

296.54

Exact Mass：

296.54

BRN：

1712560

EC Number：

202-607-8

HScode：

29303000

Characteristics

PSA：

121

XLogP3：

3.9

Appearance：

Light yellow Crystals, Crystalline Powder or Granules

Density：

1.30 g/cm³

Melting Point：

71.5 °C

Boiling Point：

117 °C @ Press: 17 Torr

Flash Point：

117°C/17mm

Refractive Index：

1.620

Water Solubility：

H2O: 0.02 g/100 mL

Storage Conditions：

Store at +4°C

Vapor Pressure：

0 mmHg

Toxicity：

LD50 orally in rats: 8.6 g/kg (Child, Cramp)

Flammability characteristics：

Noncombustible Solid

Odor：

Slight odor.

Taste：

SLIGHTLY BITTER TASTE

Safety Information

Packing level：

Ⅲ

Hazard category：

Transport codes：

UN 3077 9/PG 3

wgk germany：

hazard class code：

22-43-48/22-50/53

safety instructions：

24-37-60-61

RTECS Number：

JO1225000

Marks：

Xn,N

Storage features：

Separated from strong oxidants.

Stability/Shelf Life：

Stable. Incompatible with strong oxidants.

Precautionary statement(s)：

P273-P280-P501

Hazard Statements：

H302-H317-H373-H410

Tetraethylthiuram disulfide Use and Manufacturing

Disulfiram is a copper and zinc chelator and an irreversible inhibitor of aldehyde dehydrogenase (IC50 = 0.1 mM) that has been indicated for the treatment of alcohol dependence. It also inhibits the copper-dependent enzyme dopamine β-hydroxylase, which prevents the breakdown of dopamine and has been considered as a treatment for cocaine dependence. When in complex with copper, disulfiram has been shown to inhibit purified 20S proteasome (IC50 = 7.5 μM) and 26S proteasome (IC50 = 20 μM) from MDA-MB-0231 breast cancer cells. Because disulfiram targets the ubiquitin-proteasome pathway, it has been investigated as an anti-cancer agent. Furthermore, at 250 nM it has been shown to induce reactive oxygen species, to activate JNK and p38 pathways, and to inhibit NF-κB activity, which suppresses self-renewal in cancer stem cells.

Computed Properties

Molecular Weight:296.5
XLogP3:3.9
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:296.05093334
Monoisotopic Mass:296.05093334
Topological Polar Surface Area:121
Heavy Atom Count:16
Complexity:201
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Latest News on Tetraethylthiuram disulfide

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Guide of Tetraethylthiuram disulfide

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
Latest News
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Tetraethylthiuram disulfide

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