Tetraethylthiuram disulfide
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Tetraethylthiuram disulfide
structure -
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CAS No:
97-77-8
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Formula:
C10H20N2S4
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Chemical Name:
Tetraethylthiuram disulfide
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Synonyms:
Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2),N,N,N′,N′-tetraethyl-;Disulfide,bis(diethylthiocarbamoyl);Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2),tetraethyl-;N,N,N′,N′-Tetraethylthioperoxydicarbonic diamide ([(H2N)C(S)]2S2);Abstensil;Abstinyl;Alcophobin;Antabuse;Antadix;Antaethyl;Antalcol;Antietanol;Antietil;Antikol;Aversan;Bis(N,N-diethylthiocarbamoyl) disulfide;Bis(diethylthiocarbamoyl) disulfide;Contralin;Cronetal;Disulfiram;Esperal;Etabus;Ethyl Thiram;Ethyl Thiurad;Ethyl Tuex;Exhorran;Noxal;Refusal;Stopetyl;TETD;Tetradine;Tetraethylthiuram disulfide;Tetraetil;Thiuram E;Thiuranide;TTD;Antabus;N,N,N′,N′-Tetraethylthiuram disulfide;Tetraethylthiram disulfide;Tetraethylthiuram;Teturam;Ekagom TEDS;Ekagom TETDS;Dicupral;Averzan;Abstinil;Antetan;Antetil;Krotenal;Tetradin;Espenal;Antivitium;TTs;Hoca;Tetraethylthioperoxydicarbonic diamide;Anticol;Nocceler TET;Tetraethylthiuram sulfide;Accel TET;Ekagom DTET;Ethyl Tuads;Sanceler TET;Teturamin;Sanceler TET-G;NSC 25953;Soxinol TET;Accel TET-R;Nocceler TET-G;Exhoran;Akrochem TETD;Nocceler TED;Tetraethyldithiuram disulfide;Etiltox;N,N,N′,N′-Tetraethyldithiuram disulfide;Curekind TETD;Accelerator TET;N,N-Diethyl[(diethylcarbamothioyl)disulfanyl]carbothioamide;TETDS;Rhenogran TETD;TETD 80;Curebead PB 75;155-01-1;11078-22-1
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CAS No:
Description
Disulfiram is a specific inhibitor of?aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol.
Characteristics
121
3.9
Light yellow Crystals, Crystalline Powder or Granules
1.30 g/cm3
71.5 °C
117 °C @ Press: 17 Torr
117°C/17mm
1.620
H2O: 0.02 g/100 mL
Store at +4°C
0 mmHg
LD50 orally in rats: 8.6 g/kg (Child, Cramp)
Noncombustible Solid
Slight odor.
SLIGHTLY BITTER TASTE
Safety Information
Ⅲ
9
UN 3077 9/PG 3
3
22-43-48/22-50/53
24-37-60-61
JO1225000
Xn,N
Separated from strong oxidants.
Stable. Incompatible with strong oxidants.
P273-P280-P501
H302-H317-H373-H410
Tetraethylthiuram disulfide Use and Manufacturing
Disulfiram is a copper and zinc chelator and an irreversible inhibitor of aldehyde dehydrogenase (IC50 = 0.1 mM) that has been indicated for the treatment of alcohol dependence. It also inhibits the copper-dependent enzyme dopamine β-hydroxylase, which prevents the breakdown of dopamine and has been considered as a treatment for cocaine dependence. When in complex with copper, disulfiram has been shown to inhibit purified 20S proteasome (IC50 = 7.5 μM) and 26S proteasome (IC50 = 20 μM) from MDA-MB-0231 breast cancer cells. Because disulfiram targets the ubiquitin-proteasome pathway, it has been investigated as an anti-cancer agent. Furthermore, at 250 nM it has been shown to induce reactive oxygen species, to activate JNK and p38 pathways, and to inhibit NF-κB activity, which suppresses self-renewal in cancer stem cells.
Computed Properties
Molecular Weight:296.5
XLogP3:3.9
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:296.05093334
Monoisotopic Mass:296.05093334
Topological Polar Surface Area:121
Heavy Atom Count:16
Complexity:201
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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