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Triacylglycerol lipase

Triacylglycerol lipase structure

CAS No:
9001-62-1
Chemical Name:
Triacylglycerol lipase
Synonyms:
Triacylglycerol lipase;Lipase,triacylglycerol;Lipase;Butyrinase;Glycerol ester hydrolase;Tributyrinase;Triglyceride lipase;Tween hydrolase;Steapsin;Tributyrase;Acid lipase;Lipase A;Lipase 250;E.C. 3.1.1.3;Triacetinase II;Triacetinase I;Triacetinase;Tributyrin esterase;Tweenase;Remzyme PL 600;Amano N-AP;Takedo 1969-4-9;Meito MY 30;Tween esterase;Alkaline lipase;Lipase M;GA 56 (enzyme);Triglyceride hydrolase;Triacylglycerol hydrolase;Triolein hydrolase;Lipazin;Tween-hydrolyzing esterase;Capalase L;Cacordase;Triglyceridase;Triacylglycerol ester hydrolase;Amano P;Amano CE;Amano AP;Amano B;Amano CES;Meito Sangyo OF lipase;Hepatic lipase;Hepatic triacylglycerol lipase;Lipase PL 679;Lipase SAM-II;Lipase M-AP 10;Lipase PL;Lipase PN;Lipolase;Lipozyme;Amano M;Lipase OF;Lipase AP;Lipase P;Lipase CE;Lipolase 30T;Arthrobacter lipase;Lipase-esterase;Postheparin plasma hepatic lipase;Lipase N;Randozyme SP 382;Lipase PS;Triacylglyceride lipase;Lipolase SP 400;Saiken 100;Olipase 4S;Lipase MY;SP 398;C-Lipase;Amano LPL 200S;Palatase M 1000L;Lipase LP;Lipase AY;Lipolase 100T;Palatase;Trioleinase;Lipozyme IM 60;Pregastric esterase;Lipase D;Lipolase 100L;Palatase A 750L;Capalase K;Italase C;Piccantase A;Lipomax CXT;Lipolactine G 10x;GA 56;Lipase AY Amano;Toyozyme LIP;Lipomax;Lipase AY 30;Lumafast;Lipase QL;Lipase AK;Lipomax CXT 1000;CloneZyme ESL 001;Lipozyme IM;Lipolase Ultra;Lipolase EX;9001-70-1;9004-01-7;9014-49-7;114558-43-9;114558-45-1;119663-46-6;132823-04-2;135105-44-1;142615-72-3;211049-96-6;211049-97-7;211255-77-5;212955-16-3;2243810-62-8
Categories:
Food Additives > Enzyme

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Description

powder

Triacylglycerol lipase Basic Attributes

Molecular Weight：

238.202

Exact Mass：

231.988754

EC Number：

232-619-9

NSC Number：

87878

DSSTox ID：

DTXSID0047458

HScode：

35079020

Characteristics

PSA：

74.6

XLogP3：

4.88

Appearance：

yellow-brown; solution

Density：

1.4±0.1 g/cm3

Boiling Point：

309.8±11.0 °C at 760 mmHg

Flash Point：

141.8±13.7 °C

Refractive Index：

1.601

Water Solubility：

It is soluble in water

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

20/21/22

safety instructions：

22-24/25-36/37-36

RTECS Number：

TO9776500

Marks：

B,Xn

Stability/Shelf Life：

Moisture sensitive. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

P261, P285, P304+P341, P342+P311, P501

Hazard Statements：

H334

GHS Classification：

|Danger|H334 (99.94%): May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory]|P261, P285, P304+P341, P342+P311, and P501|Aggregated GHS information provided by 1745 companies from 9 notifications to the ECHA C&L Inventory.

Triacylglycerol lipase Use and Manufacturing

Uses

To split fats without damaging sensitive constituents, such as vitamins or unsaturated fatty acids. In food processing for flavor improvement; in detergents for the improvement of cleaning action. For review of industrial applications of microbial lipases, see Seitz, J. Am. Oil Chem. Soc. 51, 12 (1974). Trans fatty acids (TFAs) are fatty acids with at least one double bond in (E)- configuration. The consumption of TFAs increases the risk of coronary heart diseases. Thus, their concentrations in lipid-containing products should be reduced [87]. Naturally, TFAs occur in small amounts in meat and milk of ruminants, but the most significant concentrations of TFAs develop during partial hydrogenation and deodorization of fats [88]. The formation of TFAs during fat hardening can be avoided by lipase catalyzed transesterification to increase the slip melting points of fats.
For enzymatic transesterification between different lipids, triacylglycerol lipases (triacylglycerol acylhydrolase, EC 3.1.1.3) acting on the SN1 and SN3 positions of the triglyceride are used. Various lipases have been applied for the production of table margarine out of fat-oil blends. Lipases of the ascomycetes Thermomyces lanuginosa and Rhizomucor miehei, as well as a lipase of the proteobacterium Pseudomonas sp., were used for transesterification of fat blends consisting of palm stearin and vegetable oil. Fully hydrogenated oils in blends with vegetable oils also have been used. In all studies, an increase of the slip melting points and the solid fat content was achieved in the fat-oil blend, thus indicating an alternative method for fat hardening via hydrogenation.

Manufacturing Info：

Triacylglycerol lipase: ACTIVE|XU - indicates a substance exempt from reporting under the Chemical Data Reporting Rule, (40 CFR 711).

Use Classification：

EPA Safer Chemical Functional Use Classes -> Enzymes and Enzyme Stabilizers|Safer Chemical Classes -> Yellow triangle - The chemical has met Safer Choice Criteria for its functional ingredient-class, but has some hazard profile issues|Food Additives -> ENZYME_PREPARATION; -> JECFA Functional Classes

Food Additive Classes：

Food Additives -> ENZYME_PREPARATION;

Computed Properties

Molecular Weight:238.20
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:238.05924582
Monoisotopic Mass:238.05924582
Topological Polar Surface Area:78.1
Heavy Atom Count:17
Formal Charge:1
Complexity:247
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Material

Ammonium sulfate

Drug Function and Efficacy

Can break down fat into glycerol and fatty acids

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Pancreatin enteric-coated capsules
Ingredients	Ingredients: Each capsule contains 150 mg of pancreatin (equivalent to 10,000 European Pharmacopoeia units of lipase, 8,000 European Pharmacopoeia units of amylase, and 600 European Pharmacopoeia units of protease.
Indication	1This product should not be taken with acidic drugs. 2This product can be taken with an equal amount of sodium bicarbonate to increase the efficacy. 3If used with other drugs at the same time, drug interactions may occur. Please consult a doctor or pharmacist for details.
Specifications	0.15 g
Manufacturer	Chongqing Yangyang Jiachen Pharmaceutical Co., Ltd.

Pancreatin enteric-coated tablets
Ingredients	This product is a mixture of various enzymes obtained from the pancreases of healthy pigs, cattle, sheep and other animals. Each gram of pancreatic enzyme powder can convert 25 grams of casein.
Indication	1This product should not be taken with acidic drugs. 2This product can be taken with an equal amount of sodium bicarbonate to increase the efficacy. 3If used with other drugs at the same time, drug interactions may occur. Please consult a doctor or pharmacist for details.
Specifications	0.3g

Pancreatin enteric-coated tablets
Ingredients	This product is a mixture of various enzymes obtained from the pancreases of healthy pigs, cattle, sheep and other animals. Each gram of pancreatic enzyme powder can convert 25 grams of casein.
Indication	1This product should not be taken with acidic drugs. 2This product can be taken with an equal amount of sodium bicarbonate to increase the efficacy. 3If used with other drugs at the same time, drug interactions may occur. Please consult a doctor or pharmacist for details.
Specifications	0.3g

See More Related Drugs

Registered Holders

Nordmark Pharma GmbH

Germany
Active
Southwest Pharmaceutical Co., Ltd.

China
Active
WALLERSTEIN

United States
Inactive

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