Trypsin

372.1

725.338

232-650-8

DTXSID9040922

YELLOW TO GRAYISH-YELLOW POWDER OR CRYSTALS|WHITE TO YELLOWISH WHITE CRYSTALLINE OR AMORPHOUS POWDER

35079090

274

lyophilized powder

115 °C

soluble in water (10 mg/ml), phosphate buffers (10 mg/ml), and balanced salt solutions (1 mg/ml).Reconstitute in aqueous buffer

−20°C

ODORLESS

ACTS OPTIMALLY @ PH VALUES BETWEEN 7 & 9

NONH for all modes of transport

2

36/37/38-42-42/43

22-24-26-36/37-45-23

GC3050000

Xn,B

Stable. Incompatible with strong oxidizing agents.

P261-P305 + P351 + P338-P342 + P311

H315-H319-H334-H335

|Danger|H315: Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P285, P302+P352, P304+P340, P304+P341, P305+P351+P338, P312, P321, P332+P313, P337+P313, P342+P311, P362, P403+P233, P405, and P501|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P273, P280, P285, P302+P352, P304+P340, P304+P341, P305+P351+P338, P312, P321, P332+P313, P337+P313, P342+P311, P362, P391, P403+P233, P405, and P501|Aggregated GHS information provided by 269 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|P261, P264, P272, P280, P285, P302+P352, P304+P341, P305+P351+P338, P321, P332+P313, P333+P313, P337+P313, P342+P311, P362, P363, and P501

TRYPSIN IS EFFECTIVE WHEN ADMIN AS AEROSOL FOR LIQUEFACTION OF VISCID SPUTUM. IT IS POSSIBLY EFFECTIVE FOR TOPICAL APPLICATION IN DEBRIDEMENT OF OPEN WOUNDS & ULCERS & FOR INTRAPLEURAL USE IN POSTOPERATIVE OR TRAUMATIC HEMOTHORAX OR EMPYEMA.|IT IS...USEFUL FOR LIQUEFACTION OF COAGULATED BLOOD & EXUDATES THAT HAVE NOT BECOME ORGANIZED BY FIBROUS TISSUE.|TRYPSIN DIFFERS FROM STREPTOKINASE-STREPTODORNASE IN 3 WAYS: IT DOES NOT REQUIRE COFACTOR, IT IS EFFECTIVE AGAINST GREATER NUMBER OF PROTEINS, & IT IS CAPABLE OF HYDROLYZING PROTEIN MOIETY OF RESP TRACT MUCINS.|VET: IN DEBRIDEMENT OR REMOVAL OF NECROTIC TISSUES. EFFECTIVE IN: OSTEOMYELITIS, SURFACE ULCERS, SOFT TISSUE ABSCESSES, BOVINE FOOT ROT, PARANASAL SINUSITIS, SUPPURATIVE BURSITIS (FISTULOUS WITHERS), SUPPURATIVE ARTHRITIS, EQUINE FOOT CANKER, PURULENT & GANGRENOUS MASTITIS, PYOMETRA, METRITIS, SUPPURATIVE OTITIS...|For more Therapeutic Uses (Complete) data for TRYPSIN (7 total), please visit the HSDB record page.

TRYPSIN IS CONTRAINDICATED IN PT WITH HEPATIC DYSFUNCTION. IT SHOULD NEVER BE ADMIN IV. ... IT SHOULD BE USED WITH CAUTION IN EMPYEMA & BRONCHOPLEURAL FISTULAS OF TUBERCULOUS ORIGIN. ITS IRRITATING EFFECT ON RESP MUCOSA LIMITS ITS USEFULNESS AS MUCOLYTIC AGENT.|...TRYPSIN SHOULD NOT BE USED TOPICALLY IN TREATMENT OF CORNEAL INJURIES.

NEITHER ORAL NOR IM ADMIN...RESULTS IN SIGNIFICANT BLOOD LEVELS.

IT ACTS DIRECTLY TO HYDROLYZE NATURALLY OCCURRING PROTEINS... IT HYDROLYZES ONLY ESTER OR PEPTIDE BONDS IN WHICH CARBOXYL MOIETY OF AMINO ACID IS LYSINE OR ARGININE...

TOPICAL APPLICATION OF TRYPSIN MAY PRODUCE SEVERE BURNING SENSATION...LOCAL INFILTRATION INTO CLOSED CAVITIES MAY CAUSE SLIGHT INCR IN BODY TEMP & HEART RATE. ... AEROSOL INHALATION MAY CAUSE IRRITATION OF EYES & NOSE, GLOSSITIS, PHARYNGITIS, HOARSENESS, & SYSTEMIC REACTIONS.|ANAPHYLACTIC SHOCK MAY OCCUR IN PT PREVIOUSLY TREATED WITH TRYPSIN.|TRYPSIN FREQUENTLY PRODUCES SEVERE BURNING SENSATION @ SITE OF INJECTION.|RAPID DESTRUCTION OF CORNEA & LOSS OF EYE HAS BEEN REPORTED AFTER SUBCONJUNCTIVAL ADMIN OF TRYPSIN IN 2 CASES OF SEVERE BURNS OF EYE...

alpha Tryptase

EACH MILLIGRAM CONTAINS NOT LESS THAN 2500 NF TRYPSIN UNITS. IT IS MARKETED AS POWDER & AS TRYPSIN CRYSTALLIZED FOR AEROSOL, NF, 250,000 NF UNITS/ML. IT IS ALSO AVAILABLE IN COMBINATION WITH CHYMOTRYPSIN AS TABLET.

Trypsin: ACTIVE|XU - indicates a substance exempt from reporting under the Chemical Data Reporting Rule, (40 CFR 711).|OCCURRENCE: PROTEOLYTIC ENZYME FORMED IN SMALL INTESTINE BY ACTION OF PEPTIDASE, ENTEROKINASE, ON PANCREATIC CELL PRODUCT, TRYPSINOGEN.|POTENCY: NOT LESS THAN 2500 NF UNITS/MG.|OCCURRENCE: .../FOUND/ IN BEER YEAST, MOLDS & BACTERIA.

HEMOGLOBIN IS DENATURED WITH ALKALINE UREA SOLN. TRYPSIN HYDROLYSES COMPD FROM DENATURED PROTEIN WHICH ARE SOL IN TRICHLOROACETIC ACID & WHOSE TYROSINE & TRYPTOPHAN CONTENT CAN BE DETERMINED BY...SPECTROPHOTOMETRY.|MEASUREMENT WITH CASEIN AS SUBSTRATE. ...DURING HYDROLYSIS OF CASEIN BY TRYPSIN, PRODUCTS SOL IN TRICHLOROACETIC ACID ARE FORMED, & TYROSINE & TRYPTOPHAN CONTENT OF THESE IS DETERMINED BY MEASUREMENT /BY SPECTROPHOTOMETRY/ OF EXTINCTION AT 280 NM.

Food Additives -> ENZYME_PREPARATION; -> JECFA Functional Classes

Food Additives -> ENZYME_PREPARATION;