Follicle stimulating hormone

Solid; soluble in water.

Gonal-F was launched in Austria, Germany, Denmark, Ireland, Italy, Norway, Sweden, Switzerland, France and the UK for the treatment of infertility. The recombinant follicule stimulating hormone (recFSH) was produced by introducing the genes for the α- and β-FSH subunits into the genome of Chinese hamster ovary cells. The isolated recFSH was a glycosylated bioactive dimer that appeared to be identical to urinary human FSH. Biochemically, the recFSH was equal to or slightly better to the uroFSH. The ultra-high purity of recFSH makes it less prone to side effects from contaminants in uroFSH and can be injectable.

A gonadotropic glycoprotein secreted by the anterior pituitary gland. It regulates the metabolic activity of the granulosa of the mammalian ovary; stimulates maturation of ovarian follicles, and production of estrogens. Spermatogenesis is partially under

FSH is purified by Sephadex G100 gel filtration followed by carboxymethyl-cellulose with NH4OAc pH 5.5. The latter separates luteinising hormone from FSH. Its solubility in H2O is 0.5%. It has an isoelectric point of 4.5. A solution of 1mg in saline (100mL) can be kept at 60o for 0.5hour. Activity is retained in a solution at pH 7-8 for 0.5hour at 75o. The activity of a 50% aqueous EtOH solution is destroyed at 60o in 15minutes. [Bloomfield et al. Biochim Biophys Acta 533 371 1978, Hartree Biochem J 100 754 1966, Pierce & Parsons Ann Rev Biochem 50 465 1981.]

FSH Porcine is a glycoprotein produced from pituitaries of porcine. The FSH is purified by proprietary chromatographic techniques.

A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consi

Follicle stimulating hormone (FSH) from human pituitary has been used for-in vitroluteinization of Macaque granulosa cellsluteal cell proliferation assayculturing of preantral follicle cells obtained from micein vitromaturation of immature cumulus-oocyte complexes (COCs) obtained from mice andculture of RAW264.7 cell line

Recombinant human FSH is used for the treatment of infertility and to stimulate follicular development. Recently, it has been well known that the majority of gonadotroph adenomas are clinically silent/nonfunctioning and difficult to identify. They are poorly differentiated and produce and secrete hormones inefficiently. These hormones include FSH β-, LH β-, and GPH α-subunits.