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Triamcinolone diacetate

Triamcinolone diacetate structure

CAS No:
67-78-7
Formula:
C25H31FO8
Chemical Name:
Triamcinolone diacetate
Synonyms:
Pregna-1,4-diene-3,20-dione,16,21-bis(acetyloxy)-9-fluoro-11,17-dihydroxy-,(11β,16α)-;Pregna-1,4-diene-3,20-dione,9-fluoro-11β,16α,17,21-tetrahydroxy-,16,21-diacetate;(11β,16α)-16,21-Bis(acetyloxy)-9-fluoro-11,17-dihydroxypregna-1,4-diene-3,20-dione;Aristocort diacetate forte;Aristocort diacetate parenteral;Aristocort Forte;16α,21-Diacetoxy-9α-fluoro-11β,17α-dihydroxy-1,4-pregnadiene-3,20-dione;Δ1-9α-Fluoro-16α-hydroxyhydrocortisone diacetate;9α-Fluoro-16α-hydroxyprednisolone 16,21-diacetate;9α-Fluoro-1,4-pregnadiene-11β,16α,17α,21-tetraol-3,20-dione 16,21-diacetate;9-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 16,21-diacetate;Δ1-16α-Hydroxy-9α-fluorohydrocortisone diacetate;16α-Hydroxy-9α-fluoroprednisolone diacetate;Kenacourt;Orion;Triamcinolone diacetate;Triamcinolone 16,21-diacetate;Aristocort Parenterals;Polcortolon;8357RP;Tedarol;Triamolone 40;Aristocort Forte Parenteral;Aristocort Syrup;Tracilon;Cenacort;TAC-D;Kenacort diacetate Syrup;CINO 40
Categories:
Analytical Chemistry > Standard

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Description

White Solid

Triamcinolone diacetate is a corticosteroid hormone.

Triamcinolone diacetate Basic Attributes

Molecular Weight：

478.51

Exact Mass：

478.51

EC Number：

200-669-0

UNII：

A73MM2Q32P

DSSTox ID：

DTXSID0048713

HScode：

29349990

Characteristics

PSA：

127.20000

XLogP3：

2.16

Density：

1.4±0.1 g/cm3

Melting Point：

235 °C

Boiling Point：

608.5±55.0 °C at 760 mmHg

Flash Point：

321.8±31.5 °C

Refractive Index：

1.573

Water Solubility：

48mg/L(25 ºC)

Flammability characteristics：

Flammable; burning produces toxic fluoride fumes

Specific rotation：

D25 +22° (chloroform)

Collision Cross Section：

209.5 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Packing level：

III

Hazard category：

Transport codes：

UN 3272 3/PG 3

wgk germany：

hazard class code：

R10:Flammable.

safety instructions：

S26-S36/37/39-S45

Storage features：

Warehouse ventilated, low temperature and dry

Precautionary statement(s)：

P201, P202, P261, P264, P270, P271, P280, P281, P301+P310, P301+P312, P302+P352, P304+P312, P304+P340, P308+P313, P312, P321, P322, P330, P363, P405, P501

Hazard Statements：

H301

GHS Classification：

|Danger|H301 (25%): Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P261, P264, P270, P271, P280, P281, P301+P310, P301+P312, P302+P352, P304+P312, P304+P340, P308+P313, P312, P321, P322, P330, P363, P405, and P501|Aggregated GHS information provided by 4 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)

MeSH Entry Terms：

Polcartolone

Triamcinolone diacetate Use and Manufacturing

Uses

antiinflammatory

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Pharmaceuticals

Computed Properties

Molecular Weight:478.5
XLogP3:1.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:6
Exact Mass:478.20029610
Monoisotopic Mass:478.20029610
Topological Polar Surface Area:127
Heavy Atom Count:34
Complexity:1020
Defined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes