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Penicillin G sodium

Penicillin G sodium structure

CAS No:
69-57-8
Formula:
C16H18N2O4S.Na
Chemical Name:
Penicillin G sodium
Synonyms:
4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]- (2S,5R,6R)-,sodium salt (1:1);4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-,monosodium salt;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-[2S-(2α,5α,6β)]-,monosodium salt;4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid,3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- (2S,5R,6R)-,monosodium salt;Benzylpenicillinic acid sodium salt;Benzylpenicillin sodium;Benzylpenicillin sodium salt;Novocillin;Penicillin G sodium;Penilaryn;Sodium benzylpenicillin;Sodium benzylpenicillinate;Sodium penicillin G;Sodium penicillin II;Veticillin;Penicillin G sodium salt;Sodium benzylpenicillin G;Pen-A-Brasive;Sodium penicillin;Sodium 6-(phenylacetamido)penicillanate;Mycofarm;Crystapen;Monosodium benzylpenicillin;Monocillin;American penicillin;Nalpen G;Nobak;Ethacillin;1406-09-3;8049-60-3;878003-24-8
Categories:
Active Pharmaceutical Ingredients > Antibiotics

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Description

Penicillin G sodium salt is a typical β-lactam antibiotic.

Penicillin G sodium Basic Attributes

Molecular Weight：

356.37

Exact Mass：

356.080658

EC Number：

200-710-2

HScode：

29411000

Characteristics

PSA：

115

XLogP3：

-0.14510

Appearance：

colorless or white powder

Density：

1.41 (NTP, 1992)

Melting Point：

222 °C (decomp)

Boiling Point：

663.3°C at 760 mmHg

Refractive Index：

300 ° (C=2, H2O)

Water Solubility：

H2O: 100 mg/mL Solutions should be filter sterilized and stored at 2-8°C for 1 week or at -20°C for extended periods. Solutions are stable at 37°C for 3 days.

Storage Conditions：

2-8°C

Toxicity：

LD50 oral in rat: 6916mg/kg

Specific rotation：

D24.8 +301° (c = 2.0 in water)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

42/43

safety instructions：

22-36/37-45

RTECS Number：

XH9800000

Marks：

Xn,Xi

Stability/Shelf Life：

Stability Stable, but incompatible with a wide variety of materials, including acids, oxidizing agents, heavy metals, alcohols, glycerol, thiomersal, many surface-active agents, alkalies, peroxides, reducing agents, lanolin, glycol, sugars, amines, iodine, iodides, thiols. Hygroscopic.

Precautionary statement(s)：

P261-P280-P284-P304 + P340-P342 + P311

Hazard Statements：

H317-H334

Penicillin G sodium Use and Manufacturing

Methods of Manufacturing

A hybrid strain of Penicilum chryso-genum is used, and the naturally isolated yellow spore species are prepared by microbial fermentation.

Uses

Sodium salt of Penicillin G, an antibacterial, antimicrobial medication. Used in the treatment of pneumococcus and streptococcus bacterial infections.

Material

Butyl acetate

Sodium hydroxide

Ethyl acetate

SODIUM SULFATE

Glucose

Sodium acetate trihydrate

Ethanol

1-Butanol

Sodium sulfate

Ammonium sulfate

Price Analysis

Make your Penicillin G sodium purchase based on the price and market insights! ECHEMI provides professional market insights with prices for you to make a better choice. Learn more on Penicillin G sodium prices .

Drug Function and Efficacy

Penicillin has good antibacterial effect on Streptococcus such as hemolytic Streptococcus, Streptococcus pneumoniae and Staphylococcus that does not produce penicillinase. It has moderate antibacterial effect on enterococci, and Neisseria gonorrhoeae, Neisseria meningitidis, Corynebacterium diphtheriae, Bacillus anthracis, Actinomyces bovis, Streptobacillus candida, Listeria monocytogenes, Leptospira and Treponema pallidum are sensitive to this product. This product also has certain antibacterial activity against Haemophilus influenzae and Bordetella pertussis, and other Gram-negative aerobic or facultative anaerobic bacteria are less sensitive to this product. This product has good antibacterial effect on Clostridium, Peptostreptococcus anaerobic bacteria and melanin-producing Bacteroides, but has poor antibacterial effect on Bacteroides fragilis. Penicillin exerts its bactericidal effect by inhibiting bacterial cell wall synthesis.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Penicillin Sodium for Injection
Ingredients	The main ingredient of this product is penicillin sodium, and its chemical name is (2S,5R,6R)-3,3-dimethyl-6-(2-phenylacetylamino)7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt.
Indication	1 Chloramphenicol, erythromycin, tetracyclines, and sulfonamides can interfere with the activity of this product, so they should not be dripped from the same bottle. 2 Probenecid, aspirin, indomethacin, phenylbutazone, and sulfonamides reduce the renal tubular secretion of penicillin and prolong the serum half-life of this product. Penicillin can enhance the anticoagulant effect of warfarin. 3 This product is incompatible with heavy metals, especially copper, zinc, and mercury. 4 Turbidity will appear after adding cephalothin, lincomycin, tetracycline, vancomycin, erythromycin ethylsuccinate, amphotericin B, norepinephrine, metaraminol, phenytoin sodium, hydroxyzine hydrochloride, prochlorperazine, promethazine, vitamin B group, vitamin C group, etc. to penicillin intravenous infusion. 5nbs
Specifications	0.6g (1 million units)
Manufacturer	ZHONGFU Pharmaceutical Co., Ltd.

Penicillin Sodium for Injection
Ingredients	The main ingredient of this product is penicillin sodium, and its chemical name is (2S,5R,6R)-3,3-dimethyl-6-(2-phenylacetylamino)7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt.
Indication	1 Chloramphenicol, erythromycin, tetracyclines, and sulfonamides can interfere with the activity of this product, so they should not be dripped from the same bottle. 2 Probenecid, aspirin, indomethacin, phenylbutazone, and sulfonamides reduce the renal tubular secretion of penicillin and prolong the serum half-life of this product. Penicillin can enhance the anticoagulant effect of warfarin. 3 This product is incompatible with heavy metals, especially copper, zinc, and mercury. 4 Turbidity will appear after adding cephalothin, lincomycin, tetracycline, vancomycin, erythromycin ethylsuccinate, amphotericin B, norepinephrine, metaraminol, phenytoin sodium, hydroxyzine hydrochloride, prochlorperazine, promethazine, vitamin B group, vitamin C group, etc. to penicillin intravenous infusion. 5nbs
Specifications	Calculated as C16H17N2NaO4S 0.48g (800,000 units)

Penicillin Sodium for Injection
Ingredients	The main ingredient of this product is penicillin sodium, and its chemical name is (2S,5R,6R)-3,3-dimethyl-6-(2-phenylacetylamino)7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt.
Indication	1 Chloramphenicol, erythromycin, tetracyclines, and sulfonamides can interfere with the activity of this product, so they should not be dripped from the same bottle. 2 Probenecid, aspirin, indomethacin, phenylbutazone, and sulfonamides reduce the renal tubular secretion of penicillin and prolong the serum half-life of this product. Penicillin can enhance the anticoagulant effect of warfarin. 3 This product is incompatible with heavy metals, especially copper, zinc, and mercury. 4 Turbidity will appear after adding cephalothin, lincomycin, tetracycline, vancomycin, erythromycin ethylsuccinate, amphotericin B, norepinephrine, metaraminol, phenytoin sodium, hydroxyzine hydrochloride, prochlorperazine, promethazine, vitamin B group, vitamin C group, etc. to penicillin intravenous infusion. 5nbs
Specifications	0.24g (400,000 units)

See More Related Drugs

Registered Holders

Fersinsa Gb S.A. de C.V.

Japan
Active
INNER MONGOLIA CHANGSHENG PHARMACEUTICAL CO. LTD.

Brazil
Active
Reyoung Pharmaceutical Co., Ltd.

China
Active

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