2',3'-DIDEOXY-3'-FLUORO-GUANOSINE
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2',3'-DIDEOXY-3'-FLUORO-GUANOSINE
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CAS No:
92562-88-4
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Formula:
C10H12FN5O3
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Chemical Name:
2',3'-DIDEOXY-3'-FLUORO-GUANOSINE
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Synonyms:
MIV 210;Lagociclovir;3'-fluoro-2',3'-dideoxyguanosine;2',3'-DIDEOXY-3'-FLUORO-GUANOSINE;Guanosine, 2',3'-dideoxy-3'-fluoro-
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CAS No:
Description
Lagociclovir(MIV-210) is a prodrug of 3'-fluoro-2',3'-dideoxyguanosine with high oral bioavailability in humans and potent activity against HBV. IC50 value:Target: Anti-HBV compoundOral administration of MIV-210 at 20 or 60 mg/kg of body weight/day induced a rapid virological response in chronically infected woodchucks, reducing serum WHV DNA levels by 4.75 log10 and 5.72 log10, respectively, in 2 weeks. Further, a daily dose of 10 mg/kg decreased the serum WHV load 400-fold after 4 week
2',3'-DIDEOXY-3'-FLUORO-GUANOSINE
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