Glimepiride

Glimepiride.

Based on the experience of using glimepiride tablets and other sulfonylurea drugs, attention should be paid to the following drug interactions: 1. Taking one of the following drugs that potentially cause a decrease in blood sugar may cause hypoglycemia in some cases, such as: phenylbutazone, azapropazone, oxybutazone, insulin and oral hypoglycemic drugs, metformin, salicylic acid, para-aminosalicylic acid, steroids and androgens, chloramphenicol, coumarin anticoagulants, fenfluramine, clofibrate, ACE inhibitors, fluoxetine, allopurinol, etc. 2. Taking one of the following drugs that weaken the hypoglycemic effect may increase blood sugar levels, such as: estrogen and progesterone, thiazide diuretics, thyroid-stimulating hormone, glucocorticoids, phenothiazines and their derivatives, chlorpromazine, epinephrine and other sympathomimetic drugs, niacin (high doses) and

The main ingredient of this product is glimepiride.

1. If glimepiride tablets are taken at the same time as certain other drugs, the hypoglycemic effect of glimepiride may be enhanced or weakened. Therefore, other drugs should be taken with the knowledge or guidance of a doctor. 2. Glimepiride is metabolized by cytochrome P450 (CYP2C9). Its metabolism is known to be affected by the simultaneous use of CYP2C9 agonists (rifampicin) or inhibitors (fluconazole). 3. The results of in vivo drug-drug interaction studies showed that the simultaneous use of fluconazole (one of the strongest CYP2C9 inhibitors) can increase the AUC of glimepiride by about 2 times. 4. Based on the experience of using glimepiride tablets and other sulfonylurea drugs, the following drug interactions should be noted: Taking one of the following drugs that potentially cause a decrease in blood sugar may lead to hypoglycemia in some cases, such as: phenylbutazone, azapropazone, oxybutazone, insulin and oral hypoglycemic drugs, metformin, salicylic acid, para-aminosalicylic acid, steroids and androgens, chloramphenicol, coumarin anticoagulants, fenfluramine, clofibrate, ACE inhibitors, fluoxetine, allopurinol, sympathetic nerve drugs, cyclophosphamide, ifosfamide, sulfinpyrazone, long-acting sulfonamides, tetracyclines, monoamine oxidase inhibitors, quinolone antibiotics, probenecid, miconazole, pentoxifylline (high-dose parenteral administration), tritoquine, and fluconazole. Taking one of the following drugs that weaken the hypoglycemic effect may increase blood glucose levels, such as: estrogen and progesterone, thiazide diuretics, thyroid stimulating hormone, glucocorticoids, phenothiazine and its derivatives, chlorpromazine, epinephrine and other sympathomimetics, niacin (high doses) and its derivatives, laxatives (when used for a long time), phenytoin, diazoxide, glucagon, barbiturates, rifampicin, acetazolamide. 5. H2 receptor antagonists, beta-blockers, clonidine and reserpine may enhance or weaken the hypoglycemic effect. 6. Under the influence of sympathetic drugs such as beta-blockers, clonidine, guanethidine and reserpine, the adrenergic counter-regulation signs of hypoglycemia may be weakened or even disappear. 7. Alcohol consumption may enhance or weaken the hypoglycemic effect of glimepiride tablets, but it is unpredictable. 8. Glimepiride may enhance or weaken the effect of coumarin derivatives.

The main ingredient of this product is glimepiride. Chemical name: 1-[4-[2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)-ethyl]-benzenesulfonyl]-3-(trans-4-methylcyclohexyl)-urea. Molecular weight: C24H34N4O5S

1. The effect of this product can be enhanced when used in combination with salicylates, sulfonamides, phenylbutazone, anti-tuberculosis drugs, tetracyclines, monoamine oxidase inhibitors, beta-receptor blockers, chloramphenicol, coumarins and cyclophosphamide. 2. Chlorpromazine, sympathomimetic drugs, corticosteroids, thyroid hormones, oral contraceptives and niacin preparations can reduce the hypoglycemic effect of this product. 3. This product can reduce the patient's tolerance to alcohol, and alcohol may also enhance the hypoglycemic effect of the drug.