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2-Chloroethyl methyl ether

2-Chloroethyl methyl ether structure

CAS No:
627-42-9
Formula:
C3H7ClO
Chemical Name:
2-Chloroethyl methyl ether
Synonyms:
Ethane,1-chloro-2-methoxy-;Ether,2-chloroethyl methyl;1-Chloro-2-methoxyethane;2-Chloroethyl methyl ether;2-Methoxyethyl chloride;Ethylenechlorohydrin methyl ether;2-Chloro-1-methoxyethane;R-E 280;Methyl 2-chloroethyl ether;1-Chloro-2-(methyloxy)ethane
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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Description

clear colorless to yellowish liquid

2-Chloroethyl methyl ether Basic Attributes

Molecular Weight：

94.54

Exact Mass：

94.54

EC Number：

210-999-7

UNII：

U890TJ10YM

DSSTox ID：

DTXSID6060840

HScode：

2909199090

Characteristics

PSA：

9.2

XLogP3：

0.7

Appearance：

clear, colourless to slightly yellow liquid

Density：

1.0345 g/cm³ @ Temp: 20 °C

Melting Point：

91 °C

Boiling Point：

92-93 °C

Flash Point：

15.0±0.0 °C

Refractive Index：

1.387

Water Solubility：

60 g/L (20 C)

Storage Conditions：

Flammables area

OH：

4.69e-12 cm3/molecule*sec

Safety Information

Packing level：

Ⅱ

Hazard category：

Transport codes：

3271

wgk germany：

hazard class code：

safety instructions：

S36/37-S23-S16

Marks：

F:Flammable;Xn:Harmful;

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P210-P280

Hazard Statements：

H225-H302 + H312 + H332

GHS Classification：

|Danger|H225 (86.02%): Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P261, P264, P270, P271, P280, P301+P312, P302+P352, P303+P361+P353, P304+P312, P304+P340, P311, P312, P321, P322, P330, P363, P370+P378, P403+P233, P403+P235, P405, and P501|Aggregated GHS information provided by 236 companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Water Concentrations：

EXAMINES THE EXPOSURE OF MAN TO ORGANIC COMPDS VIA DRINKING WATER.|THIS COMPOUND HAS BEEN DETECTED IN FINISHED DRINKING WATER.

2-Chloroethyl methyl ether Use and Manufacturing

Methods of Manufacturing

Calcium carbonate (27.3 g, 273.2 mmol), dimethyl sulfate (23.5 mL, 248.4 mmol), and 2-chloroethanol (16.6 mL, 248.4 mmol) were mixed together in a round bottom flask equippedwith distillation setup. The reaction mixture was heated at 120-130 °C until distillation ceased(overnight). Then the distillate was diluted with ether, washed with 2N NaOH. The aqueouslayer was extracted again with ether, then the combined ether layer was dried (MgSO4), andunderwent normal distillation (fractions collected at vapor temperature 88-90 °C) to get desiredproduct 16 as a colorless liquid. Yield: 10.2 g, 43percent.A.20 Synthesis of 1 3-di(2-methoxyethyl)benzimidazoIe chloride (20) CI l-(2-Methoxyethyl lH-benzimidazole (1.17 g, 6.66 mmol) was dissolved in dry acetonitnle (2.0 mL), into which was then added

Manufacturing Info：

Ethane, 1-chloro-2-methoxy-: ACTIVE|NEAREST CONGENER THAT HAS BEEN STUDIED IS BIS(2-CHLOROETHYL)ETHER. FURTHER GENERAL INFORMATION ON HALOETHERS IN: HUMAN HEALTH EFFECTS, HALOETHERS; USEPA, SD LEE, PHD, PROJECT MANAGER.

Computed Properties

Molecular Weight:94.54
XLogP3:0.7
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:94.0185425
Monoisotopic Mass:94.0185425
Topological Polar Surface Area:9.2
Heavy Atom Count:5
Complexity:16.4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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CAS No.: 627-42-9

Grade: Industrial Grade

Content: 99.9%

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2-Methoxyethyl chloride 627-42-9

CAS No.: 627-42-9

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Latest News on 2-Chloroethyl methyl ether

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Guide of 2-Chloroethyl methyl ether

Description
Basic Attributes
Characteristics
Safety Information
Toxicity
Use and Manufacturing
Computed Properties
Recommended Suppliers
Latest News
Learn More Other Chemicals

2-Chloroethyl methyl ether

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