Procainamide hydrochloride
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Procainamide hydrochloride
structure -
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CAS No:
614-39-1
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Formula:
C13H21N3O.ClH
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Chemical Name:
Procainamide hydrochloride
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Synonyms:
Benzamide,4-amino-N-[2-(diethylamino)ethyl]-,hydrochloride (1:1);Benzamide,p-amino-N-[2-(diethylamino)ethyl]-,monohydrochloride;Benzamide,4-amino-N-[2-(diethylamino)ethyl]-,monohydrochloride;Novocamid hydrochloride;Procainamide monohydrochloride;Procardyl;Pronestyl hydrochloride;HC 5006;Procainamide hydrochloride;Pronestyl;Amisalin;4-Amino-N-[2-(diethylamino)ethyl]benzamide monohydrochloride;Amidoprocaine;Cardiorytmin;Spicain amide;Procamid;Novocaine amide hydrochloride;Procan SR;Procamide;Procapan
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Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs
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CAS No:
Description
Procainamide hydrochloride is an anti-arrhythmic agent and is used to treat cardiac arrhythmia; induces rapid block of the batrachotoxin(BTX)-activated sodium channels of the heart muscle and acts as antagonist to long gating closures.
Procainamide Hydrochloride is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine. Procainamide hydrochloride reversibly binds to and blocks activated (open) voltage-gated sodium channels, thereby blocks the influx of sodium ions into the cell, which leads to an increase in threshold for excitation and inhibit depolarization during phase 0 of the action potential. In addition, the effective refractory period (ERP), action potential duration (APD), and ERP/APD ratios are increased, resulting in decreased impulse conduction velocity. The lasting action potential may also be due to blockage of outward K+ currents. The result is a decrease in automaticity, increase in refractory period and slowing of impulse conduction.|A class Ia antiarrhythmic drug that is structurally-related to PROCAINE.
Procainamide hydrochloride Basic Attributes
271.79
271.145142
210-381-7
SI4064O0LX
757279
DTXSID2049422
C47687
2924299090
Characteristics
58.4
3.11450
White to slightly yellow Powder
1.2027 (rough estimate)
167 °C
421.8ºCat 760 mmHg
208.9ºC
H2O: soluble 1g/10 mL, clear, greenish-yellow
155.8 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Safety Information
NONH for all modes of transport
3
22-36/37/38
26-36-37/39
CV2295000
Xn
P301 + P312 + P330-P305 + P351 + P338
H302-H315-H319-H335
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 46 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)|A class of drugs that inhibit the activation of VOLTAGE-GATED SODIUM CHANNELS. (See all compounds classified as Voltage-Gated Sodium Channel Blockers.)
Amide, Procaine
Procainamide hydrochloride Use and Manufacturing
antiarrhythmic
Benzamide, 4-amino-N-[2-(diethylamino)ethyl]-, hydrochloride (1:1): ACTIVE
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:271.78
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:271.1451400
Monoisotopic Mass:271.1451400
Topological Polar Surface Area:58.4
Heavy Atom Count:18
Complexity:221
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
Drug Function and Efficacy
Unspecified
Registered Holders
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BIOPHORE INDIA PHARMACEUTICALS PVT LTD
Active
United States
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W R GRACE AND CO -CONN
Active
United States
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GLAND PHARMA LTD
Active
India
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