Wogonin
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Wogonin
structure -
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CAS No:
632-85-9
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Formula:
C16H12O5
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Chemical Name:
Wogonin
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Synonyms:
4H-1-Benzopyran-4-one,5,7-dihydroxy-8-methoxy-2-phenyl-;Flavone,5,7-dihydroxy-8-methoxy-;Wogonin;5,7-Dihydroxy-8-methoxy-2-phenyl-4H-1-benzopyran-4-one;5,7-Dihydroxy-8-methoxyflavone
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CAS No:
Description
Wogonin is a naturally occurring mono-flavonoid, can inhibit the activity of CDK8 and Wnt, and exhibits anti-inflammatory and anti-tumor effects.
Wogonin is a dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-8. It has a role as a cyclooxygenase 2 inhibitor, an antineoplastic agent, an angiogenesis inhibitor and a plant metabolite. It is a dihydroxyflavone and a monomethoxyflavone. It is a conjugate acid of a wogonin(1-).
Characteristics
76
3
yellow crystal
1.4±0.1 g/cm3
201 °C @ Solvent: Ethanol
518.8°C at 760 mmHg
198.4±23.6 °C
1.669
DMSO: ≥20mg/mL
2-8°C
Safety Information
III
8
3145
3
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . R36/37/38:Irritating to eyes, respiratory system and skin .
24/25
LK8331000
Drug Information
Wogonin has known human metabolites that include (2S,3S,4S,5R)-3,4,5-trihydroxy-6-(5-hydroxy-8-methoxy-4-oxo-2-phenylchromen-7-yl)oxyoxane-2-carboxylic acid.
5,7-dihydroxy-8-methoxyflavone
Wogonin Use and Manufacturing
Used for diuresis and lowering blood pressure.
Polyketides [PK] -> Flavonoids [PK12] -> Flavones and Flavonols [PK1211]
Computed Properties
Molecular Weight:284.26
XLogP3:3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:284.06847348
Monoisotopic Mass:284.06847348
Topological Polar Surface Area:76
Heavy Atom Count:21
Complexity:426
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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