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Morphine sulfate

Morphine sulfate structure

CAS No:
64-31-3
Formula:
C17H19NO3.¹/2H2O4S
Chemical Name:
Morphine sulfate
Synonyms:
Morphinan-3,6-diol,7,8-didehydro-4,5-epoxy-17-methyl- (5α,6α)-,sulfate (2:1);Morphinan-3,6α-diol,7,8-didehydro-4,5α-epoxy-17-methyl-,sulfate (2:1) (salt);Morphinan-3,6-diol,7,8-didehydro-4,5-epoxy-17-methyl- (5α,6α)-,sulfate (2:1) (salt);Morphine sulfate;Morphine sulphate;l-Morphine sulfate;NIH 10753;MST;Kapanol;Skenan;NIH 0001;Duramorph;Capros;Morphelan;Avinza;Oblioser;MST Continus;Moscontin;Relipain;Oramorph;Roxanol;NSC 11441;Infumorph;Dolcontin;Astramorph PF;SRM-rhotard;Kadian;MS-IR;Morphine sulfate immediate release tablet;P Guard;Arymo;1095-53-0;178935-96-1
Categories:
Analytical Chemistry > Standard

Description

The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.

Morphine sulfate Basic Attributes

Molecular Weight：

415.458

Exact Mass：

383.10400

EC Number：

200-582-8

DSSTox ID：

DTXSID4023830

Characteristics

PSA：

135.91000

XLogP3：

1.56400

Density：

1.32 at 20 deg C/4 deg C

Melting Point：

250 °C

Boiling Point：

476.2ºC at 760 mmHg

Flash Point：

11℃

Water Solubility：

Insoluble in diethyl ether, acetone; soluble in methanol, pyridine; slightly soluble in ethanol

Storage Conditions：

−20°C

Vapor Pressure：

1.8X10-10 mm Hg at 25 deg C (est)

Toxicity：

Oral-Rat LD50 461 mg/kg; Oral-Mouse LD50: 600 mg/kg

Flammability characteristics：

Combustible, fires emit nitrogen oxides, sulfur oxides pungently stimulate smoke

Safety Information

Transport codes：

UN 1230 3/PG 2

wgk germany：

hazard class code：

11-23/24/25-39/23/24/25

safety instructions：

7-16-36/37-45

Marks：

F,T

Storage features：

Treasury is ventilated at low temperature and dry; stored and transported separately from oxidants and food

Stability/Shelf Life：

When exposed to air, morphine sulfate gradually loses its water of hydration. The drug darkens on prolonged exposure to light.

Precautionary statement(s)：

P210-P260-P280-P301 + P310-P311

Hazard Statements：

H225-H301-H311-H331-H370

GHS Classification：

|Warning|H302 (93.33%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P264, P270, P281, P301+P312, P308+P313, P330, P405, and P501|Aggregated GHS information provided by 45 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH：

Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS. (See all compounds classified as Narcotics.)|Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS. (See all compounds classified as Analgesics, Opioid.)

MeSH Entry Terms：

Chloride, Morphine

Morphine sulfate Use and Manufacturing

Uses

Analgesic (narcotic).

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:383.4
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:8
Exact Mass:383.10387318
Monoisotopic Mass:383.10387318
Topological Polar Surface Area:136
Heavy Atom Count:26
Complexity:576
Defined Atom Stereocenter Count:5
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes