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Berberine hydrochloride

Berberine hydrochloride structure

CAS No:
633-65-8
Formula:
C20H18NO4.Cl
Chemical Name:
Berberine hydrochloride
Synonyms:
Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium,5,6-dihydro-9,10-dimethoxy-,chloride (1:1);Berbinium,7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)-,chloride;Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium,5,6-dihydro-9,10-dimethoxy-,chloride;Berberine,chloride;Berberine hydrochloride;Berberinium chloride;NSC 646666;NSC 163088;Berberine IR;16,17-Dimethoxy-5,7-dioxa-13λ5-azapentacyclo[11.8.0.0[2,10].0[4,8].0[15,20]]henicosa-1(21),2(10),3,8,13,15(20),16,18-octaen-13-ylium chloride;1082532-96-4
Categories:
Biochemical Engineering > Plant Extracts

Description

Berberine has shown to be effective in inhibiting cell proliferation and promoting apoptosis in various cancerous cells; MAPK and Wnt/β-catenin pathways affected by Berberine.IC50 value:Target: Anticancer agentThe plant-based alkaloid berberine has potential therapeutic applications for breast cancer, although a better understanding of the genes and cellular pathways regulated by this compound is needed to define the mechanism of its action in cancer treatment. In this review, the molecu

Berberine chloride (TN) is an organic molecular entity.|Berberine Chloride is the orally bioavailable, hydrochloride salt form of berberine, a quaternary ammonium salt of an isoquinoline alkaloid and active component of various Chinese herbs, with potential antineoplastic, radiosensitizing, anti-inflammatory, anti-lipidemic and antidiabetic activities. Although the mechanisms of action through which berberine exerts its effects are not yet fully elucidated, upon administration this agent appears to suppress the activation of various proteins and/or modulate the expression of a variety of genes involved in tumorigenesis and inflammation, including, but not limited to transcription factor nuclear factor-kappa B (NF-kB), myeloid cell leukemia 1 (Mcl-1), B-cell lymphoma 2 (Bcl-2), B-cell lymphoma-extra large (Bcl-xl), cyclooxygenase (COX)-2, tumor necrosis factor (TNF), interleukin (IL)-6, IL-12, inducible nitric oxide synthase (iNOS), intercellular adhesion molecule-1 (ICAM-1), E-selectin, monocyte chemoattractant protein-1 (MCP-1), C-X-C motif chemokine 2 (CXCL2), cyclin D1, activator protein (AP-1), hypoxia-inducible factor 1 (HIF-1), signal transducer and activator of transcription 3 (STAT3), peroxisome proliferator-activated receptor (PPAR), arylamine N-acetyltransferase (NAT), and DNA topoisomerase I and II. The modulation of gene expression may induce cell cycle arrest and apoptosis, and inhibit cancer cell proliferation. In addition, berberine modulates lipid and glucose metabolism.

Berberine hydrochloride Basic Attributes

Molecular Weight：

371.81400

Exact Mass：

371.09200

EC Number：

211-195-9

UNII：

UOT4O1BYV8

NSC Number：

757795|163088|646666

DSSTox ID：

DTXSID8024602

NCI Thesaurus Code：

C87331

HScode：

3003409000

Characteristics

PSA：

40.80000

XLogP3：

0.10030

Appearance：

yellow crystalline powder

Density：

1.654g/cm3

Melting Point：

214 °C

Water Solubility：

soluble in cold water

Storage Conditions：

Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from

Toxicity：

LD50 orl-rat: >15 g/kg KSRNAM 8,654,74

Collision Cross Section：

175.9 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

UN 1544

wgk germany：

hazard class code：

R20/21/22

safety instructions：

S24/25

RTECS Number：

DR9866400

Marks：

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P201, P202, P281, P308+P313, P405, P501

Hazard Statements：

H361

GHS Classification：

|Warning|H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]|P201, P202, P281, P308+P313, P405, and P501

Berberine hydrochloride Use and Manufacturing

Uses

An ingredient in some commercial eyewash products. It is effective in treating gastroenteritis, bacterial dysentery and other intestinal infections, conjunctivitis and suppurative otitis media. Recently, it has also been found that this product can block α-receptors and have anti-arrhythmic effects.

Manufacturing Info：

Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, 5,6-dihydro-9,10-dimethoxy-, chloride (1:1): ACTIVE

Use Classification：

Cosmetics -> Antimicrobial

Computed Properties

Molecular Weight:371.8
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:371.0924357
Monoisotopic Mass:371.0924357
Topological Polar Surface Area:40.8
Heavy Atom Count:26
Complexity:488
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Unspecified

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Berberine Hydrochloride
Manufacturer	Hainan Pharmaceutical FACTORY Co., Ltd.

Compound berberine tablets
Ingredients	Berberine hydrochloride, costusroot, evodia rutaecarpa, white peony root,
Indication	Not yet clear.
Specifications	Each tablet contains berberine hydrochloride 30mg
Manufacturer	Sichuan YIKE Pharmaceutical Co., Ltd.

Compound berberine tablets
Ingredients	Berberine hydrochloride, costusroot, evodia rutaecarpa, white peony root.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	Each tablet contains berberine hydrochloride 30mg
Manufacturer	Guilin Honghui Pharmaceutical Co., Ltd.

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Registered Holders

Yunnan Longfar Pharmaceutical Co., Ltd.

China
Active
Yunnan Datang Hanfang Pharmaceutical Co., Ltd.

China
Active
Sichuan Xieli Pharmaceutical Co., Ltd.

China
Active

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Guide of Berberine hydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Learn More Other Chemicals

Berberine hydrochloride

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