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Yohimbine hydrochloride

Yohimbine hydrochloride structure

CAS No:
65-19-0
Formula:
C21H26N2O3.ClH
Chemical Name:
Yohimbine hydrochloride
Synonyms:
Yohimban-16-carboxylic acid,17-hydroxy-,methyl ester,hydrochloride (1:1),(16α,17α)-;Yohimban-16α-carboxylic acid,17α-hydroxy-,methyl ester,monohydrochloride;Yohimban-16-carboxylic acid,17-hydroxy-,methyl ester,monohydrochloride,(16α,17α)-;Benz[g]indolo[2,3-a]quinolizine,yohimban-16-carboxylic acid deriv.;Yohimbine hydrochloride;Yohimbine monohydrochloride;Yohimbine chloride;NIH 9689;Antagonil;Actibine;Yohimex;Erex;Thybine;Yocon;Dayto-Himbin;Yohimbe;Aphrodyne;Yomax;NSC 19509;Yohimbex
Categories:
Active Pharmaceutical Ingredients > Nervous System Drugs

Description

Yohimbine hydrochloride is an alpha 2-adrenoreceptor antagonist, blocking the pre- and postsynaptic alpha-2 adrenoreceptors and causing an increased release of noradrenaline and dopamine.IC50 value:Target:In vitro:In vivo: Yohimbine hydrochloride (0.2 mg/kg, i.p.) was administered to rats 1h before the stress session daily for 14 consecutive days and its effect was assessed. Results of this section revealed that, immersion of rats in cold water significantly decreased sexual arousal and

A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of ERECTILE DYSFUNCTION.

Yohimbine hydrochloride Basic Attributes

Molecular Weight：

390.9

Exact Mass：

390.171021

EC Number：

200-600-4

UNII：

NB2E1YP49F

HScode：

2933990090

Characteristics

PSA：

65.6

XLogP3：

3.38700

Appearance：

white to off-white powder

Melting Point：

289 °C (decomp)

Boiling Point：

542.9°C at 760 mmHg

Flash Point：

282.184ºC

Refractive Index：

103 ° (C=1, H2O)

Water Solubility：

H2O: 10 mg/mL

Storage Conditions：

Refrigerator

Specific rotation：

99 º (c=1%, H2O, dry subst)

Collision Cross Section：

186 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Packing level：

Ⅱ

Hazard category：

6.1(a)

Transport codes：

UN 1544 6.1/PG 2

wgk germany：

hazard class code：

23/24/25-33-23/24

safety instructions：

22-36/37/39-45-24/25

RTECS Number：

ZG1015000

Marks：

Stability/Shelf Life：

Stable at room temperature in closed containers under normal storage and handling conditions. May decompose when exposed to light.

Precautionary statement(s)：

P261-P264-P280-P301 + P310-P311

Hazard Statements：

H300-H311-H331

GHS Classification：

|Danger|H300 (86.61%): Fatal if swallowed [Danger Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P311, P312, P321, P322, P330, P361, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 112 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Drugs that bind to and block the activation of ADRENERGIC ALPHA-2 RECEPTORS. (See all compounds classified as Adrenergic alpha-2 Receptor Antagonists.)|Agents that dilate the pupil. They may be either sympathomimetics or parasympatholytics. (See all compounds classified as Mydriatics.)|Drugs used in the treatment of urogenital conditions and diseases such as URINARY INCONTINENCE; PROSTATIC HYPERPLASIA; and ERECTILE DYSFUNCTION. (See all compounds classified as Urological Agents.)

MeSH Entry Terms：

Aphrodine Hydrochloride

Yohimbine hydrochloride Use and Manufacturing

Uses

Pharmacological probe for the study of a2-adrenoceptor.

Manufacturing Info：

Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, hydrochloride (1:1), (16.alpha.,17.alpha.)-: ACTIVE

Use Classification：

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Computed Properties

Molecular Weight:390.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:390.1710204
Monoisotopic Mass:390.1710204
Topological Polar Surface Area:65.6
Heavy Atom Count:27
Complexity:555
Defined Atom Stereocenter Count:5
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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Registered Holders

BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG

United States
Inactive
SIGMA F AND D DIV LTD

United States
Inactive
VITAL LABORATORIES PVT LTD

United States
Inactive

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