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2-Amino-4-methylpyridine

2-Amino-4-methylpyridine structure

CAS No:
695-34-1
Formula:
C6H8N2
Chemical Name:
2-Amino-4-methylpyridine
Synonyms:
2-Pyridinamine,4-methyl-;4-Picoline,2-amino-;4-Methyl-2-pyridinamine;W 45;RA 1226;2-Amino-4-methylpyridine;2-Amino-4-picoline;Ascensil;4-Methyl-2-pyridylamine;VMI 20-4;W 45 Raschig;4-Methyl-2-aminopyridine;2-Amino-γ-picoline;(4-Methylpyridin-2-yl)amine;Aminopicoline;NSC 1490;NSC 176165;NSC 6972;4-Methylpyridin-2-amine;135995-51-6
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

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Description

Light yellow to brown flakes

2-Amino-4-methylpyridine Basic Attributes

Molecular Weight：

108.14

Exact Mass：

108.14

BRN：

107066

EC Number：

234-190-3

UNII：

394N1Z644H

NSC Number：

6972|1490

DSSTox ID：

DTXSID1044720

HScode：

29333999

Characteristics

PSA：

38.9

XLogP3：

0.6

Appearance：

Slightly yellow to beige or brown Flakes

Density：

1.1±0.1 g/cm3

Melting Point：

100 °C

Boiling Point：

115-117 °C @ Press: 11 Torr

Flash Point：

118 °C

Refractive Index：

1.574

Water Solubility：

H2O: soluble ;DMF: freely soluble

Storage Conditions：

Refrigerator

Toxicity：

Oral-rat LD50: 200 mg/kg; Subcutaneous-mouse LD50: 64 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxide fumes

Safety Information

Packing level：

Hazard category：

6.1

Transport codes：

UN 3086 6.1/PG 1

wgk germany：

hazard class code：

45-46-60-61-8-21-25-26-34-42/43-48/23-50/53-36/37/38-33-23/24/25

safety instructions：

53-45-60-61-37/39-28A-26-36/37/39

RTECS Number：

TJ5150000

Marks：

Storage features：

Warehouse ventilated, low temperature and dry

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P261-P280-P301 + P310-P311

Hazard Statements：

H301 + H311 + H331-H373

GHS Classification：

|Danger|H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]|P260, P261, P264, P270, P271, P280, P301+P310, P302+P352, P304+P340, P305+P351+P338, P311, P312, P314, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 120 companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH Entry Terms：

2-amino-4-methylpyridine

2-Amino-4-methylpyridine Use and Manufacturing

Methods of Manufacturing

A mixture of 2-amino-3-chloro-4-methylpyridine 0.96 g (0. 0067πο1) and benzoic acid, 1.83 g (0.015 mol) was added, copper powder was added, reacted at 150 ° C for 1 h, and the reaction solution was added to water , Adding the decolorizer, adjusting the pH of the filtered solution to pH 9, filtering and drying the filter cake to obtain 0.65 g of crude 2-amino-4-methylpyridine as a yellow solid, the yield was 89.3percent. 2-amino-4-methylpyridine crude 0.65g dissolved in dilute hydrochloric acid solution to the crude product completely dissolved to obtain a salt solution, adding ethyl acetate to the salt solution to extract the water phase, slowly adding sodium bicarbonate to the aqueous phase Solution to pH 9, the solid was completely precipitated, filtered, and the filtrate was washed with distilled water and dried in vacuo to give 0.53 g of 2-amino-4-methylpyridine as a pale yellow solid with a yield of 81.5percent and a purity of 99.2percent 95-96. 6.38 (d, lH, J = 2.3 Hz); 6.34 (dd, lH, r, r = J = 5.7 Hz, 2.3 Hz); 3.46 (s, 2H); 2.39 (s, 3H);ESI-MS m / z (percent): 109.1 ([M + l] +)

Uses

Pharmaceutical intermediates.

Manufacturing Info：

2-Pyridinamine, 4-methyl-: ACTIVE

Computed Properties

Molecular Weight:108.14
XLogP3:0.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:108.068748264
Monoisotopic Mass:108.068748264
Topological Polar Surface Area:38.9
Heavy Atom Count:8
Complexity:72.9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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