Aceglatone
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Aceglatone
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CAS No:
642-83-1
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Formula:
C10H10O8
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Chemical Name:
Aceglatone
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Synonyms:
D-Glucaric acid,di-γ-lactone,2,5-diacetate;Glucaric acid,di-γ-lactone,diacetate,D-;Glucaric acid,1,4:6,3-dilactone,diacetate;Furo[3,2-b]furan,D-glucaric acid deriv.;2,5-di-O-Acetyl-D-glucosaccharo-(1→4:6→3)-dilactone;Glucaro-(1→4:6→3)-dilactone diacetate;Aceglatone;2,5-Di-O-acetyl-D-glucaro-(1→4:6→3)-dilactone;Glucaron;O2,O5-diacetylglucaric acid 1,4:6,3-dilactone;1195556-62-7
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CAS No:
Description
Aceglatone is an organic molecular entity.|Aceglatone is a derivative of D-glucaro-1, 4-lactone with chemopreventive and anti-tumor activities. One of the key processes in which human body eliminates toxic chemicals as well as hormones (such as estrogen) is by glucuronidation. When beta-glucuronidase deconjugates these glucuronides, it prolongs the stay of the hormone or toxic chemical in the body. Elevated beta-glucuronidase activity has been implicated to be associated with an increased risk for hormone-dependent cancers like breast, prostate, and colon cancers. Thereby, aceglatone may suppress the developments of hormone-dependent cancers mediated through beta-glucuronidase inhibition.
Computed Properties
Molecular Weight:258.18
XLogP3:-0.4
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:258.03756727
Monoisotopic Mass:258.03756727
Topological Polar Surface Area:105
Heavy Atom Count:18
Complexity:388
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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