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Aceglatone

Aceglatone structure

Aceglatone 

structure
  • CAS No:

    642-83-1

  • Formula:

    C10H10O8

  • Chemical Name:

    Aceglatone

  • Synonyms:

    D-Glucaric acid,di-γ-lactone,2,5-diacetate;Glucaric acid,di-γ-lactone,diacetate,D-;Glucaric acid,1,4:6,3-dilactone,diacetate;Furo[3,2-b]furan,D-glucaric acid deriv.;2,5-di-O-Acetyl-D-glucosaccharo-(1→4:6→3)-dilactone;Glucaro-(1→4:6→3)-dilactone diacetate;Aceglatone;2,5-Di-O-acetyl-D-glucaro-(1→4:6→3)-dilactone;Glucaron;O2,O5-diacetylglucaric acid 1,4:6,3-dilactone;1195556-62-7

  • Categories:

    Biochemical Engineering  >  Biological Response Modifiers

Description

Aceglatone is an organic molecular entity.|Aceglatone is a derivative of D-glucaro-1, 4-lactone with chemopreventive and anti-tumor activities. One of the key processes in which human body eliminates toxic chemicals as well as hormones (such as estrogen) is by glucuronidation. When beta-glucuronidase deconjugates these glucuronides, it prolongs the stay of the hormone or toxic chemical in the body. Elevated beta-glucuronidase activity has been implicated to be associated with an increased risk for hormone-dependent cancers like breast, prostate, and colon cancers. Thereby, aceglatone may suppress the developments of hormone-dependent cancers mediated through beta-glucuronidase inhibition.

Aceglatone Basic Attributes

258.18

258.18

347Q3OOJ13

DTXSID0048848

C984

2932999099

Characteristics

105

-0.4

1.49

191-192 °C

490ºC at 760 mmHg

224ºC

1.511

Drug Information

2,5-di-O-acetyl glucaro-(1,4)-(6-3)-dilactone

Computed Properties

Molecular Weight:258.18
XLogP3:-0.4
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:258.03756727
Monoisotopic Mass:258.03756727
Topological Polar Surface Area:105
Heavy Atom Count:18
Complexity:388
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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    CAS No.: 642-83-1
    Grade: Pharmaceutical Grade
    Content: 99%
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