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Sinomenine hydrochloride

Sinomenine hydrochloride structure

CAS No:
6080-33-7
Formula:
C19H23NO4.ClH
Chemical Name:
Sinomenine hydrochloride
Synonyms:
Morphinan-6-one,7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-,hydrochloride (1:1),(9α,13α,14α)-;9α,13α,14α-Morphinan-6-one,7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-,hydrochloride;Sinomenine hydrochloride;Morphinan-6-one,7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-,hydrochloride,(9α,13α,14α)-;Cucoline,hydrochloride;NSC 76021;Sinomenin hydrochloride;1089707-86-7
Categories:
Biochemical Engineering > Plant Extracts

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Description

Sinomenine hydrochloride is a blocker of the NF-κB activation and also an activator of μ-opioid receptor.

Sinomenine hydrochloride Basic Attributes

Molecular Weight：

365.85

Exact Mass：

365.139374

UNII：

2J34HRJ45S

NSC Number：

76021

HScode：

29334900

Characteristics

PSA：

59.00000

XLogP3：

2.75800

Appearance：

white to beige

Melting Point：

231 °C (decomp)

Boiling Point：

513.6ºC at 760 mmHg

Flash Point：

264.4ºC

Water Solubility：

H2O: soluble20mg/mL, clear

Storage Conditions：

2-8°C

Toxicity：

Subcutaneous-mouse LD50: 4.83 mg/kg

Flammability characteristics：

Combustible, the fire emits nitrogenous oxides and chlorides and spicy irritating smoke

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

24/25

RTECS Number：

QD2163000

Storage features：

Treasury is ventilated at low temperature and dry; stored and transported separately from oxidants and food

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P201, P202, P261, P264, P270, P271, P280, P281, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P308+P313, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH：

Drugs that are used to treat RHEUMATOID ARTHRITIS. (See all compounds classified as Antirheumatic Agents.)

MeSH Entry Terms：

4-hydroxy-3,7-dimethoxy-17-methylmorphin-7-en- 6-one

Sinomenine hydrochloride Use and Manufacturing

Sinomenine is an optical isomer of Methoxythebainone. Sinomenine was extracted from root of Sinomenium acutum. Sinomenine has anti-inflammatory and analgesic effect.

Computed Properties

Molecular Weight:365.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:365.1393859
Monoisotopic Mass:365.1393859
Topological Polar Surface Area:59
Heavy Atom Count:25
Complexity:562
Defined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It enhances the secretion of adrenal cortex hormone through the hypothalamus-pituitary-adrenal system, exerting a nonspecific anti-inflammatory effect; it has a significant inhibitory effect on egg white or formaldehyde-induced foot swelling in rats; it increases the pain threshold and has a significant analgesic effect; it is non-addictive.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Sinomenine Hydrochloride Enteric-coated Tablets
Ingredients	The main ingredient of this product is sinomenine hydrochloride.
Indication	When used in combination with histamine, the analgesic effect disappears.
Specifications	20mg
Manufacturer	Yantai Luyin Pharmaceutical Co., Ltd.

Zhengqing Fengtongning Tablets
Ingredients	Kunming Mountain Begonia.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	Each tablet contains 20 mg of sinomenine hydrochloride
Manufacturer	Hunan Warrant Pharmaceutical Co., Ltd.

Sinomenine Hydrochloride Enteric-coated Tablets
Ingredients	The main ingredient of this product is sinomenine hydrochloride.
Indication	When used in combination with histamine, the analgesic effect disappears.
Specifications	20mg
Manufacturer	Ankang Chia Tai Pharmacetucial Co., Ltd.

See More Related Drugs

Registered Holders

Hunan Zhengqing Pharmaceutical Co., Ltd.

China
Active
Beijing Tongrentang Technology Development Chengdu Co., Ltd.

China
Active

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Sinomenium Acutum extract Sinomenine Hydrochloride

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Guide of Sinomenine hydrochloride

Description
Basic Attributes
Characteristics
Safety Information
Toxicity
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Learn More Other Chemicals

Sinomenine hydrochloride

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