Quinacrine dihydrochloride dihydrate
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Quinacrine dihydrochloride dihydrate
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CAS No:
6151-30-0
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Formula:
C23H30ClN3O.2ClH.2H2O
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Chemical Name:
Quinacrine dihydrochloride dihydrate
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Synonyms:
1,4-Pentanediamine,N4-(6-chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-,hydrochloride,hydrate (1:2:2);Acridine,6-chloro-9-[[4-(diethylamino)-1-methylbutyl]amino]-2-methoxy-,dihydrochloride,dihydrate;1,4-Pentanediamine,N4-(6-chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-,dihydrochloride,dihydrate;Atabrine hydrochloride dihydrate;3-Chloro-7-methoxy-9-[[1-methyl-4-(diethylamino)butyl]amino]acridine dihydrochloride dihydrate;Mepacrine hydrochloride dihydrate;Quinacrine hydrochloride dihydrate;Quinacrine dihydrochloride dihydrate;133294-28-7
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CAS No:
Description
bright yellow powder
An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2.
Characteristics
55.85000
7.52080
bright yellow powder
247 °C
557.1ºC at 760 mmHg
H2O: 2.8 g/100 mL
Store below 40 deg C (104 deg F), preferably between 15 and 30 deg C (59 and 86 deg F) in a light-resistant container, unless otherwise specified by manufacturer. Store in a tight container.
1.8X10-10 mm Hg at 25 deg C (est)
Safety Information
22-36/37/38
26-37/39
Xn
Sensitive to light. /Quinacrine hydrochloride/
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 41 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Agents used to treat tapeworm infestations in man or animals. (See all compounds classified as Anticestodal Agents.)|Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585) (See all compounds classified as Antimalarials.)|Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice. (See all compounds classified as Antinematodal Agents.)|Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)|Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)
Acrichine
Computed Properties
Molecular Weight:508.9
Hydrogen Bond Donor Count:5
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:507.182225
Monoisotopic Mass:507.182225
Topological Polar Surface Area:39.4
Heavy Atom Count:32
Complexity:461
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:5
Compound Is Canonicalized:Yes
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Quinacrine dihydrochloride dihydrate
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