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Neomycin sulfate

Neomycin sulfate structure

CAS No:
1405-10-3
Formula:
H2O4S.xUnspecified
Chemical Name:
Neomycin sulfate
Synonyms:
Neomycin,sulfate (salt);Lidamycin Creme;Mycifradin N;Myciguent;Neo-Mantle Creme;Neomycin sulphate;Otobiotic;Quintess-N;Neomycin sulfate;Neolate;Neomix;Fradiomycin sulfate;Neofracin;Bykomycin;Mycerin sulfate;Mycifradin;New France F;Neobrettin;Endomixin;Neosulf;Nivemycin;Myacine;Biosol;Tuttomycin;Neo-rx;124847-89-8;125863-87-8;126663-40-9;126683-25-8;127085-47-6;1339-25-9;8013-33-0;8057-38-3;12710-33-7;37318-28-8;56571-68-7;57866-39-4;60799-77-1;63626-34-6
Categories:
Active Pharmaceutical Ingredients > Antibiotics

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Description

Neomycin sulfate is an aminoglycoside antibiotic used for preventing or treating bacterial infections.

Neomycin sulfate Basic Attributes

Molecular Weight：

712.72200

Exact Mass：

712.28000

EC Number：

223-969-3

NSC Number：

156885

DSSTox ID：

DTXSID4041074

HScode：

2941909000

Characteristics

PSA：

436.09000

XLogP3：

-4.26550

Appearance：

Tan powder.

Melting Point：

>187°C (dec.)

Boiling Point：

1046.1ºC at 760 mmHg

Flash Point：

586.5ºC

Refractive Index：

56 ° (C=10, H2O)

Water Solubility：

H2O: 50 mg/mL As a stock solution. Stock solutions should be filter sterilized and stored at 2-8°C. Stable at 37°C for 5 days.

Storage Conditions：

2-8ºC

Vapor Pressure：

0mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R42/43

safety instructions：

S23; S36/37; S45; S22; S36; S24/25

RTECS Number：

QP4375000

Marks：

Stability/Shelf Life：

Stable. Incompatible with strong oxidizing agents.

Precautionary statement(s)：

P261-P280-P342 + P311

Hazard Statements：

H317-H334

GHS Classification：

|Danger|H317 (99.15%): May cause an allergic skin reaction [Warning Sensitization, Skin]|P201, P202, P260, P261, P271, P272, P273, P280, P281, P285, P302+P352, P304+P340, P304+P341, P308+P313, P312, P314, P321, P333+P313, P342+P311, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 355 companies from 25 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Neomycin sulfate Use and Manufacturing

Uses

NEOMYCIN SULFATE is an aminoglycoside antibiotic produced by S. fradiae that inhibits protein translation by binding to the small subunit of prokaryotic ribosomes. It blocks voltage-sensitive Ca2+ channels and is a potent inhibitor of skeletal muscle sarcoplasmic reticulum Ca2+ release. NEOMYCIN SULFATE has been shown to inhibit inositol phospholipid turnover, phospholipase C, and phosphatidylcholine-phospholipase D activity (IC50 = 65 μM). It is highly effective against Gram-positive and Gram-negative bacteria and is commonly used for the prevention of bacterial contamination of cell cultures.

Manufacturing Info：

Neomycin, sulfate (salt): ACTIVE

Food Additive Classes：

Veterinary Drug -> ANTIMICROBIAL_AGENT;

Computed Properties

Molecular Weight:712.7
Hydrogen Bond Donor Count:15
Hydrogen Bond Acceptor Count:23
Rotatable Bond Count:9
Exact Mass:712.27966526
Monoisotopic Mass:712.27966526
Topological Polar Surface Area:436
Heavy Atom Count:47
Complexity:953
Undefined Atom Stereocenter Count:19
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Material

Sodium bisulfate monohydrate

Ammonium hydroxide

Ammonium sulfate

Price Analysis

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Drug Function and Efficacy

It has antibacterial effects on Staphylococcus (methicillin-sensitive strains), Corynebacterium, etc.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Qumixin Cream
Ingredients	This product is a compound preparation, and its components are 100 mg of miconazole nitrate, 10 mg of triamcinolone acetonide acetate, and 30,000 units of neomycin sulfate per 10 g.
Indication	If you are using other medicines, you should consult your physician or pharmacist before using this product.
Specifications	Compound

Streptomycin Sulfate Tablets
Ingredients	Molecular weight: C23H48N6O17S
Indication	1. Long-term use with oral contraceptives (containing estrogen) may lead to contraceptive failure and increase the incidence of bleeding. 2. Oral neomycin can affect the absorption of digitalis glycosides, fluorouracil, methotrexate, penicillin V, vitamin A or vitamin B12, reducing the efficacy; therefore, the patient's efficacy of digitalis drugs should be closely observed to see if there is a change. When patients taking oral neomycin take colchicine and vitamin A in combination, their vitamin B12 requirements may increase. 3. This product should not be used in combination with other nephrotoxic and ototoxic drugs. 4. When used in combination with neuromuscular blockers, it may increase the neuromuscular blocking effect and lead to skeletal muscle weakness, etc.
Specifications	0.1g (100,000 units)

Triamcinolone acetonide neomycin patch
Ingredients	This product is a compound preparation, each piece (patch) of which contains not less than 16μg of triamcinolone acetonide acetate and not less than 90 units of neomycin sulfate.
Indication	Not yet clear.
Specifications	6.5cm×4cm
Manufacturer	Guangzhou Baiyunshan Pharmaceutical Co.,ltd.baiyunshan Hejigong Pharmaceutical Factory

See More Related Drugs

Registered Holders

HUASHU PHARMACEUTICAL CORP

United States
Active
Zhejiang Fonow Medicine Co., Ltd.

China
Active
Yichang Sanxia Pharmaceutical Co., Ltd.

European Union
Active

See More Registered Holders

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