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Polymixin B sulfate

Polymixin B sulfate structure

CAS No:
1405-20-5
Formula:
H2O4S.xUnspecified
Chemical Name:
Polymixin B sulfate
Synonyms:
Polymyxin B,sulfate (salt);Polymyxin B,sulfate;Polymixin B sulfate;Aerosporin;Mastimyxin;Polymyxin B1-polymyxin B2 sulfate;124847-90-1;125753-33-5;55208-60-1;159561-05-4
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

White SolidPolymyxin (Aerosporin) was discovered in 1947 almost simultaneouslyin three separate laboratories in the UnitedStates and Great Britain. As often happens whensimilar discoveries are made in widely separated laboratories,differences in nomenclature, referring to both theantibiotic-producing organism and the antibiotic itself, appearedin references to the polymyxins. Because the organismsfirst designated as Bacillus polymyxa and B.aerosporus Greer were found to be identical species, th

Polymixin B sulfate Basic Attributes

Molecular Weight：

1301.56

Exact Mass：

1300.717307

EC Number：

215-774-7

HScode：

2941 90 00

Characteristics

PSA：

573.64000

XLogP3：

2.54990

Appearance：

colorless or slightly yellow powder

Melting Point：

217-220°C (dec.)

Boiling Point：

1651ºC at 760 mmHg

Flash Point：

952.3ºC

Water Solubility：

soluble in water at 50mg/ml/n

Storage Conditions：

2-8°C

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

3249

wgk germany：

hazard class code：

safety instructions：

22-24/25

RTECS Number：

TR1150000

Marks：

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

Polymixin B sulfate Use and Manufacturing

Antibiotic with bactericidal action on E. coli. Binds to the lipid A portion of bacterial lipopolysaccharides. Induces pore formation in the membranes of cortex cells from excised sorghum roots. Mixture of Polymyxin B1 and B2 sulfate.Biological potency (dry basis): >6000U/mg.

Drug Function and Efficacy

No specific pharmacological effects mentioned

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Polymyxin B sulfate

Compound neomycin polymyxin eye drops
Ingredients	Each milliliter contains: prednisolone acetate 5 mg, neomycin sulfate 5 mg (equivalent to 3.5 mg neomycin), polymyxin sulfate 10,000 units, liquid membrane component (polyvinyl alcohol) 14 mg, thimerosal 0.01 mg, Tween 80, propylene glycol, sodium acetate, and purified water.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	5ml

AEROSOOTHE- triple antibiotic ointment_ointment
Manufacturer	Aero Healthcare US LLC

Registered Holders

NORTH CHINA PHARMACEUTICAL HUASHENG CO LTD

United States
Active
XELLIA PHARMACEUTICALS ApS

Denmark
Active
Biotika a.s.

Slovakia
Active

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