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Gentamicin sulfate

Gentamicin sulfate structure

CAS No:
1405-41-0
Formula:
H2O4S.xUnspecified
Chemical Name:
Gentamicin sulfate
Synonyms:
Gentamicin,sulfate (salt);Gentamycin,sulfate (salt);Gentamycin sulfate;Gentamicin sulfate;Urocydin;Gentamicin sulphate;Geramycin;Genticyn;Gentalin;Garamycin;Refobacin L;Refobacin 10;Refobacin;Sulmycin;Gentacin;Gentocin;Septopal;Alcomicin;Gentak;Nichogencin;Bristagen;Gent-Ophtal;Gentibioptal;Garasol;Duragentam;Cidomycin;Gentamicin C complex sulfate;Genticin;Ophtagram;Gentrasul;Pangram;U-gencin;Genoptic;Gentogram;Lugacin;Gentalyn;Dispagent;Gentamina;Gentacidin;Garasent;Genta Swift;Intragen;Eltacin;11121-41-8;12687-65-9;50816-05-2;64438-35-3;126989-70-6;1629030-99-4
Categories:
Active Pharmaceutical Ingredients > Antibiotics

Description

Gentamicin sulfate, an aminoglycoside antibiotic, inhibits the growth of both gram-positive and gram-negative bacteria and to inhibit several strains of mycoplasma in tissue culture. It inhibits DNase I with an IC50 of 0.57 mM.

Gentamicin sulfate Basic Attributes

Molecular Weight：

1506.80000

Exact Mass：

1505.88000

HScode：

2941901000

Characteristics

PSA：

719.38000

XLogP3：

-1.26180

Appearance：

White to buff-colored powder. Odorless.

Melting Point：

218-237 °C

Boiling Point：

797.6ºC at 760 mmHg

Flash Point：

436.2ºC

Water Solubility：

H2O: 50 mg/mL As stock solution, store at −20°C. Stable at 37°C for 5 days.

Storage Conditions：

2-8ºC

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R42/43

safety instructions：

S23-S36/37-S45

RTECS Number：

LY2625000

Marks：

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P261-P280-P342 + P311

Hazard Statements：

H317-H334

Gentamicin sulfate Use and Manufacturing

Inhibits protein synthesis by binding to L6 protein of 50S ribosomal subunit. Antibacterial. Antibiotic complex consists of three closely related components, gentamicins C1, C2, C1a, and also gentamicin A which differs from the other members of the

Material

Magnesium sulfate heptahydrate

Ammonium chloride

Sodium hydroxide

Ammonium hydroxide

Calcium carbonate

Glucose

Hydrochloric acid

Ammonia

Sulfuric acid

Ferrous sulfate

Starch

Price Analysis

Make your Gentamicin sulfate purchase based on the price and market insights! ECHEMI provides professional market insights with prices for you to make a better choice. Learn more on Gentamicin sulfate prices .

Drug Function and Efficacy

Aminoglycoside antibiotics have good antibacterial effects on various Gram-negative and Gram-positive bacteria. The mechanism of action is to bind to the 30S subunit of bacterial ribosomes and inhibit the synthesis of bacterial proteins.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Gentamycin Sulfate Injection
Ingredients	The main ingredient of this product is gentamicin sulfate, which is a multi-component antibiotic containing components such as C1, C1a, C2a, and C2.
Indication	1. When used in combination with other aminoglycosides or when used topically or systemically successively, it may increase the possibility of producing ototoxicity, nephrotoxicity and neuromuscular blocking effects. 2. When used in combination with neuromuscular blockers, it may aggravate neuromuscular blocking effects, leading to symptoms such as muscle weakness and respiratory depression. 3. When used in combination with capreomycin, cisplatin, ethacrynic acid, furosemide or vancomycin (or norvancomycin), or when used topically or systemically successively, it may increase ototoxicity and nephrotoxicity. 4. When used topically or systemically with cephalothin or cefazolin, it may increase nephrotoxicity. 5. When used in combination with polymyxin injections or when used topically or systemically successively, it may increase nephrotoxicity and neuromuscular blocking effects. 6. Other nephrotoxic and ototoxic drugs should not be used in combination with this product or when used topically successively, so as not to aggravate nephrotoxicity or ototoxicity. 7. When aminoglycosides and beta-lactams (cephalosporins and penicillins) are mixed, they may lead to mutual inactivation. When this product is used in combination with the above-mentioned antibiotics, it must be dripped in separate bottles. This product should not be infused in the same bottle with other drugs.
Specifications	1ml: 40,000 units
Manufacturer	Guangdong Nanguo Pharmaceutical Co., Ltd.

Gentamycin Sulfate Tablets
Ingredients	The main ingredient of this product is gentamicin sulfate, which is a multi-component antibiotic containing components such as C1, C1a, C2a, and C2.
Indication	1. When used in combination with other aminoglycosides or when applied topically or systemically successively, it may increase the possibility of producing ototoxicity, nephrotoxicity and neuromuscular blocking effects. 2. When used in combination with neuromuscular blockers, it may aggravate neuromuscular blocking effects, leading to symptoms such as muscle weakness and respiratory depression. 3. When used in combination with capreomycin, cisplatin, ethacrynic acid, furosemide or vancomycin (or norvancomycin), or when applied topically or systemically successively, it may increase ototoxicity and nephrotoxicity. 4. When used topically or systemically with cephalothin or cefazolin, it may increase nephrotoxicity. 5. When used in combination with polymyxin injections or when applied topically or systemically successively, it may increase nephrotoxicity and neuromuscular blocking effects. 6. Other nephrotoxic and ototoxic drugs should not be used in combination with this product or applied topically successively, so as not to aggravate nephrotoxicity or ototoxicity.
Specifications	20 mg (20,000 units)

Gentamycin Sulfate Injection
Ingredients	The chemical name of gentamicin sulfate is N-(5-methoxy-2-pyrimidinyl)-4-aminobenzenesulfonamide.
Indication	1. When used in combination with other aminoglycosides or when applied topically or systemically successively, it may increase the possibility of producing ototoxicity, nephrotoxicity and neuromuscular blocking effects. 2. When used in combination with neuromuscular blockers, it may aggravate neuromuscular blocking effects, leading to symptoms such as muscle weakness and respiratory depression. 3. When used in combination with capreomycin, cisplatin, ethacrynic acid, furosemide or vancomycin (or norvancomycin), or when applied topically or systemically successively, it may increase ototoxicity and nephrotoxicity. 4. When used topically or systemically with cephalothin or cefazolin, it may increase nephrotoxicity. 5. When used in combination with polymyxin injections or when applied topically or systemically successively, it may increase nephrotoxicity and neuromuscular blocking effects. 6. Other nephrotoxic and ototoxic drugs should not be used in combination with this product or when applied topically successively, so as not to aggravate nephrotoxicity or ototoxicity. 7. When aminoglycosides and β-lactams (cephalosporins and penicillins) are mixed, they may lead to mutual inactivation. When this product is used in combination with the above antibiotics, it must be dripped in separate bottles. This product should not be dripped in the same bottle with other drugs.
Specifications	2ml: 40,000 units
Manufacturer	Sinopharm Ronshyn Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

ACS DOBFAR SPA

Italy
Active
Shanxi Zhongbao Pharmaceutical Co., Ltd.

China
Active
Shaanxi Xiyue Pharmaceutical (Fufeng) Co., Ltd.

China
Active

See More Registered Holders

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