β-Carboline
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β-Carboline
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CAS No:
244-63-3
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Formula:
C11H8N2
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Chemical Name:
β-Carboline
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Synonyms:
9H-Pyrido[3,4-b]indole;Carbazoline;β-Carboline;2,9-Diazafluorene;Norharman;Norharmane;2-Azacarbazole;NSC 84417
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CAS No:
Description
Norharmane (Norharman), isolated from coffee, is a potent and selective monoamine oxidase A (MAO-A) inhibitor with a Ki of 3.34 μM[1].
Solid
Beta-carboline is the parent compound of the beta-carbolines, a tricyclic structure comprising an indole ring system ortho- fused to C-3 and C-4 of a pyridine ring. It has a role as a marine metabolite and a fungal metabolite. It is a member of beta-carbolines and a mancude organic heterotricyclic parent.
Characteristics
28.7
3.2
light yellow crystalline
1.3±0.1 g/cm3
199 °C
391.3°C at 760 mmHg
182.1±11.7 °C
1.785
2693g/L(17 ºC)
2-8°C
5.62E-06mmHg at 25°C
dnd-hmn:hla 50 mmol/L MUREAV 89,95,81
132.2 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Drug Information
Toxic substances from microorganisms, plants or animals that interfere with the functions of the nervous system. Most venoms contain neurotoxic substances. Myotoxins are included in this concept. (See all compounds classified as Neurotoxins.)|Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes. (See all compounds classified as Mutagens.)
beta-carboline
Computed Properties
Molecular Weight:168.19
XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Exact Mass:168.068748264
Monoisotopic Mass:168.068748264
Topological Polar Surface Area:28.7
Heavy Atom Count:13
Complexity:193
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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