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(2-Hydroxyethyl)urea

(2-Hydroxyethyl)urea structure

CAS No:
2078-71-9
Formula:
C3H8N2O2
Chemical Name:
(2-Hydroxyethyl)urea
Synonyms:
Urea,N-(2-hydroxyethyl)-;Urea,(2-hydroxyethyl)-;N-(2-Hydroxyethyl)urea;Monoethylolurea;N-(β-Hydroxyethyl)urea;(2-Hydroxyethyl)urea;(β-Hydroxyethyl)urea;Monoethanolurea;1-(2-Hydroxyethyl)urea;NSC 1127;Hydrovance
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

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Description

Colorless to slightly yellow transparent liquid

(2-Hydroxyethyl)urea Basic Attributes

Molecular Weight：

104.11

Exact Mass：

104.11

EC Number：

215-304-0

UNII：

MBQ7DDQ7AR

NSC Number：

1127

DSSTox ID：

DTXSID4051663

HScode：

2924199090

Characteristics

PSA：

75.4

XLogP3：

-1.7

Density：

1.2±0.1 g/cm3

Melting Point：

94-95 °C

Boiling Point：

254.3°C at 760 mmHg

Flash Point：

107.6±25.1 °C

Refractive Index：

1.490

Water Solubility：

almost transparency

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R36/37/38

safety instructions：

S26-S36/37/39

RTECS Number：

YT4907000

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

(2-Hydroxyethyl)urea Use and Manufacturing

Methods of Manufacturing

Synthesis of 1-hydroxy-ethyl-6-aminouracil (compound 1) Metal sodium (2.8 g, 120 mmol) was added carefully in 90 mL of ethanol anhydride in a 200 mL mad apple-type flask with a stirrer coated with fluoropolymer in ice bath with constant stirring and was completely dissolved. Then, 6.3 g (60 mmol) of hydroxyethylurea and 6.4 mL (60 mmol) of ethylcyanoacetate were added and refluxed for seven hr. The obtained solution was filtrated, washed with ethanol, solubilized in water, neutralized with 1.0 M diluted hydrochloric acid, filtrated and provided white pellets, which were recrystallized in water and gave compound 1 as a white crystal (6.1 g, 35.6 mmol, yield: 59.4percent); 1H NMR (DMSO-d6, 400 MHz): delta 3.54 (t, 2H, NCH2CH2, 9.6 Hz), 3.83 (t, 2H, CH2OH, 9.6 Hz), 4.57 (br, 1H, CHCNH2), 5.09 (br, 1H, OH), 6.61 (br, 2H, NH2), 10.32 (br, 1H, NH); 13C NMR (DMSO-d6, 100 MHz): delta 44.13 (NaC2CH2), 59.28 (CH2OH), 76.52 (CHCNH2), 151.87, 157.04, 162.89.

Manufacturing Info：

Urea, N-(hydroxyethyl)-: ACTIVE

Computed Properties

Molecular Weight:104.11
XLogP3:-1.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:104.058577502
Monoisotopic Mass:104.058577502
Topological Polar Surface Area:75.4
Heavy Atom Count:7
Complexity:64
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Hydroxyethyl urea is a moisturizing agent that enhances skin hydration by increasing water retention in the stratum corneum.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

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