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N6-[(1,1-Dimethylethoxy)carbonyl]-N2-[(phenylmethoxy)carbonyl]-L-lysine

N6-[(1,1-Dimethylethoxy)carbonyl]-N2-[(phenylmethoxy)carbonyl]-L-lysine structure

CAS No:
2389-60-8
Formula:
C19H28N2O6
Chemical Name:
N6-[(1,1-Dimethylethoxy)carbonyl]-N2-[(phenylmethoxy)carbonyl]-L-lysine
Synonyms:
L-Lysine,N6-[(1,1-dimethylethoxy)carbonyl]-N2-[(phenylmethoxy)carbonyl]-;Lysine,N2,N6-dicarboxy-,N2-benzyl N6-tert-butyl ester,L-;N6-[(1,1-Dimethylethoxy)carbonyl]-N2-[(phenylmethoxy)carbonyl]-L-lysine;Nε-[(tert-Butoxy)carbonyl]-Nα--[(benzyloxy)carbonyl]-L-lysine;N2-Benzyloxycarbonyl-N6-tert-butoxycarbonyl-L-lysine;Z-Lys(Boc)-OH;Cbz-Lys(Boc)-OH;NSC 164047;(S)-2-(Benzyloxycarbonylamino)-6-(tert-butoxycarbonylamino)hexanoic acid;N-α-Benzyloxycarbonyl-N-ε-tert-butoxycarbonyl-L-lysine;Cbz-L-Lys(Boc)-OH;(2S)-6-[(2-Methylpropan-2-yl)oxycarbonylamino]-2-(phenylmethoxycarbonylamino)hexanoic acid;53665-57-9
Categories:
Biochemical Engineering > Amino Acids and Derivatives

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Description

White crystals

N6-[(1,1-Dimethylethoxy)carbonyl]-N2-[(phenylmethoxy)carbonyl]-L-lysine Basic Attributes

Molecular Weight：

380.44

Exact Mass：

380.44

EC Number：

219-223-1

NSC Number：

164047

HScode：

2924299090

Characteristics

PSA：

114

XLogP3：

2.8

Appearance：

White Powder.

Density：

1.1±0.1 g/cm3

Melting Point：

63-70°C

Boiling Point：

587ºC at 760 mmHg

Flash Point：

203.5±27.3 °C

Refractive Index：

1.485

Water Solubility：

soluble in DMF (0.5 mmol/ml).

Storage Conditions：

2-8°C

Vapor Pressure：

1.26E-14mmHg at 25°C

N6-[(1,1-Dimethylethoxy)carbonyl]-N2-[(phenylmethoxy)carbonyl]-L-lysine Use and Manufacturing

N-α-Cbz-(S)-Lysine (5g, 17.85mmol) was dissolved in a mixture of THF (5OmL) and water (5OmL). To this sodium bicarbonate (3g, 35.5mmol, 2eq) and a solution OfBoCa. Synthesis of Compound 1 (NBoc-Cbz Lysine) N-?-Cbz-(S)-Lysine (5 g, 17.85 mmol) was dissolved in a mixture of THF (50 mL) and water (50 mL). To this sodium bicarbonate (3 g, 35.5 mmol, 2 eq) and a solution of Boc2O (9 g, 41 mmol, 2.3 eq) in THF (50 mL). After stirring at room temperature overnight, the THF was removed under reduced pressure and the resulting aqueous solution was neutralized with 2N HCl. This was extracted with ethyl acetate and the combined organic layers were washed with brine. The organic layer was dried with sodium sulfate and concentrated to a clear oil. Removal of excess Boc2O by Kugelrhor distillation resulted in a thick clear oil weighing 6.8 g, 100percent. 1H NMR (CDCl3) ' 11.6 (s, 1H), 7.32 (s, 5H), 6.36 (s, 1H), 5.75 (d, 1H, J=8), 5.09 (s, 2H), 4.37 (m, 1H), 3.06 (m, 2H), 1.78 (m, 2H), 1.53 (s, 4H), 1.42 (s, 9H). 13C NMR (CDCl3) ' 174.8, 155.4, 135.4, 127.6, 127.3, 127.2, 78.6, 66.1, 52.9, 39.2, 31.0, 28.6, 27.5, 26.6, 21.4Example 6. Synthesis of Lysine Teroxazole Intermediate 309; A lysine teroxazole intermediate that can be used to prepare compounds of the invention can be prepared as follows

Computed Properties

Molecular Weight:380.4
XLogP3:2.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:12
Exact Mass:380.19473662
Monoisotopic Mass:380.19473662
Topological Polar Surface Area:114
Heavy Atom Count:27
Complexity:483
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of N6-[(1,1-Dimethylethoxy)carbonyl]-N2-[(phenylmethoxy)carbonyl]-L-lysine

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

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Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

N-Cbz-N-Boc-L-lysine

CAS No.: 2389-60-8

Content: 99.00%

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Compound Net Biotechnology Inc. Contact Supplier

CN
2 YRS

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Manufactory Supplier of 4-(Pentafluorothio)aniline,Pentafluoro,Pentafluorothio,Pentafluorosulfur,[4-(bromomethyl)phenyl]-pentafluoro-lambda6-sulfane,[4-(pentafluoro-sulfanyl)phenyl]acetic acid

2389-60-8 (2S)-6-[(2-methylpropan-2-yl)oxycarbonylamino]-2-(phenylmethoxycarbonylamino)hexanoic acid

CAS No.: 2389-60-8

Grade: Industrial Grade

Content: 95%

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Guide of N6-[(1,1-Dimethylethoxy)carbonyl]-N2-[(phenylmethoxy)carbonyl]-L-lysine

Description
Basic Attributes
Characteristics
Use and Manufacturing
Computed Properties
Recommended Suppliers
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N6-[(1,1-Dimethylethoxy)carbonyl]-N2-[(phenylmethoxy)carbonyl]-L-lysine

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