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Arecoline hydrobromide

Arecoline hydrobromide structure

CAS No:
300-08-3
Formula:
C8H13NO2.BrH
Chemical Name:
Arecoline hydrobromide
Synonyms:
3-Pyridinecarboxylic acid,1,2,5,6-tetrahydro-1-methyl-,methyl ester,hydrobromide (1:1);Nicotinic acid,1,2,5,6-tetrahydro-1-methyl-,methyl ester,hydrobromide;3-Pyridinecarboxylic acid,1,2,5,6-tetrahydro-1-methyl-,methyl ester,hydrobromide;Arecoline bromide;Arecoline hydrobromide;Methyl 1,2,5,6-tetrahydro-1-methylnicotinate hydrobromide;Methyl N-methyl-1,2,5,6-tetrahydronicotinate hydrobromide;Taeniolin
Categories:
Active Pharmaceutical Ingredients > Antiparasitic Drugs

Description

Arecoline Hydrobromide is a muscarinic acetylcholine receptor agonist. Target: mAChRArecoline is an alkaloid found in the areca nut. Arecoline. a drug obtained from the Areca Catechu L., induced a dose-dependent antinociception (0.3-1 mg kg(-1) i.p.) which was prevented by the muscarinic antagonists pirenzepine (0.1 microg per mouse i.c.v.) and S-(-)-ET-126 (0.01 microg per mouse i.c.v.) [1]. Arecoline exerts its excitatory actions by binding to M2-muscarinic receptors on the cell membra

Arecoline hydrobromide Basic Attributes

Molecular Weight：

236.11

Exact Mass：

235.020782

EC Number：

206-087-3

UNII：

24S79B9CX7

NSC Number：

757418|31750

DSSTox ID：

DTXSID9075379

HScode：

29399990

Characteristics

PSA：

29.5

XLogP3：

1.31730

Appearance：

White to light yellow Powder

Melting Point：

169-171 °C

Boiling Point：

209°C at 760 mmHg

Flash Point：

81.1ºC

Water Solubility：

H2O: 0.1 g/mL, clear, colorless

Storage Conditions：

Refrigerator

Toxicity：

Subcutaneous-mouse LDL0: 65 mg/kg; intravenous-mouse LD50: 18 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxides and hydrogen bromide fumes

Safety Information

Hazard category：

6.1

Transport codes：

1544

wgk germany：

hazard class code：

22-23/24/25

safety instructions：

45-38-36/37/39-28A

RTECS Number：

QT2275000

Marks：

Xn,T

Storage features：

Treasury is ventilated, low temperature and dry; stored separately from food materials

Precautionary statement(s)：

P301 + P312 + P330

Hazard Statements：

H302

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH Entry Terms：

arecoline hydrobromide

Arecoline hydrobromide Use and Manufacturing

A cholinergic alkaloid from seeds of the betel nut palm Areca catechu. Anthelmintic (Cestodes); cathartic.

Computed Properties

Molecular Weight:236.11
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:235.02079
Monoisotopic Mass:235.02079
Topological Polar Surface Area:29.5
Heavy Atom Count:12
Complexity:187
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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